中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9399-.doi: 10.3969/j.issn.1673-8225.2010.50.022

• 组织构建与中医药 • 上一篇    下一篇

雌激素受体调节剂联合游泳运动干预去卵巢大鼠骨生化指标的变化

彭筱   

  1. 西昌学院体育学院，四川省西昌市  615022
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 作者简介:彭筱★，女， 1982年生， 四川省会理县人，汉族，2009年成都体育学院毕业，硕士，讲师，主要从事健身运动生理学方面的研究。 aoxiang1023@163.com

Changes in biomechanical indexes of ovariectomized rats interfered by selective estrogen receptor modulator and swimming exercise

Peng Xiao   

  1. Physical Education College, Xichang College, Xichang  615022, Sichuan Province, China
  • Online:2010-12-10 Published:2010-12-10
  • About author:Peng Xiao★, Master, Lecturer, Physical Education College, Xichang College, Xichang 615022, Sichuan Province, China aoxiang1023@163.com

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摘要：

背景：研究发现运动和雌激素联合作用对去卵巢大鼠松质骨骨量的丢失有预防作用，但有关运动与选择性雌激素受体调节剂联合作用对骨代谢的影响方面的研究较少。

目的：通过对去卵巢大鼠血液生化指标的比较，探讨游泳运动与选择性雌激素受体调节剂联合作用对去卵巢大鼠骨代谢的影响。

方法：将50只雌性SD大鼠随机分为5组：假手术组仅手术不切除卵巢，其余各组去卵巢造模，运动组、药物组及运动+药物组分别在去卵巢的基础上进行游泳训练和(或)灌胃选择性雌激素受体调节剂雷洛昔芬。8周后，比较各组大鼠血液生化指标的变化。

结果与结论：卵巢摘除的早期对大鼠进行运动干预可抑制大鼠体质量的快速增加。与模型组比较，运动组、药物组、运动+药物组大鼠血磷及碱性磷酸酶水平明显升高(P < 0.05或P < 0.01)，血清抗酒石酸酸性磷酸酶水平显著降低(P < 0.05)，均以运动+药物组效果最明显，但各组间血钙水平差异无显著性意义(P > 0.05)。说明游泳运动和(或)选择性雌激素受体调节剂均可在一定程度上改善骨代谢的血液生化指标，延缓骨丢失，抑制高转换型骨代谢率，以选择性雌激素受体调节剂和运动联合作用效果最佳。

关键词: 绝经后骨质疏松, 游泳, 选择性雌激素受体调节剂, 骨生化指标, 骨组织工程

Abstract:

BACKGROUND: Studies demonstrated that the combination of sports and estrogen play a prevention effects on bone loss of ovariectomized rats, however, there are few reports concerning the effects of sports and selective estrogen receptor modulators (SERMs) on bone metabolism.
OBJECTIVE: To investigate the combined efforts of swimming and SERMs on bone metabolism of ovariectomized rats by comparing biomechanical index.
METHODS: Totally 50 female SD rats were randomly divided into 5 groups. All rats were made ovariectomized models except that in the sham-surgery group. Swimming exercise and (or) SERMs raloxifene were performed on rats in the exercise, medicine, and exercise + medicine groups. The changes of blood biochemical index were compared among groups at 8 weeks after operation. 
RESULTS AND CONCLUSION: Exercise intervention at the early stage of ovariotomy could inhibit the rapid weight increase. Compared with model group, the serum phosphorus and alkaline phosphatase levels in the exercise, medicine, and exercise + medicine groups were obviously increased (P < 0.05 or P < 0.01), tartrate-resistant acid phosphatase levels were dramatically decreased (P < 0.05), especially in the exercise + medicine group, but the difference had no significant (P > 0.05). The results demonstrated that, swimming exercise and (or) SERMs can improve blood biochemical index in bone metabolism, delay bone loss, and inhibit high conversion rate of bone metabolism. The combination of these two interventions exhibit optimal effects.

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