中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (27): 4413-4420.doi: 10.12307/2024.558
• 组织构建综述 tissue construction review • 上一篇 下一篇
孔健达1,解瑛傲2,马 雯3,刘友涵3,王清路3
收稿日期:
2023-10-07
接受日期:
2023-11-06
出版日期:
2024-09-28
发布日期:
2024-01-29
通讯作者:
王清路,博士,教授,山东体育学院体育科学研究院,山东省济南市 250000
作者简介:
孔健达,男,1999年生,山东省青岛市人,汉族,曲阜师范大学体育科学学院在读硕士,主要从事运动干预慢性病相关研究。
解瑛傲,女,1999年生,济宁医学院在读硕士,山东省青岛市人,汉族,主要从事神经肌肉疾病临床治疗与机制的研究。
基金资助:
Kong Jianda1, Xie Yingao2, Ma Wen3, Liu Youhan3, Wang Qinglu3
Received:
2023-10-07
Accepted:
2023-11-06
Online:
2024-09-28
Published:
2024-01-29
Contact:
Wang Qinglu, PhD, Professor, Sports Science Research Institute, Shandong Sport University, Jinan 250000, Shandong Province, China
About author:
Kong Jianda, Master candidate, School of Sports Science, Qufu Normal University, Jining 272000, Shandong Province, China
Xie Yingao, Master candidate, Clinical Medical College, Jining Medical University, Jining 272000, Shandong Province, China
Supported by:
摘要:
文题释义:
线粒体功能障碍:线粒体内部发生了一系列的异常变化,导致线粒体无法正常工作以及产生足够的能量。线粒体功能障碍可以是先天性的遗传性疾病,也可以是后天性的获得性疾病,如细胞内毒素作用、药物中毒及代谢紊乱等。
背景:帕金森病是一种神经退行性疾病,其发病机制涉及线粒体功能障碍,运动对帕金森病相关线粒体功能障碍具有潜在的改善作用,但目前尚无综述对这一领域进行综合回顾和深入分析。
目的:综合回顾并深入分析帕金森病相关线粒体功能障碍及运动对其潜在的改善作用,旨在为帕金森病的治疗和预防提供新的思路和方法。结果与结论:①帕金森病与线粒体功能障碍密切相关,包括帕金森病患者体内线粒体生物发生受阻、自噬减少、细胞凋亡增加、Ca2+浓度异常升高和氧化应激增加等现象。②运动对帕金森病相关的线粒体功能障碍有着正面的改善作用,通过促进线粒体生物发生、自噬和调节线粒体形态,改变线粒体呼吸链的可塑性,减少氧化应激,从而有助于改善帕金森病相关的发展和进展。③然而,目前线粒体功能障碍与运动对其的改善作用之间的详细机制仍不完全清楚,未来可开展临床研究验证动物模型结果,深入了解运动对帕金森病患者的益处及机制。
https://orcid.org/0000-0003-1783-918X(孔健达);https://orcid.org/0009-0005-0223-7532(解瑛傲);
https://orcid.org/0000-0002-2891-9399(王清路)
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
中图分类号:
孔健达, 解瑛傲, 马 雯, 刘友涵, 王清路. 帕金森病相关线粒体功能障碍及运动对其潜在的改善作用[J]. 中国组织工程研究, 2024, 28(27): 4413-4420.
Kong Jianda, Xie Yingao, Ma Wen, Liu Youhan, Wang Qinglu. Mitochondrial dysfunction in Parkinson’s disease and the potential ameliorative effects of exercise[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(27): 4413-4420.
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1.1.6 检索策略 运用布尔逻辑运算符“OR”和“AND”分别将检索词连接进行检索,以PubMed和中国知网数据库为例,文献检索的详细策略见图1。
1.1.7 检索文献量 最终检索获得文献5 590篇,包括中文文献2 557篇、英文文献3 033篇。中国知网数据库检索获得580篇,万方数据库检索获得823篇,维普数据库检索获得1 154篇;Web of Science数据库检索获得1 567篇,PubMed数据库检索获得1 466篇。
1.3 文献质量评价和数据的提取 初步共检索到文献5 590篇,严格按照纳入和排除标准进行筛选,最终纳入文献89篇。文献筛选流程图见图2。
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文题释义:
线粒体功能障碍:线粒体内部发生了一系列的异常变化,导致线粒体无法正常工作以及产生足够的能量。线粒体功能障碍可以是先天性的遗传性疾病,也可以是后天性的获得性疾病,如细胞内毒素作用、药物中毒及代谢紊乱等。研究表明,运动在改善帕金森病患者的线粒体功能障碍方面具有积极的作用,其通过多种机制影响线粒体功能,包括促进线粒体生物发生、调节线粒体自噬、影响线粒体形态和提高线粒体呼吸链的可塑性等。目前,已有多项研究报道了帕金森病相关线粒体功能障碍以及运动对这些线粒体功能障碍的改善作用,但尚缺乏相关综述对这一领域进行综合回顾并深入分析。在当前的综述中,主要聚焦于线粒体功能障碍在帕金森病形成中的重要性,并提及了一些已进入临床试验阶段的药物,或探讨了帕金森病中线粒体功能障碍的多个方面,包括环境、遗传和生物因素的影响,以及多个线粒体分子机制,或强调线粒体功能障碍在帕金森病中的复杂性和重要性,并讨论了多个线粒体功能异常的治疗靶点和治疗策略。然而,这些综述未提及运动对促进线粒体生物发生、诱导线粒体自噬、调节线粒体形态、改善线粒体呼吸链的可塑性以及减轻氧化应激等积极影响。
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