中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (42): 7883-7886.doi: 10.3969/j.issn.1673-8225.2010.42.022

• 生物材料综述 biomaterial review • 上一篇    下一篇

纳米羟基磷灰石/明胶/聚乙烯醇生物复合材料的界面结合及机械强度

王  峰1，宋恩民2，郭恩言1，赵  萍1，来启辉1   

  1. 1 玻璃与陶瓷材料山东省重点实验室，山东轻工业学院，山东省济南市  250353;2 煤炭工业济南设计研究院有限公司，山东省济南市  250031
  • 出版日期:2010-10-15 发布日期:2010-10-15
  • 作者简介:王峰☆，女，1970年生，山东省济南市人，汉族，2005年山东大学毕业，博士，副教授，主要从事纳米材料和生物医用材料的研究。 Wf890916@163.com
  • 基金资助:

    山东省自然科学资金(Y2007F33)，课题名称“聚乙烯醇/明胶/羟基磷灰石人工载荷骨复合材料的交联机理及其性能”。

Interface binding and mechanical strength of nano-hydroxyapatite/gelatin/polyvinyl-alcohol biocomposites

Wang Feng1, Song En-min2, Guo En-yan1, Zhao Ping1, Lai Qi-hui1   

  1. 1 Shandong Key Laboratory of Glass and Ceramics, Shandong Institute of Light Industry, Jinan   250353, Shandong Province, China; 2 Coal Industry Jinan Design and Research Co., Ltd., Jinan   250031, Shandong Province, China
  • Online:2010-10-15 Published:2010-10-15
  • About author:Wang Feng☆, Doctor, Associate professor, Shandong Key Laboratory of Glass and Ceramics, Shandong Institute of Light Industry, Jinan 250353, Shandong Province, China Wf890916@163.com
  • Supported by:

    Natural Science Foundation of Shandong Province, No. Y2007F33*

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摘要：

背景：纳米羟基磷灰石的化学组成接近生物体骨质的无机成分，具有良好的生物活性及生物相容性，可以用来修复损坏或者病变的硬组织，在整形外科及口腔修复方面得到了广泛的应用。但由于脆性大，限制了其在载荷骨替代方面的应用。近几年，纳米羟基磷灰石/有机物复合材料的研究受到了广泛关注。
目的：对纳米羟基磷灰石/明胶/聚乙烯醇生物复合材料的研究进行综述。
方法：应用计算机检索Science Direct 数据库和CNKI数据库(1994-01/2009-12)，以“纳米羟基磷灰石；明胶；聚乙烯醇；复合材料”或“nano-HA; Gel; PVA; Composite”为检索词进行检索。共检索126篇相关文献，排除发表时间过早，重复及类似研究，纳入24篇符合标准的文献。
结果与结论：分析羟基磷灰石/明胶/聚乙烯醇复合材料中三相之间的相互作用，发现聚乙烯醇可以起到交联剂的作用。使纳米羟基磷灰石/明胶/聚乙烯醇复合材料中形成大量化学键，导致复合材料中产生复杂的网状结构，增强了纳米羟基磷灰石、明胶、聚乙烯醇三相之间的界面结合，提高了复合材料的机械强度。因此，聚乙烯醇有望逐渐替代目前研究较多的醛类交联剂，避免醛类交联剂对羟基磷灰石/明胶复合材料的毒性污染。

关键词: 纳米羟基磷灰石, 明胶, 聚乙烯醇, 复合材料, 文献综述

Abstract:

BACKGROUND: Chemical composition of nano-hydroxyapatite is close to the bone inorganic ingredients, has a good biological activity and biocompatibility, and can be used to repair damage hard tissue or lesions, has been widely used in plastic surgery and oral restoration. Its wide application as load-bearing implants is limited due to its brittleness. In recent years, nano- hydroxyapatite/organics composites have been widely investigated.
OBJECTIVE: To review studies on nano-hydroxyapatite/gelatin/polyvinyl-alcohol composites.
METHODS: Databases of Science Direct and CNKI were retrieved between January 1994 and December 2009 using key words of “nano-hydroxyapatite; gel; PVA; composite” in English and in Chinese. Totally 126 related articles were selected. Earlier published, duplicated and similar studies were excluded, 24 articles were summarized.
RESULTS AND CONCLUSION: Interaction between three phases in nano-hydroxyapatite/gelatin/polyvinyl-alcohol composites showed polyvinyl-alcohol acts as a crosslink reagent. Due to increasing formation of chemical bonds and complex network structure in three phases, the interface binding and mechanical properties of nano-hydroxyapatite/gelatin/polyvinyl-alcohol composites were improved. Therefore, polyvinyl-alcohol would be a potential crosslink reagent, avoiding the pollution of aldehyde crosslink reagents.

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