中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (12): 2146-2148.doi: 10.3969/j.issn.1673-8225.2011.12.014

• 药物控释材料 drug delivery materials • 上一篇    下一篇

应用生物可降解材料玉米醇溶蛋白制备胃肠道生物黏附控释片

谢俊俊1，吴鸿飞1，鲁传华1，张群卫1，鲁  涛2   

  1. 1安徽中医学院药学院，安徽省现代中药研究与开发重点实验室，安徽省合肥市230038
    2安徽医科大学药学院，安徽省合肥市 230031
  • 收稿日期:2010-09-12 修回日期:2010-10-20 出版日期:2011-03-19 发布日期:2011-03-19
  • 通讯作者: 鲁传华，教授，安徽中医学院药学院，安徽省现代中药研究与开发重点实验室，安徽省合肥市 230038 lch@ahtcm.edu.cn
  • 作者简介:谢俊俊★，1979年生，江西省九江市人，汉族，安徽中医学院药学院在读硕士，药师，主要从事制剂新工艺研究。 sylt214@139.com
  • 基金资助:

    国家自然基金资助项目(81001703)。

Preparation of gastrointestinal bioadhesive controlled release tablets using biodegradable Zein

Xie Jun-jun1, Wu Hong-fei1, Lu Chuan-hua1, Zhang Qun-wei1, Lu Tao2   

  1. 1Anhui Province Key Laboratory for R&D of Chinese Medicine, College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei   230038, Anhui Province, China
    2College of Pharmacy, Anhui Medical University, Hefei   230038, Anhui Province, China
  • Received:2010-09-12 Revised:2010-10-20 Online:2011-03-19 Published:2011-03-19
  • Contact: Lu Chuan-hua, Professor, Anhui Province Key Laboratory for R&D of Chinese Medicine, College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China lch@ahtcm.edu.cn
  • About author:Xie Jun-jun★, Studying for master’s degree, Anhui Province Key Laboratory for R&D of Chinese Medicine, College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China sylt214@139.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81001703*

PDF

404

被引次数

3

摘要：

背景：胃肠道生物黏附控释制剂能延长药物制剂在胃肠道的停留时间，提高药物的生物利用度。
目的：制备5-氟尿嘧啶胃肠道生物黏附控释片。
方法：利用生物可降解性玉米醇溶蛋白为骨架材料和黏附材料，氟尿嘧啶为模型药，制备氟尿嘧啶胃肠道黏附控释片。对片芯工艺进行正交设计，优化包衣液的选择，观察生物黏附缓释片的体外黏附力及体内外相关性。
结果与结论：5-氟尿嘧啶玉米醇溶蛋白生物黏附片体外释放10 h内均符合零级释放特征，片剂具有较好的体外黏附力，且在2~8 h 内体内血药浓度较为平稳，没有明显峰谷现象，体内外释放吸收具有良好的相关性。

关键词: 玉米醇溶蛋白, 生物可降解材料, 生物黏附, 控释片, 体内外相关性

Abstract:

BACKGROUND: Gastrointestinal bioadhesive controlled release tablets can extend the residence time of pharmaceutical preparations in gastrointestinal tract, and increase drug bioavailability.
OBJECTIVE: To prepare 5-fluorouracil gastrointestinal bioadhesive controlled release tablets.
METHODS: Taking biodegradable Zein as stent material and adhesive material, fluorouracil as model drug, the gastrointestinal controlled release tablets were prepared. The chip technology was orthogonally designed to optimize the choice of coating solution, the in vitro bioadhesion of controlled release tablets and the correlation of in vivo and in vitro were also been studied.
RESULTS AND CONCLUSION: The fluorouracil Zein bioadhesive tablets were in line with zero-grade release characteristic in vitro within 10 hours. The prepared gastrointestinal bioadhesive controlled release tablets have good adhesive properties. Moreover, the blood drug concentration in vivo within 2-8 hours was relatively stable, without obvious peak valley, and there was a good correlation of the release and absorption in vivo and in vitro.

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