中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (3): 505-508.doi: 10.3969/j.issn.1673-8225.2010.03.030

• 生物材料综述 biomaterial review • 上一篇    下一篇

生物材料中基体及涂层材料的理论研究与进展

王文静，黄剑锋，李颖华，曹丽云   

  1. 教育部轻化工助剂化学与技术重点实验室，陕西科技大学，陕西省西安市   710021
  • 出版日期:2010-01-15 发布日期:2010-01-15
  • 通讯作者: 黄剑锋，博士，教授，博士生导师，教育部轻化工助剂化学与技术重点实验室，陕西科技大学，陕西省西安市 710021 huangjf@sust.edu.cn
  • 作者简介:王文静★，女，1985年生，陕西省渭南市人，汉族，陕西科技大学在读硕士，主要从事功能薄膜与涂层材料(生物涂层)研究。 wangwenjinggb@163.com
  • 基金资助:

    课题由陕西省教育厅自然科学专项基金(08JK220)；教育部新世纪优秀人才支持计划(ENCT–06–0893)；陕西科技大学博士科研创新基金(BS09–09)；陕西省自然科学基金(SJ08–ZT05)；陕西科技大学研究生创新基金等基金赞助。

Theoretical research and progress of basal body and bio-coatings in biomaterial field

Wang Wen-jing, Huang Jian-feng, Li Ying-hua, Cao Li-yun   

  1. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi’an  710021, Shaanxi, China
  • Online:2010-01-15 Published:2010-01-15
  • Contact: Huang Jian-feng, Doctor, Professor, Doctoral supervisor, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi’an 710021, Shaanxi, China huangjf@sust.edu.cn
  • About author:Wang Wen-jing★, Studying for master’s degree, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi’an 710021, Shaanxi, China wangwenjinggb@163.com
  • Supported by:

     the Natural Science Foundation of Shaanxi Educational Commission, No. 08JK220*; Program for Excellent New Century Talents in University, No. ENCT-06-0893*; Doctoral Scientific Program in Shaanxi University of Science & Technology, No. BJ08-09*; Natural Science Foundation of Shaanxi Province, No. SJ08-ZT05-3*; Innovation Program for Graduates in Shaanxi University of Science & Technology*

PDF

541

被引次数

11

摘要：

背景：在生物材料特别是生物涂层领域的研究中，寻找一种既具有优良生物性能又具有良好力学性能的基体材料并以适当的方法制备出表面均匀致密、结合力较高的涂层是限制人工假体能否真正应用于临床的一个关键因素。
目的：对生物涂层材料的研究进展做一综述。
方法：应用计算机检索CNKI、中国标准全文数据库和Science Direct数据库中1998-01/2009-10关于生物材料的文章，在标题和摘要中以“生物涂层，羟基磷灰石，钛合金，碳/碳复合材料”或“Biocoatings;HAp;Titanium; Carbon/carbon composites”为检索词进行检索。选择文章内容与生物涂层材料有关者，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到216篇文献，根据纳入标准选择关于生物涂层材料的31篇文章进行综述。
结果与结论：通过对钛合金与碳/碳复合材料两种基体材料以及各种涂层制备工艺的对比发现，碳/碳复合材料作为基体材料，不但具有很好的生物相容性，而且与天然骨的力学强度匹配，利用水热电泳沉积技术，结合羟基磷灰石、壳聚糖、有机玻璃等涂层材料的生物性能，制备以碳/碳为基体的复合涂层，有望为提高涂层与基体的结合强度提供新的思路和方法。

关键词: 生物涂层, 羟基磷灰石, 钛合金, 碳/碳复合材料, 水热电泳沉积

Abstract:

BACKGROUND: In the research of biomaterial, especially bio-coatings field, how to find a good biological and mechanical properties basal body, and to prepare coatings with uniform and compact surface and strong bonding force, is the key factor in clinical Application of artificial prosthesis.
OBJECTIVE: To review the progress of bio-coatings.
METHODS: Databases of CNKI, VIP, and Science Direct were retrieved with key words of “Biocoatings, HAp, Titanium, Carbon/carbon composites” to search pApers published from January 1998 to October 2009. PApers underlying bio-coatings were selected. Totally 216 literatures were initial searched, according to inclusive criteria, 31 literature were summarized. 
RESULTS AND CONCLUSION: By contrasting the basal bodies made of titanium or carbon/carbon and different coating preparation, we found that the basal body composed of carbon/carbon composites exhibited good biocompatibility, which had similar strength to natural bone. Using hydrothermal method, the composites coating prepared by taking carbon/carbon as basal body and hydroxyApatite, chitosan, or polymethyl methacrylate as coatings provided a new idea for increasing the combing strength between coatings and basal body.

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