中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (10): 1861-1864.doi: 10.3969/j.issn.1673-8225.2010.10.032

• 干细胞综述 • 上一篇    下一篇

肿瘤干细胞与肿瘤血管生成研究进展

张华锋，盛玉文，姜华茂   

  1. 辽宁医学院第一附属医院泌尿外科，辽宁省锦州市 121000
  • 出版日期:2010-03-05 发布日期:2010-03-05
  • 通讯作者: 盛玉文，教授，辽宁医学院第一附属医院泌尿外科，辽宁省锦州市 121000 shengyuwen@163.com.cn
  • 作者简介:张华锋，男，1979年生，山东省临沂市人，汉族，2010年辽宁医学院研究生院毕业，硕士，医师，主要从事泌尿系疾病方面的研究。zhanghuafeng09@yahoo.cn

Research and progress of cancer stem cells and tumor angiogenesis

Zhang Hua-feng, Sheng Yu-wen, Jiang Hua-mao   

  1. Department of Urology Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
  • Online:2010-03-05 Published:2010-03-05
  • Contact: Sheng Yu-wen, Professor, Department of Urology Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China shengyuwen@163.com.cn
  • About author:Zhang Hua-feng, Master, Physician, Department of Urology Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China zhanghuafeng09@yahoo.cn

PDF

464

被引次数

8

摘要：

背景：最近研究结果证实，肿瘤中存在一小部分肿瘤干细胞，肿瘤干细胞兼有成体干细胞和胚胎干细胞的自我更新和多能性特征，在肿瘤发展中起重要作用。血管内皮生长因子可调节内皮增殖、血管生成，调节血管通透性及血栓形成。
目的：文章就肿瘤干细胞与肿瘤血管生成的研究进展做一综述。
方法：应用计算机检索Pubmed数据库(2000-01/2009-10)，以“Cancer stem cells，Vascular endothelial growth factor，New vascularize”为检索词；同时应用计算机检索CNKI数据库(2000-01/2009-10)和万方数据库(2000-01/2009-10)，以“肿瘤干细胞血、管内皮生长因子、新生血管化”为检索词。
结果与结论：计算机初检得到153篇，中文13篇，英文140 篇。阅读标题和摘要进行初筛，排除因研究目的与此文无关的35篇，内容重复性文献30篇，Meta分析57篇，共保留31篇做进一步分析。由多种因素调控的血管新生是肿瘤生长和转移过程中的必需环节，干细胞参与并促进肿瘤血管新生，从而促进肿瘤的生长和转移，而修饰后的干细胞则可以起到反向的作用。同时，干细胞也可以作为治疗物质的载体定位肿瘤病灶，特别是在寻找亚临床病灶及远处转移病灶方面具有潜在的优越性。

关键词: 血管内皮生长因子, 新生血管化, 细胞移植, 肿瘤干细胞, 综述文献

Abstract:

BACKGROUND: Recent investigations show that there are a small part of self-renewing and multi-potent cells named as tumor stem cells. Those cells share many characteristics with somatic and embryonic stem cells and are thought to be responsible for driving tumor progression in growing list of neoplastic diseases. Vascular endothelial growth factor (VEGF) is an important angiogenesis factor, which can regulate endothelial proliferation, angiogenesis, permeability of blood vessel, and thrombogenesis.
OBJECTIVE: To summarize the progress of cancer stem cells and tumor angiogenesis.
METHODS: A computer-based online search was conducted in PUMMED, CNKI, and Wanfang databases with the key words of “cancer stem cells, vascular endothelial growth factor, new vascularize” in both Chinese and English from January 2000 to October 2009.
RESULTS AND CONCLUSION: Among 153 articles, there were 13 in Chinese and 140 in English. Titles and abstracts were preliminarily screened, and articles which were non-relative (n=35), duplicated (n =30), and Meta analysis (n =57), were excluded. A total of 31 articles were included in the final analysis. Angiogenesis regulated by multiple factors was a necessary link for tumor growth and transferring. Stem cells promoted angiogenesis, thereby promoted tumor growth and transferring. However, the modified stem cells caused the opposite effects. On the other hand, the stem cells were considered as a substance vector to localize tumor focus, in particular, it will be potential for looking for subclinical focus and distal focus.

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