中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (16): 2905-2910.doi: 10.3969/j.issn.1673-8225.2011.16.013

• 组织工程口腔材料 tissue-engineered oral materials • 上一篇    下一篇

β-磷酸三钙支架材料即刻植入对保存剩余牙槽嵴的影响

胡  杨1，马  莹2，何惠宇1   

  1. 1新疆医科大学第一附属医院口腔修复科，新疆维吾尔自治区乌鲁木齐市 830054
    2广州市天河区中心医院口腔科，广东省广州市  510630
  • 收稿日期:2010-10-25 修回日期:2010-12-19 出版日期:2011-04-16 发布日期:2013-11-11
  • 通讯作者: 何惠宇，博士，教授，主任医师，新疆医科大学第一附属医院口腔修复科，新疆维吾尔自治区乌鲁木齐市 830054 hehuiyu2@sina.com
  • 作者简介:胡杨★，男，1983年生，湖北省黄冈市人，汉族，2009年新疆医科大学毕业，硕士，医师，主要从事组织工程与口腔种植修复技术研究。 joe98344@sina.cn joe98344@126.com 第二作者：马莹，女，1983年生，新疆维吾尔自治区乌鲁木齐市人，回族，2009年新疆医科大学毕业，硕士，医师，主要从事组织工程与口腔种植修复技术研究。 mayingiris@163.com
  • 基金资助:

    新疆维吾尔自治区科技攻关项目(200533118)，课题名称：组织工程骨用于即刻牙种植骨结合的实验研究；新疆维吾尔自治区高校科研计划科学研究重点项目(xj EDU2009I22)，课题名称:bFGF基因转染的骨髓间充质干细胞复合异种煅烧骨修复颌骨缺损的实验研究。

Effect of immediate implantation of beta-tricalcium phosphate scaffold on preserving the alveolar ridge

Hu Yang1, Ma Ying2, He Hui-yu1   

  1. 1Department of Prosthodontics, First Affiliated Hospital, Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China
    2Department of Stomatology, Tianhe Central Hospital of Guangzhou, Guangzhou  510630, Guangdong Province, China
  • Received:2010-10-25 Revised:2010-12-19 Online:2011-04-16 Published:2013-11-11
  • Contact: He Hui-yu, Doctor, Professor, Chief physician, Department of Prosthodontics, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China hehuiyu2@sina.com
  • About author:Hu Yang★, Master, Physician, Department of Prosthodontics, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China joe98344@sina.cn Ma Ying, Master, Physician, Department of Stomatology, Tianhe Central Hospital of Guangzhou, Guangzhou 510630, Guangdong Province, China mayingiris@163.com
  • Supported by:

    the Science and Technology Project of Xinjiang Uygur Autonomous Region, No. 200533118*; the Key Project of Scientific Research for Scientific Research Planning of Higher Education of Xinjiang Uygur Autonomous Region, No. xjEDU2009I22*

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摘要：

背景：拔牙后在牙槽窝内即刻植入成骨材料，如脱蛋白小牛骨、羟基磷灰石、硬组织代用品、人脱钙冻干骨等，可防止或延缓牙槽嵴在拔牙后的快速、持续吸收。
目的：观察β-磷酸三钙支架材料即刻植入对剩余牙槽嵴保存的影响。
方法：完整拔除18只新西兰大白兔双侧下颌中切牙，一侧牙槽窝内即刻植入β-磷酸三钙作为实验组，另一侧不处理作为对照组。术后4，8，12周测量剩余牙槽嵴长度、宽度、高度；甲苯胺蓝染色观察术区牙槽嵴愈合过程中的组织病理改变，X射线观察术区牙槽嵴骨密度改变，扫描电镜观测β-磷酸三钙与拔牙窝骨小梁的结合界面。
结果与结论：术后8，12周时，实验组牙槽嵴高度、宽度及长度均高于对照组(P < 0.05)。随着时间的延长，实验组拔牙窝内可见成骨细胞散在分布，新生骨小梁逐渐增多，血管网由稀疏变得丰富，新生骨与β-磷酸三钙结合日益紧密，并且β-磷酸三钙不断降解，与拔牙窝牙槽骨交界处有新生骨组织形成。说明β-磷酸三钙具有良好的骨传导特性及生物相容性，拔牙后即刻植入β-磷酸三钙材料可有效保存剩余牙槽嵴解剖形态，防止牙槽嵴的进一步吸收。

关键词: 剩余牙槽嵴, &beta, -磷酸三钙, 即刻植入, 拔牙, 口腔生物材料

Abstract:

BACKGROUND: The bone materials were immediately implanted into dental alveoli after tooth extraction, such as deproteinized small cattle bone, hydroxyapatite and hard tissue substitutes, human demineralized freeze-dried bone, etc. These materials could prevent or delay the rapid, sustained absorption of alveolar ridge after tooth extraction.
OBJECTIVE: To observe the effect of immediate implantation of β-tricalcium phosphate (β-TCP) on preserving the residual alveolar.
METHODS: The bilateral and mandibular central incisors of 18 New Zealand White rabbits were extracted, and β-TCP was implanted immediately into dental alveoli on one side as the experimental group, while the other side without implantion as control group. The length, width, and height of residual ridge was measured at 4, 8, 12 weeks after operation. The histopathological changes of the healing procedure of alveolar crest in the surgical region were observed by toluidine blue staining. Changes of bone mineral density of alveolar crest in the surgical region were observed by X-ray. The interface between β-TCP and trabecular bone of teeth extraction were observed by scanning electron microscopy.
RESULTS AND CONCLUSION: The height, width, and length of alveolar ridge in experimental group were higher than that in control group (P < 0.05) at 8, 12 weeks after operation. With the prolonged time, osteoblasts can be seen scattered in the experimental group, new trabecular bone was gradually increased and vascular network became more and more intensive. New bone and β-TCP combined with increasingly close, and β-TCP continued degradation, new bone tissue was formed in the interface between β-TCP and the alveolar bone. It suggested that β-TCP has good bone conduction properties and biological compatibility. It was implanted immediately after tooth extraction, which could effectively preserve the anatomic form of residual alveolar ridge, and prevent further absorption of alveolar ridge.

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