中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (29): 4712-4722.doi: 10.12307/2023.663
• 骨与关节综述 bone and joint review • 上一篇 下一篇
田雨一,刘立宏
收稿日期:
2022-08-29
接受日期:
2022-09-28
出版日期:
2023-10-18
发布日期:
2022-12-02
通讯作者:
刘立宏,博士,主任医师,中南大学湘雅二医院,湖南省长沙市 410011
作者简介:
田雨一,女,2001年生,湖北省黄冈市人,汉族,中南大学在读硕士,主要从事骨修复材料、骨免疫调节促骨生成方面的研究。
基金资助:
Tian Yuyi, Liu Lihong
Received:
2022-08-29
Accepted:
2022-09-28
Online:
2023-10-18
Published:
2022-12-02
Contact:
Liu Lihong, MD, Chief physician, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
About author:
Tian Yuyi, Master candidate, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Supported by:
摘要:
文题释义:
巨噬细胞极化:巨噬细胞具有高度的可塑性,其在不同微环境刺激下改变其表型,这一动态且迅速的过程称为巨噬细胞极化。巨噬细胞通常极化为M1或M2两种表型,分别释放促炎或抗炎因子,发挥不同的功能。中图分类号:
田雨一, 刘立宏. 巨噬细胞的骨免疫学效应[J]. 中国组织工程研究, 2023, 27(29): 4712-4722.
Tian Yuyi, Liu Lihong. Osteoimmunological effects of macrophages[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(29): 4712-4722.
[1] LEE CZW, GINHOUX F. Biology of resident tissue macrophages. Development. 2022;149(8):dev200270. [2] SCHLUNDT C, FISCHER H, BUCHER CH, et al. The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time. Acta Biomater. 2021;133:46-57. [3] VAN FURTH R, COHN ZA. The origin and kinetics of mononuclear phagocytes. J Exp Med. 1968;128(3):415-435. [4] GINHOUX F, GRETER M, LEBOEUF M, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330(6005):841-845. [5] HASHIMOTO D, CHOW A, NOIZAT C, et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. 2013;38(4):792-804. [6] GOMEZ PERDIGUERO E, KLAPPROTH K, SCHULZ C, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature. 2015;518(7540):547-551. [7] HE S, CHEN J, JIANG Y, et al. Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells. Elife. 2018;7:e36131. [8] BIAN Z, GONG Y, HUANG T, et al. Deciphering human macrophage development at single-cell resolution. Nature. 2020;582(7813): 571-576. [9] WU Y, HIRSCHI KK. Tissue-Resident Macrophage Development and Function. Front Cell Dev Biol. 2021;8:617879. [10] VAROL C, MILDNER A, JUNG S. Macrophages: development and tissue specialization. Annu Rev Immunol. 2015;33:643-675. [11] PÉREZ S, RIUS-PÉREZ S. Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective. Antioxidants (Basel). 2022;11(7):1394. [12] NEGRESCU AM, CIMPEAN A. The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials. Materials (Basel). 2021;14(6): 1357. [13] ORECCHIONI M, GHOSHEH Y, PRAMOD AB, et al. Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages. Front Immunol. 2019;10:1084. [14] FERRANTE CJ, LEIBOVICH SJ. Regulation of Macrophage Polarization and Wound Healing. Adv Wound Care (New Rochelle). 2012;1(1):10-16. [15] CHANMEE T, ONTONG P, KONNO K, et al. Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel). 2014;6(3):1670-1690. [16] GRANEY PL, BEN-SHAUL S, LANDAU S, et al. Macrophages of diverse phenotypes drive vascularization of engineered tissues. Sci Adv. 2020; 6(18):eaay6391. [17] XIE Y, HU C, FENG Y, et al. Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration. Regen Biomater. 2020;7(3):233-245. [18] LOI F, CÓRDOVA LA, ZHANG R, et al. The effects of immunomodulation by macrophage subsets on osteogenesis in vitro. Stem Cell Res Ther. 2016;7:15. [19] SHAPOURI-MOGHADDAM A, MOHAMMADIAN S, VAZINI H, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425-6440. [20] MARTIN KE, GARCÍA AJ. Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies. Acta Biomater. 2021;133:4-16. [21] MURRAY PJ. Macrophage Polarization. Annu Rev Physiol. 2017;79: 541-566. [22] BRÜNE B, WEIGERT A, DEHNE N. Macrophage Polarization In The Tumor Microenvironment. Redox Biol. 2015;5:419. [23] WANG Y, FAN Y, LIU H. Macrophage Polarization in Response to Biomaterials for Vascularization. Ann Biomed Eng. 2021;49(9): 1992-2005. [24] BYLES V, COVARRUBIAS AJ, BEN-SAHRA I, et al. The TSC-mTOR pathway regulates macrophage polarization. Nat Commun. 2013;4:2834. [25] HAN R, GAO J, ZHAI H, et al. RAD001 (everolimus) attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway, elevating Akt activity and polarizing M2 macrophages. Exp Neurol. 2016;280:106-114. [26] LI R, ZHOU R, WANG H, et al.Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. Cell Death Differ. 2019;26(11):2447-2463. [27] JING Y, WU F, LI D, et al. Metformin improves obesity-associated inflammation by altering macrophages polarization. Mol Cell Endocrinol. 