中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (8): 1381-1384.doi: 10.3969/j.issn.1673-8225.2011.08.012

• 药物控释材料 drug delivery materials • 上一篇    下一篇

盐酸替利定在Amberlite IRP-69上的静态离子交换特性

丁始安，李  楠，邓  岚，魏  佳，邓盛齐   

  1. 四川抗菌素工业研究所，四川省成都市610000
  • 收稿日期:2010-08-16 修回日期:2010-10-19 出版日期:2011-02-19 发布日期:2011-02-19
  • 通讯作者: 李楠，四川抗菌素工业研究所，四川省成都市 610000
  • 作者简介:丁始安★，女，1984年生，山东省青岛市人，汉族，2010年四川抗菌素工业研究所毕业，硕士，主要从事药物分析研究。 wanruq@qq.com

Static ion exchange characteristics of tilidine hydrochloride onto Amberlite IRP-69

Ding Shi-an, Li Nan, Deng Lan, Wei Jia, Deng Sheng-qi   

  1. Sichuan Industrial Institute of Antibiotics, Chengdu   610000, Sichuan Province, China
  • Received:2010-08-16 Revised:2010-10-19 Online:2011-02-19 Published:2011-02-19
  • Contact: Li Nan, Sichuan Industrial Institute of Antibiotics, Chengdu 610000, Sichuan Province, China
  • About author:Ding Shi-an★, Master, Sichuan Industrial Institute of Antibiotics, Chengdu 610000,Sichuan Province, China wanruq@qq.com

PDF

789

被引次数

6

摘要：

背景：离子交换树脂分子结构中含有可电离活化的基团，可以与离子性药物交换，使得药物进入其骨架而掩盖不良嗅味。
目的：观察盐酸替利定在Amberlite IRP-69上的离子交换平衡特性、热力学及动力学特征。
方法：采用静态离子交换法制备盐酸替利定树脂复合物，并进行离子交换平衡特性及动力学特征检测。
结果与结论：在293，303，313K 3个温度下及研究的浓度范围内，离子交换吸附等温方程、Freundlich方程和Langmuir方程都能够对盐酸替利定在Amberlite IRP-69上的离子交换行为进行很好的拟合。在290，298K下，其离子交换动力学特征基本符合一级动力学方程。盐酸替利定在Amberlite IRP-69上的离子交换热力学参数ΔH>0及ΔS > 0，表明该离子交换反应为吸热反应，温度升高有利于反应正向进行，且该反应是熵增加的反应；离子交换自由能变ΔG < 0，说明该离子交换反应能够自发进行。初始质量浓度为5 g/L的盐酸替利定在Amberlite IRP-69上的平衡交换吸附量为751.88 g/L。提示在室温下，可利用一定浓度的盐酸替利定溶液，加入一定量的Amberlite IRP-69作为载体，持续搅拌2 h制备药物树脂复合物，进而研制相关制剂。

关键词: 药物树脂, 离子交换特性, 盐酸替利定, Amberlite IRP-69, 生物材料与药物控释

Abstract:

BACKGROUND: Molecular structure of ion exchange resin contains activated groups which can be ionized, it can react with ionic drugs so that the bad smell of drugs is covered up.
OBJECTIVE: To study the ion exchange equilibrium characteristics, kinetics and thermodynamics of tilidine hydrochloride onto Amberlite IRP-69.
METHODS: The tilidine-resin complex was prepared by batch ion exchange method. The ion exchange equilibrium characteristics and kinetics were determined.
RESULTS AND CONCLUSION: Within the temperature range of 293, 303, 313 K, the exchange-adsorption isothermal equation, the Freundlich equation and the Langmuir equation could give perfect fitting for the ion exchange behavior of tilidine hydrochloride onto Amberlite IRP-69, the kinetics of ion exchange is a first-order kinetic equation. Thermodynamic parameters of ion-exchange of tilidine hydrochloride onto Amberlite IRP-69 (ΔH > 0, ΔS > 0) indicated that the ion exchange is endothermic, the temperature rise is beneficial for reaction, and entropy increases; free energy change (ΔG < 0) indicated that the reaction is spontaneous. The equilibrium exchange-adsorption of initial concentration of 5 g/L tilidine hydrochloride on Amberlite IRP-69 was 751.88 g/L. The drug-resin complex can be prepared at room temperature, by continuous stirring 2 hours using certain concentration of tilidine hydrochloride and certain amount of Amberlite IRP-69 as the carrier, and then to develop related products.

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