中国组织工程研究

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四川省成年健康人1 989名脉压差及相关因素调查

徐东江1，斯 琴1，祖淑玉1，徐  涛2，韩少梅2，徐成丽1，朱广瑾1   

  1. 中国医学科学院基础医学研究所，北京协和医学院基础学院，1生理学与病理生理学系，2流行病-统计学系，北京市100005
  • 出版日期:2010-03-12 发布日期:2010-03-12
  • 通讯作者: 朱广瑾，教授，博士生导师，中国医学科学院基础医学研究所北京协和医学院基础学院生理学与病理生理学系，北京市 100005 zhugj@pumc.edu.cn
  • 作者简介:徐东江，男，1984年生，山东省日照市人，汉族，中国医学科学院基础医学研究所，北京协和医学院基础学院在读硕士，主要从事心血管病理生理学研究和人体生理常数调查研究。
  • 基金资助:

    国家科技部基础性专项重大课题(2006FY300110)。

Investigation of pulse pressure and related factors of 1 989 healthy adults in Sichuan province

Xu Dong-jiang1, Si Qin1, Zu Shu-yu1, Xu Tao2, Han Shao-mei2, Xu Cheng-li1, Zhu Guang-jin1   

  1. 1Department of Physiology and Pathophysiology, 2Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College , Beijing  100005, China
  • Online:2010-03-12 Published:2010-03-12
  • Contact: Zhu Guang-jin, Professor, Doctoral supervisor, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
  • About author:Xu Dong-jiang, Studying for mater’s degree, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
  • Supported by:

    the Key Program of Science and Technology Basic Special Foundation of Ministry of Science and Technology, No. 2006FY300110*

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摘要：

背景：调查研究发现，无论高血压人群还是正常血压人群，脉压差增大都是动脉硬化和心血管疾病危险度增大的标志之一。
目的：通过对四川省1 989名成年健康人群脉压差及其相关因素分析，探讨预防脉压差过大、降低心血管疾病发病率以及提高人群生活质量等问题。
方法：采取分层、整群抽样，对1 989名健康成年人进行问卷调查，并进行体质检查和血液生物化学血糖、肾功能以及血脂4项等检测，分析脉压差与各观察指标间的关系。
结果与结论：男性、女性脉压差随年龄增加而增加，其中50岁以上人群，脉压差随年龄呈线性增加，空腹血糖、尿酸、血尿素氮、总胆固醇、三酰甘油、收缩压、舒张压随脉压差增大而增大，且年龄、BMI、腰臀比、三酰甘油与脉压差呈线性依存关系，脉压差与体育锻炼呈显著负相关。脉压差随着年龄、BMI、腰臀比、三酰甘油增加而增加，随着脉压差的增大，肾功能和血糖调节能力相对下降。提示，中老年人群需要通过合理饮食、运动控制向心性肥胖，从而控制脉压差，减小脉压差增大对肾脏功能损害，降低心血管疾病发病率。

关键词: 脉压差, 腰臀比, 血脂, 肾功能, 成年人, 健康人

Abstract:

BACKGROUND: High pulse pressure is the signal of arteriosclerosis or cardiovascular diseases for both hypertension and normal blood pressure population.
OBJECTIVE: The pulse pressure and related factors of healthy adults in Sichuan province were analyzed to explore the method for preventing excessive pulse pressure and improving the quality of life.
METHODS: Hierarchical, cluster sampling were performed in 1 989 healthy adults. The physical examination, blood glucose, renal function and blood fat were detected, and the relation of pulse pressure and its related factors were analyzed.
RESULTS AND CONCLUSION: Pulse pressure increased following the age, especially showed a linear increasing in those who more than 50-year-old. The increased pulse pressure leaded to larger fasting plasma glucose, uric acid, blood urea nitrogen, total cholesterol, triacylglycerol, systolic pressure and diastolic pressure, in addition, the age, body mass index, waist-to-hip ratio, triacylglycerol and pulse pressure showed a linear relationship. But physical exercise was negative correlated to pulse pressure. With pulse pressure increasing, the renal function and regulating capacity of blood glucose was decreased. The results suggested that mid-aged population should take reasonable diet and more physical exercise to prevent central obesity and excessive pulse pressure, reduce the risk of renal dysfunction and the incidence of cardiovascular disease.

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