中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (11): 2022-2025.doi: 10.3969/j.issn.1673-8225.2010.11.031

• 组织构建综述 tissue construction review • 上一篇    下一篇

过氧化物酶体增殖物受体γ共激活因子1与骨骼肌的适应性机制

邓 雷1，王 松2，牛 洁2   

  1. 1江苏经贸职业技术学院体育系，江苏省南京市 211168；
    2解放军理工大学理学院军事系，江苏省南京市  211101
  • 出版日期:2010-03-12 发布日期:2010-03-12
  • 作者简介:邓 雷，男，1963年生，江苏省南京市人，汉族，1986年扬州师范学院体育系毕业，副教授，主要从事体育保健方面的研究。dd588@vip.sina.com

Peroxisome proliferator-activated receptor-gamma coactivator 1 and skeletal muscle adaptation

Deng Lei1, Wang Song2, Niu Jie2   

  1. 1Department of Physical Education, Jiangsu Institute of Economic and Trade Technology, Nanjing   211168, Jiangsu Province, China;
    2Department of Military Education and Training, Basic College of the PLA University of Science and Technology, Nanjing   211101, Jiangsu Province, China
  • Online:2010-03-12 Published:2010-03-12
  • About author:Deng Lei, Associate professor, Department of Physical Education, Jiangsu Institute of Economic and Trade Technology, Nanjing 211168, Jiangsu Province, China dd588@vip.sina.com

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摘要：

背景：肌肉收缩活性的增加可诱导多种信号分子转录，并通过专有的信号通路激活细胞核内大量基因的表达。
目的：综述过氧化物酶体增殖物受体γ共激活因子1与骨骼肌的适应机制相关方面的研究。
方法：以PGC1，skeletal muscle，exercise，adaptations为检索词，检索Pubmed数据库(1995/2009-01)。文献检索语种限制为英文。纳入PGC1与运动性骨骼肌适应的相关内容。排除重复性研究。以PGC1与线粒体的氧化代谢，以及运动诱导PGC1s变化与骨骼肌适应为评价指标。
结果与结论：计算机初检得到57篇文献，根据纳入排除标准，对34篇进行分析。长期的耐力训练可诱导骨骼肌发生可塑性变化，包括线粒体的生物合成、肌纤维类型的改变和毛细血管密度的增加。转录因子高度依赖共激活分子从转录水平调控这些运动诱导生理性适应过程。这些转录因子的目标基因大部分涉及到线粒体的生物合成和细胞的新陈代谢，其转录调控方式可能为了解运动性能量变化特征的信号通路与线粒体生物合成及其功能之间的关系提供基本框架。提示过氧化物酶体增殖物受体γ共激活因子1α蛋白自身转录后，存在多种蛋白修饰，与多种生物学过程密切相关，可能在运动诱导骨骼肌的适应机制方面起着重要作用。

关键词: 肌肉肥大, 运动, 生理性适应, 共激活剂, 综述文献

Abstract:

BACKGROUND: An increase in activity of muscle contraction can induce transcription of a variety of signaling molecules to activate a large number of gene expression within the nucleus through proprietary signaling pathway.
OBJECTIVE: To review studies related the peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) and exercise induced skeletal muscle adaptations.
METHODS: A computer-based online search of Pubmed was performed for relevant English articles published from January 1995 to January 2009 with the keywords of “PGC1, skeletal muscle, exercise, adaptations”. The relevant articles about PGC-1 and exercise induced skeletal muscle adaptations were included, and repetitive contents were excluded. PGC1 and mitochondrial oxidative metabolism, and exercise-induced skeletal muscle adaptation and PGC1s changed served as the evaluation indicators.
RESULTS AND CONCLUSION: Of 57 collected articles, 34 were classified and sorted according to the criteria. Endurance training results in profound adaptations for skeletal muscle, including mitochondrial biogenesis, capillary density, and fiber composition. Transcription factors are highly dependent on coactivator molecules to regulate training physiologic adaptation processes. The majority of transcription factors target genes are involved in mitochondrial biogenesis and metabolism. These transcriptional patterns may provide a basic framework for understanding the integration of mitochondrial biogenesis and function with signaling events that exercise induced energetic properties. Post-transcription of PGC-1 alpha protein, there are a variety of protein modifications, with a variety of biological processes closely related to the possible adaptive mechanism of exercise-induced skeletal muscle.

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