中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (1): 175-178.doi: 10.3969/j.issn.1673-8225.2010.01.037

• 干细胞综述 • 上一篇    下一篇

神经干细胞在神经系统疾病中的应用

孟红旗1，全亚萍2   

  1. 1佛山大学医学院医学系神经病学研究室，广东省佛山市  528000； 
    2南京中医药大学附属泰州医院神经内科，江苏省泰州市  225300
  • 出版日期:2010-01-04 发布日期:2010-01-04
  • 作者简介:孟红旗，男，1959年生，安徽省亳州市人，汉族，1984年安徽医科大学毕业，硕士，教授，主任医师，主要从事神经病学方面的研究。 baimaobenben@126.com

Application of neural stem cells in nervous system diseases

Meng Hong-qi1, Quan Ya-ping2   

  1. 1Research Laboratory of Neurology, Department of Medicine, Medical College of Foshan University, Foshan   528000, Guangdong Province, China;
    2Department of Neurology, Affiliated Taizhou Hospital, Nanjing University of Chinese Medicine, Taizhou   225300, Jiangsu Province, China
  • Online:2010-01-04 Published:2010-01-04
  • About author:Meng Hong-qi, Master, Professor, Chief physician, Research Laboratory of Neurology, Department of Medicine, Medical College of Foshan University, Foshan 528000, Guangdong Province, China baimaobenben@126.com

PDF

655

被引次数

19

摘要：

背景：神经干细胞的临床应用与基因治疗的有机结合可用于治疗多种神经系统遗传性和获得性疾病，但神经系统疾病多种多样，不同疾病神经组织内环境也不同，它们均影响神经干细胞的治疗效果。神经干细胞基因治疗中，如能同时转入多种外源性基因，让其相互作用及调节，就能更有效地促进神经组织不断再生。

目的：文章就神经干细胞在神经系统疾病方面的应用进行综述。

方法：应用计算机检索Medline数据库(2000-01/2009-08)，以“Neural stem cells，Gene，Nervous system diseases”为检索词；应用计算机检索清华同方数据库(2000-01/2009-08)，以“神经干细胞、基因、神经系统疾病”为检索词。

结果与结论：计算机初检得到88篇英文文献，阅读标题和摘要进行初筛，排除因研究目的与此文无关的20篇，内容重复性的研究28篇，共保留40篇文献进行综述。神经干细胞作为一种新型的治疗手段，已用作供体细胞或转基因载体，对脑血管病、脑损伤性疾病、脊髓损伤、神经变性病、脑肿瘤、遗传代谢性疾病等治疗均取得了一定效果，但神经干细胞增殖、分化、迁移调控机制的基础性研究还有许多关键问题没有解决，不同疾病神经组织内的微环境亦影响着神经干细胞的治疗。

关键词: 基因, 神经系统疾病, 神经干细胞, 干细胞, 综述文献

Abstract:

BACKGROUND: The clinical application of neural stem cells (NSCs) in combination with gene therapy could be used to treat a variety of nervous system hereditary and acquired diseases. However, nervous system diseases are varying. Nerve tissue internal environment of distinctive diseases is also different. All these factors affect the therapeutic effect of NSCs. Moreover, interaction and regulation of a variety of exogenous genes in NSC gene therapy would greatly promote continued regeneration of nerve tissue.

OBJECTIVE: To review application of NSCs in the nervous system diseases.

METHODS: A computer-based online search of Medline database (2000-01/2009-08) and Tongfang database (2000-01/2009-08) was performed for related articles with key words “neural stem cells, gene, nervous system diseases”.

RESULTS AND CONCLUSION: A total of 88 English articles were collected. By reading the title and summary, 20 unrelated articles and 28 repetitive articles were excluded. Finally, 40 were reviewed. NSC as a new-type treatment has been used for somatic cell or transgenic vector, and has achieved a certain effect for cerebrovascular disease, brain damage disease, spinal cord injuries, neurodegenerative diseases, brain tumors, and genetic metabolic diseases. However, many key issues such as NSC proliferation, differentiation, migration and control mechanism have not been resolved. In addition, the microenvironment in nerve tissues with different diseases also influences NSC therapy.

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