中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (34): 6351-6354.doi: 10.3969/j.issn.1673-8225.2011.34.020

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

短碳纤维增强聚醚醚酮为全髋假体材料的生物相容性及力学性能

王克军，郭卫春，唐  谨，余  铃，赵胜豪   

  1. 武汉大学人民医院骨1科，湖北省武汉市  430060
  • 收稿日期:2011-05-11 修回日期:2011-07-11 出版日期:2011-08-20 发布日期:2011-08-20
  • 通讯作者: 郭卫春，副教授，武汉大学人民医院骨1科，湖北省武汉市 430060 guoweichun@hotmail.com
  • 作者简介:王克军★，男，1970年生，湖北省荆州市人，汉族，武汉大学医学部在读硕士，主要从事生物工程研究。 575841165@qq.com
  • 基金资助:

    武汉大学研究生基金资助项目。

Short carbon fiber reinforced polyetgeretherketone for hip prosthesis: Biocompatibility and biomechanics

Wang Ke-jun, Guo Wei-chun, Tang Jin, Yu Ling, Zhao Sheng-hao   

  1. Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan  430060, Hubei Province, China
  • Received:2011-05-11 Revised:2011-07-11 Online:2011-08-20 Published:2011-08-20
  • Contact: Guo Wei-chun, Associate professor, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China guoweichun@hotmail.com
  • About author:Wang Ke-jun★, Studying for master’s degree, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China 575841165@qq.com
  • Supported by:

     the Postgraduate Fund of Wuhan University*

PDF

485

被引次数

17

摘要：

背景：聚醚酮类聚合物具有良好的生物相容性，但在玻璃化转变温度后其模量、力学强度下降严重，不能为骨骼生长提供一个稳定的环境。
目的：评价短碳纤维增强聚醚醚酮作为全髋假体材料的生物相容性及生物力学性能。
方法：以MTT法、溶血试验、急性全身毒性试验、热原试验评价短碳纤维增强聚醚醚酮浸提液的体外生物相容性；将短碳纤维增强聚醚醚酮接骨板植入兔体内，观察骨板周围包膜形成情况和一般组织情况；对短碳纤维增强聚醚醚酮试件行应力测试。
结果与结论：短碳纤维增强聚醚醚酮材料的细胞相对存活率大于75%，溶血率小于5%，说明其血液相容性较好；植入兔肌肉内未引起明显炎症反应，早期有少量淋巴细胞聚集，植入体为纤维组织包裹，随着时间的延长，淋巴细胞逐渐减少直至消失，纤维包膜逐渐稳定，周围肌肉组织始终保持正常结构，表明短碳纤维增强聚醚醚酮材料无任何毒性，组织相容性好。应力测试显示短碳纤维增强聚醚醚酮材料符合人体髋关节的生物力学强度需要。

关键词: 短碳纤维, 聚醚醚酮, 髋关节, 应力测试, 生物相容性, 生物材料

Abstract:

BACKGROUND: Polyetgeretherketone has good biocompatibility, but its modulus and mechanical strength characteristics drop badly upon glass-transition temperature, so as to fail to provide a steady condition for bone growth.  
OBJECTIVE: To observe the biocompatibility and biomechanics of short carbon fiber reinforced polyetgeretherketone as hip prosthesis by animal experiment.
METHODS: The biocompatibility in vitro was measured by MTT, hemolysis test, acute toxicity experiment and pyrogen experiment; SCF/PEEK composite plates were implanted into the rabbits, and the formation of fibrous capsules and general tissues conditions around the plates were observed under the optical microscope; The stress tests were carried on the WE-SA universal testing machine.
RESULTS AND CONCLUSION: The relative survival rate was > 75%, the hemolysis rate < 5%, indicating a good blood compatibility. There was no evident difference between the two groups. As the time goes on, the relation between the implanted-plates and capsules was more and more close, and inflammatory cells became gradually less.

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