中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (20): 3797-3800.doi: 10.3969/j.issn.1673-8225.2010.20.043

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    

组织工程化静脉瓣的研究现状与发展趋势

袁建明，党瑞山，沈曼茹，张传森   

  1. 解放军第二军医大学生物医学工程研究所，上海市 200043
  • 出版日期:2010-05-14 发布日期:2010-05-14
  • 通讯作者: 张传森，教授 解放军第二军医大学生物医学工程研究所，上海市 200043
  • 作者简介:袁建明，男，1976年生，江西省九江市人，汉族，2008年解放军第二军医大学在读博士，主管检验师，主要从事组织工程化静脉瓣的在体研究。
  • 基金资助:

    国家自然科学基金资助项目(30672045)
    上海市自然科学重点基金项目(08441900600)。

Current research and development of tissue engineered venous valve

Yuan Jian-ming, Dang Rui-shan, Shen Man-ru, Zhang Chuan-sen   

  1. Institute of Biomedical Engineering, Second Military Medical University of Chinese PLA, Shanghai   200043, China
  • Online:2010-05-14 Published:2010-05-14
  • Contact: Zhang Chuan-sen, Professor, Institute of Biomedical Engineering, Second Military Medical University of Chinese PLA, Shanghai 200043, China chuansen@yahoo.com
  • About author:Yuan Jian-ming, Studying for doctoral degree, Laboratorian in charge, Institute of Biomedical Engineering, Second Military Medical University of Chinese PLA, Shanghai 200043, China yjmdragon@ yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30672045*;
    Natural Science Key Projects of Shanghai, No. 08441900600*

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被引次数

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摘要：

目的：综述国内外组织工程静脉瓣的研究现状，分析组织工程化静脉瓣在临床应用的发展趋势。
方法：应用计算机检索2000-01/ 2009-08 PubMed、ProQuest Health& Medical Complete数据库、Springer英文期刊全文数据库、Elsevier全文数据库相关文章，检索词为“tissue engineering venous valve”，并限定文章语言种类为English。同时计算机检索2000-01/2009-08重庆维普科技期刊数据库、清华同方学术期刊数据库、中国生物医学文献数据库相关文章，检索词为“组织工程静脉瓣”，并限定文章语言种类为中文。此外还手工查阅相关专著数部。
结果：综合分析，可归纳总结出一种比较理想的组织工程化静脉瓣构建方法是将内皮祖细胞和多能成体祖细胞联合应用，分批种植在同种异体来源的脱细胞静脉支架上，在三维立体培养系统上不断加压灌注，最大程度模拟体内环境，使种子细胞能很好的在支架材料上生长成有功能的组织工程化静脉瓣。为组织工程化静脉瓣的临床应用提供实验基础。
结论：目前组织工程化静脉瓣的研究取得了相当大的进展和令人鼓舞的成绩，为深静脉功能不全患者带来了曙光，在深静脉功能不全治疗领域有广泛的应用前景。

关键词: 组织工程静脉瓣, 种子细胞, 支架材料, 生物反应器

Abstract:

OBJECTIVE: To review the current research of tissue engineered venous valve at home and abroad, to analyze the developing trend of tissue engineered venous valve in the clinical application.
METHODS: A computer retrieve was performed among PubMed, ProQuest Health & Medical Complete database, Springer English Academic Journal Full-text database, Elsevier Full-text database between January 2000 and August 2009, with the key words of “tissue engineering venous valve”, and the language was limited to English. At the same time, Chongqing VIP database, Qinghua Academic Journals Database, Chinese Biomedical Literature database were also screened on computer by using the key words “tissue engineered venous valve”, and the language was limited to Chinese. In addition, the relevant monographs were manually checked.
RESULTS: The comprehensive analysis shows that an ideal method to construct tissue engineered venous valve is to combine progenitor cells with multipotent adult progenitor cells for the batched incubation in allogenic acellular vein scaffolds, in vivo environment can be maximally simulated through constant pressure perfusions on the three-dimensional culture system, thus seed cells can well grow into functional tissue engineered venous valve on the scaffold materials. This study provides experimental basis for clinical application of venous valve tissue engineering.
CONCLUSION: At present, tissue engineered venous valve research has made considerable progress and encouraging results, brings first lights for deep venous insufficiency for patients, and exhibits wide application in the field of deep venous insufficiency treatment.

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