中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (42): 7903-7906.doi: 10.3969/j.issn.1673-8225.2010.42.027

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

药物缓释涂层支架的材料学特点及其生物相容性

曾伟杰1，支峭原2   

  1. 1解放军第四二一医院心血管内科，广东省广州市     510318；2华南理工大学法学院，广东省广州市     510006
  • 出版日期:2010-10-15 发布日期:2010-10-15
  • 作者简介:曾伟杰★，女，1963年生，广东省广州市人，汉族，1994年华东师范大学毕业，硕士，主任护师，主要从事心血管内科和医学心理学的研究。 zengweijie2002@yahoo.com.cn

Material science characteristics and biocompatibility of drug-eluting stents

Zeng Wei-jie1, Zhi Qiao-yuan2   

  1. 1 Department of Cardiology, The 421 Hospital of Chinese PLA, Guangzhou   510318, Guangdong Province, China; 2 School of Law, South China University of Technology, Guangzhou   510006, Guangdong Province, China
  • Online:2010-10-15 Published:2010-10-15
  • About author:Zeng Wei-jie★, Master, Chief nurse, Department of Cardiology, The 421 Hospital of Chinese PLA, Guangzhou 510318, Guangdong Province, China zengweijie2002@yahoo.com.cn

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421

被引次数

9

摘要：

目的：阐述药物涂层支架的材料学特点，分析其生物相容性。
方法：检索PubMed数据库和中国期刊全文数据库有关药物缓释涂层支架材料学特点及生物相容性的文献，以“心血管，药物缓释，雷帕霉素，紫杉醇，冠状动脉，生物相容性，支架材料”为检索词，对资料进行初审，并查看文献后的引文文献。排除重复研究或Meta分析类文章。
结果： ①心血管支架中药物涂层支架材料的改进更新均以改善生物相容性和生物力学性能为目标。②心血管支架的生物相容性是一个复杂的连锁过程，血液相容性和组织相容性是评定生物相容性的两项基本内容。③利用有限元分析心血管支架材料的力学特性可为未来支架的优化设计提供有益的帮助。
结论：药物涂层支架的研究涉及药物学、生物学、材料学多学科交叉，研究药物缓释载体的控释机制，寻找血液相容性更好的药物缓释载体，加强缓释载体与机体的结合强度是当前支架药物缓释载体研究所要解决的问题。

关键词: 药物缓释涂层, 心血管支架, 生物力学, 生物相容性, 有限元分析

Abstract:

OBJECTIVE: To describe the materials science of drug eluting stents, and to analyzes its biocompatibility.
METHODS: A computer research of PubMed database and China Academic Journal Full-text database was performed for articles about materials science and biocompatibility of drug eluting stents, using “cardiovascular, drug delivery, rapamycin, paclitaxel, coronary artery, biocompatibility, stents” as the Chinese key words. The literatures were primarily checked, and the citations of each literature were looked over. Duplicated study or Meta analysis was excluded.
RESULTS:  ① The drug-eluting cardiovascular stents are updated with aim to improve the biocompatibility and biomechanical properties. ② Cardiovascular stents biocompatibility is a complex chain process, blood compatibility and tissue compatibility are two basic elements for the assessment of the biocompatibility. ③ Analysis of mechanical properties of cardiovascular stents using finite element analysis provides helpful reference for the optimal design of future stent.
CONCLUSION: The study involved drug-eluting stents is an interdisciplinary crossing of pharmacology, biology and materials science, it is the key problems urgent to be solved in study of controlled release drug delivery system that to investigate the mechanism underlying drug controlled-release carrier, to find drug controlled-release carriers with better blood compatibility, and to enhance bonding strength between controlled-release carriers and the body.

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