中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (10): 2653-2661.doi: 10.12307/2026.628

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

身体活动与神经发生领域的主题演化路径分析

焦静娅1，张业廷2   

  1. 1山西医科大学，山西省晋中市  030600；2中国民用航空飞行学院航空安全保卫学院，四川省广汉市  618307
  • 收稿日期:2025-03-27 接受日期:2025-06-17 出版日期:2026-04-08 发布日期:2025-09-01
  • 通讯作者: 张业廷，博士，副教授，中国民用航空飞行学院航空安全保卫学院，四川省广汉市 618307
  • 作者简介:焦静娅，女，1989年生，山西省太原市人，汉族，2016年北京体育大学毕业，硕士，讲师，主要从事体育与健康方面的研究。
  • 基金资助:
    四川省科技厅课题(2020YFH0184)，项目负责人：张业廷；中央高校基本科研业务费专项资金资助(PHD2023-003)，项目负责人：张业廷

Analysis of thematic evolution pathways in the field of physical activity and neurogenesis

Jiao Jingya1, Zhang Yeting2    

  1. 1Shanxi Medical University, Jinzhong 030600, Shanxi Province, China; 2Aviation Safety and Security College, Civil Aviation Flight University of China, Guanghan 618307, Sichuan Province, China
  • Received:2025-03-27 Accepted:2025-06-17 Online:2026-04-08 Published:2025-09-01
  • Contact: Zhang Yeting, PhD, Associate professor, Aviation Safety and Security College, Civil Aviation Flight University of China, Guanghan 618307, Sichuan Province, China
  • About author:Jiao Jingya, MS, Lecturer, Shanxi Medical University, Jinzhong 030600, Shanxi Province, China
  • Supported by:
    Sichuan Provincial Science and Technology Department, No. 2020YFH0184 (to ZYT); the Fundamental Research Funds for the Central Universities, No. PHD2023-003 (to ZYT)

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摘要：


文题释义：
身体活动：是指人体进行的各种形式的运动，包括日常活动和有计划的运动。身体活动不仅能促进心血管健康、调节代谢、维持体质量，还对脑健康具有显著益处。规律的身体活动可增加脑血流量，促进神经发生和脑可塑性，改善认知功能和记忆力，还能通过减少炎症、调节神经营养因子水平对神经退行性疾病起到预防和延缓作用。
神经发生：是指神经干细胞或神经祖细胞分化为成熟神经元的过程，这一过程贯穿从胚胎发育到成年期的整个生命周期。在胚胎期，神经发生主要负责大脑和神经系统的基础结构构建；而在成年期，神经发生主要集中在特定脑区，如海马的齿状回和侧脑室的室下区。神经发生不仅在正常脑功能中发挥关键作用，还可能与神经退行性疾病和精神障碍密切相关。

背景：神经发生是神经干细胞或神经祖细胞产生新的神经细胞类型的能力。运动可以促进神经发生，但其所涉及的相关机制却还不明朗。近年来，身体活动与神经发生领域的研究不断增多，该领域的研究热点和研究趋势也在不断演变。因此，有必要对该领域的文献进行全面梳理。
目的：通过文献计量学方法，探究身体活动与神经发生领域研究主题的动态演化过程，理清其发展状态及知识结构的变化情况，为进一步的研究提供方向。
方法：基于Web of Science核心合集数据库进行主题词检索，策略为(TS=(“physical exercise” AND neurogenesis) OR TS=(“physical activity” AND neurogenesis) OR TS=(“exercise” AND neurogenesis)) AND 文献类型：(Article OR Review)，依照纳入及排除标准选取2 469篇相关文献为研究内容，并利用SciMAT软件进行可视化分析。
结果与结论：①“身体活动与神经发生”领域可分为“祖细胞”“神经营养因子”“痴呆”“神经祖细胞”“神经前体细胞”“运动干预”和“抗氧化剂”7个主要演化方向，并形成了25条子演化路径；②“丰富环境”“神经营养因子”“认知功能”等主题可能是未来的研究重点；③该研究领域重点关注的人群为老年人、儿童和青少年，重点关注的疾病类型为痴呆，同时探究身体活动促进神经发生的分子生物学机制推动了此领域的深入研究。
https://orcid.org/0009-0003-2212-3634(焦静娅)

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 身体活动, 运动干预, 神经发生, 文献计量学, 研究热点, SciMAT

Abstract:

BACKGROUND: Neurogenesis is the ability of neural stem cells, or neural progenitors, to generate new nerve cell types. Exercise has been shown to promote neurogenesis; however, the underlying mechanisms involved remain unclear. In recent years, research on the relationship between physical activity and neurogenesis has been increasing, with evolving research hotspots and trends in this field. Therefore, it is necessary to conduct a comprehensive review of the literature in this field.

OBJECTIVE: To explore the dynamic evolution of research topics in the field of physical activity and neurogenesis using bibliometric methods, and to clarify its developmental status and changes in knowledge structure, thereby providing guidance for future research directions.
METHODS: Based on the Web of Science Core Collection database, the search strategy for the topic terms was defined as: TS=(“physical exercise” AND neurogenesis) OR TS=(“physical activity” AND neurogenesis) OR TS=(“exercise” AND neurogenesis), with the document types limited to (Article OR Review). Following the inclusion and exclusion criteria, 2 469 relevant documents were selected as the research dataset, and SciMAT software was employed for visualization analysis.
RESULTS AND CONCLUSION: The field of “physical activity and neurogenesis” can be categorized into seven major evolutionary directions: “progenitor cells,” “neurotrophic factors,” “dementia,” “neural progenitor cells,” “neural precursor cells,” “exercise interventions,” and “antioxidants,” which collectively form 25 sub-evolutionary pathways. Topics such as “enriched environment,” “neurotrophic factors,” and “cognitive function” are likely to become future research focuses. This field primarily targets populations such as older adults, children, and adolescents, with a specific emphasis on diseases like dementia. Moreover, exploring the molecular biological mechanisms through which physical activity promotes neurogenesis has significantly advanced research in this field.


Key words: physical activity, exercise intervention, neurogenesis, bibliometrics, research hotspots, SciMAT

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