中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (14): 2629-2632.doi: 10.3969/j.issn.1673-8225.2011.14.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

肿瘤干细胞的研究进展

侯  萍，李剑平   

  1. 辽宁省血液中心输血医学研究所，辽宁省沈阳市  110044
  • 收稿日期:2010-11-17 修回日期:2011-01-20 出版日期:2011-04-02 发布日期:2013-11-02
  • 通讯作者: 李剑平，主任医师，辽宁省血液中心输血医学研究所，辽宁省沈阳市 110044 ljp_63@yahoo.com
  • 作者简介:侯萍★，女，1977年生，辽宁省沈阳市人，汉族，2005年中国医科大学毕业，硕士，主治医师，主要从事干细胞的研究。 houping77@163.com

Research progress in tumor stem cells

Hou Ping, Li Jian-ping   

  1. Institute of Transfusion Medicine, Liaoning Blood Center, Shenyang  110044, Liaoning Province, China
  • Received:2010-11-17 Revised:2011-01-20 Online:2011-04-02 Published:2013-11-02
  • Contact: Li Jian-ping, Chief physician, Institute of Transfusion Medicine, Liaoning Blood Center, Shenyang 110044, Liaoning Province, China ljp_63@yahoo.com
  • About author:Hou Ping★, Master, Attending physician, Institute of Transfusion Medicine, Liaoning Blood Center, Shenyang 110044, Liaoning Province, China houping77@163.com

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摘要：

背景：肿瘤干细胞具有高度增殖和分化能力，但又不同于普通干细胞，此类干细胞还具有发展成为肿瘤的特性，因此备受学者们关注。
目的：综述近几年来肿瘤干细胞的特性以及与干细胞和肿瘤的关系及其临床意义。
方法：应用计算机检索2000-01/2010-11 PubMed数据库、中国期刊全文数据库、万方数据库相关肿瘤干细胞的文章，中文检索词为“肿瘤干细胞”，英文检索词为“tumor stem cell”。共检索到文献89篇，最终纳入符合标准的30篇文献。
结果与结论：目前国内肿瘤干细胞还处于基础研究阶段，国外肿瘤干细胞在实验研究方面已经取得了一定的进展，而且也在临床应用研究方面有一定的突破。普遍认为肿瘤组织中存在肿瘤干细胞，肿瘤干细胞对肿瘤的发生发展和肿瘤治疗都有重要的作用，对肿瘤干细胞治疗肿瘤的临床应用前景也非常乐观，但肿瘤干细胞特征以及与成体干细胞关系仍处于初步研究阶段。

关键词: 肿瘤干细胞, 干细胞, 肿瘤, 临床, 综述文献

Abstract:

BACKGROUND: Tumor stem cells have a strong proliferation and differentiation, but different from normal stem cells.These stem cells also has developed into tumor, so they are widely concerned by scholars.
OBJECTIVE: To review the characteristic of tumor stem cells and the relationship with stem cells and tumor, and clinical significance.
METHODS: A computer-based online search of PubMed database, CNKI database, Wanfang database for articles of tumor stem cells was performed with the key words of “tumor stem cell” in Chinese and English, respectively. A total of 89 literatures were retrieved, and 30 documents of which were included.
RESULTS AND CONCLUSION: At present, tumor stem cell is still in the stage of basic research in China, while tumor stem cell has made some progress on experimental research and clinical application at abroad. It generally believed that tumor stem cells are existed in tumor tissue. Tumor stem cells play an important role in development and treatment of tumor, tumor stem cells for the treatment of tumor are also very optimistic about the prospects of clinical application, but the characteristics of tumor stem cells and relation with adult stem cells are still in the preliminary research stage.

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