2018;461:256-264. [28] WANG Z, LIU M, YE D, et al. Il12a Deletion Aggravates Sepsis-Induced Cardiac Dysfunction by Regulating Macrophage Polarization. Front Pharmacol. 2021;12:632912. [29] XU X, GAO W, LI L, et al. Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway. J Neuroinflammation. 2021;18(1):119. [30] YANG Y, WANG J, GUO S, et al. Non-lethal sonodynamic therapy facilitates the M1-to-M2 transition in advanced atherosclerotic plaques via activating the ROS-AMPK-mTORC1-autophagy pathway. Redox Biol. 2020;32:101501. [31] KOPAN R, ILAGAN MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009;137(2):216-233. [32] ZHAO JL, HUANG F, HE F, et al. Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages. Cancer Res. 2016;76(6):1403-1415. [33] XU L, LI L, ZHANG CY, et al. Natural Diterpenoid Oridonin Ameliorates Experimental Autoimmune Neuritis by Promoting Anti-inflammatory Macrophages Through Blocking Notch Pathway. Front Neurosci. 2019; 13:272. [34] FENG J, DONG C, LONG Y, et al. Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization. Cell Commun Signal. 2019;17(1):60. [35] FENG X, GAO X, WANG S, et al. PPAR-αAgonist Fenofibrate Prevented Diabetic Nephropathy by Inhibiting M1 Macrophages via Improving Endothelial Cell Function in db/db Mice. Front Med (Lausanne). 2021; 8:652558. [36] ZHENG W, ZHOU J, SONG S, et al. Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice. Int J Endocrinol. 2018; 2018:8309723. [37] YANG R, ZHENG Y, WANG Q, et al. Curcumin-loaded chitosan-bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease. Nanoscale Res Lett. 2018;13(1):330. [38] JIANG N, ZHANG L, ZHAO G, et al. Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis. Invest Ophthalmol Vis Sci. 2020;61(8):28. [39] LIU L, GUO H, SONG A, et al. Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathways. BMC Immunol. 2020;21(1):32. [40] LI X, XU M, SHEN J, et al. Sorafenib inhibits LPS-induced inflammation by regulating Lyn-MAPK-NF-kB/AP-1 pathway and TLR4 expression. Cell Death Discov. 2022;8(1):281. [41] HE S, WANG S, LIU S, et al. Baicalein Potentiated M1 Macrophage Polarization in Cancer Through Targeting PI3Kγ/ NF-κB Signaling. Front Pharmacol. 2021;12:743837. [42] PENG X, HE F, MAO Y, et al. miR-146a promotes M2 macrophage polarization and accelerates diabetic wound healing by inhibiting the TLR4/NF-κB axis. J Mol Endocrinol. 2022;69(2):315-327. [43] NING H, CHEN H, DENG J, et al. Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis. Stem Cell Res Ther. 2021;12(1):519. [44] XIAO M, BIAN Q, LAO Y, et al. SENP3 loss promotes M2 macrophage polarization and breast cancer progression. Mol Oncol. 2022;16(4): 1026-1044. [45] SICA A, MANTOVANI A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122(3):787-95. [46] YIN H, ZHANG X, YANG P, et al. RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming. Nat Commun. 2021;12(1):1394. [47] HORTON JE, RAISZ LG, SIMMONS HA, et al. Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science. 1972;177(4051):793-795. [48] ARRON JR, CHOI Y. Bone versus immune system. Nature. 2000;408 (6812):535-536. [49] OKAMOTO K, NAKASHIMA T, SHINOHARA M, et al. Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems. Physiol Rev. 2017;97(4):1295-1349. [50] SCHLUNDT C, FISCHER H, BUCHER CH, et al. The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time. Acta Biomater. 2021;133:46-57. [51] SALHOTRA A, SHAH HN, LEVI B, et al. Mechanisms of bone development and repair. Nat Rev Mol Cell Biol. 2020;21(11):696-711. [52] GUDER C, GRAVIUS S, BURGER C, et al. Osteoimmunology: A Current Update of the Interplay Between Bone and the Immune System. Front Immunol. 2020;11:58. [53] MARUYAMA M, RHEE C, UTSUNOMIYA T, et al. Modulation of the Inflammatory Response and Bone Healing. Front Endocrinol (Lausanne). 2020;11:386. [54] JONES RE, SALHOTRA A, ROBERTSON KS, et al. Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair. Cell Rep. 2019;28(11): 2757-2766.e5. [55] KUSUMBE AP, RAMASAMY SK, ADAMS RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 2014; 507(7492):323-328. [56] HUME DA, LOUTIT JF, GORDON S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue. J Cell Sci. 1984;66:189-194. [57] CHANG MK, RAGGATT LJ, ALEXANDER KA, et al. Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol. 2008;181(2):1232-1244. [58] WINKLER IG, SIMS NA, PETTIT AR, et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood. 2010;116(23):4815-4828. [59] CAO J, ZHANG S, GUPTA A, et al. Sensory Nerves Affect Bone Regeneration in Rabbit Mandibular Distraction Osteogenesis. Int J Med Sci. 2019;16(6):831-837. [60] LIU Z, SUH JS, DENG P, et al. Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells. Stem Cells. 2022;40(9):818-830. [61] BRACCI-LAUDIERO L, DE STEFANO ME. NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems. Curr Top Behav Neurosci. 2016;29:125-152. [62] RIVERA KO, RUSSO F, BOILEAU RM, et al. Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion. Sci Rep. 2020;10(1):22241. [63] LI Z, MEYERS CA, CHANG L, et al. Fracture repair requires TrkA signaling by skeletal sensory nerves. J Clin Invest. 2019;129(12):5137-5150. [64] LEE S, HWANG C, MARINI S, et al. NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma. Nat Commun. 2021;12(1):4939. [65] DELAY L, BARBIER J, AISSOUNI Y, et al. Tyrosine kinase type A-specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis. Pain. 2022;163(7):e837-e849. [66] XU J, LI Z, TOWER RJ, et al. NGF-p75 signaling coordinates skeletal cell migration during bone repair. Sci Adv. 2022;8(11):eabl5716. [67] FRANCO ML, NADEZHDIN KD, LIGHT TP, et al. Interaction between the transmembrane domains of neurotrophin receptors p75 and TrkA mediates their reciprocal activation. J Biol Chem. 2021;297(2):100926. [68] VALLÉS G, BENSIAMAR F, MAESTRO-PARAMIO L,et al. Influence of inflammatory conditions provided by macrophages on osteogenic ability of mesenchymal stem cells. Stem Cell Res Ther. 2020;11(1):57. [69] MAHON OR, BROWE DC, GONZALEZ-FERNANDEZ T, et al. Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner. Biomaterials. 2020;239:119833. [70] ZHANG B, HAN F, WANG Y, et al. Cells-Micropatterning Biomaterials for Immune Activation and Bone Regeneration. Adv Sci (Weinh). 2022; 9(18):e2200670. [71] ZHANG Y, BÖSE T, UNGER RE, et al. Macrophage type modulates osteogenic differentiation of adipose tissue MSCs. Cell Tissue Res. 2017;369(2):273-286. [72] ROMERO-LÓPEZ M, LI Z, RHEE C, et al. Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional In Vitro Bone Model. Tissue Eng Part A. 2020;26(19-20):1099-1111. [73] LOI F, CÓRDOVA LA, ZHANG R, et al. The effects of immunomodulation by macrophage subsets on osteogenesis in vitro. Stem Cell Res Ther. 2016;7:15. [74] SCHLUNDT C, EL KHASSAWNA T, SERRA A, et al. Macrophages in bone fracture healing: Their essential role in endochondral ossification. Bone. 2018;106:78-89. [75] QIAO W, XIE H, FANG J, et al. Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration. Biomaterials. 2021;276:121038. [76] LUQUE-CAMPOS N, BUSTAMANTE-BARRIENTOS FA, PRADENAS C, et al. The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming. Front Immunol. 2021;12:624746. [77] WEISS ARR, DAHLKE MH. Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs. Front Immunol. 2019;10:1191. [78] RANA N, SULIMAN S, MOHAMED-AHMED S, et al. Systemic and local innate immune responses to surgical co-transplantation of mesenchymal stromal cells and biphasic calcium phosphate for bone regeneration. Acta Biomater. 2022;141:440-453. [79] CHEN B, NI Y, LIU J, et al. Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets. Stem Cells Int. 2018;2018:8348121. [80] PAJARINEN J, LIN T, GIBON E, et al. Mesenchymal stem cell-macrophage crosstalk and bone healing. Biomaterials. 2019;196:80-89. [81] CHANG MK, RAGGATT LJ, ALEXANDER KA, et al. Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol. 2008;181(2):1232-1244. [82] BATOON L, MILLARD SM, WULLSCHLEGER ME, et al. CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials. 2019;196:51-66. [83] WANG J, ZHENG Z, HUANG B, et al. Osteal Tissue Macrophages Are Involved in Endplate Osteosclerosis through the OSM-STAT3/YAP1 Signaling Axis in Modic Changes. J Immunol. 2020;205(4):968-980. [84] SUN W, MEEDNU N, ROSENBERG A, et al. B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation. Nat Commun. 2018;9(1):5127. [85] KANESHIRO S, EBINA K, SHI K, et al. IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro. J Bone Miner Metab. 2014;32(4):378-392. [86] HARMER D, FALANK C, REAGAN MR. Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma. Front Endocrinol (Lausanne). 2019;9:788. [87] HAMEISTER R, LOHMANN CH, DHEEN ST, et al. The effect of TNF-α on osteoblasts in metal wear-induced periprosthetic bone loss. Bone Joint Res. 2020;9(11):827-839. [88] WU S, XIAO Z, SONG J, et al. Evaluation of BMP-2 Enhances the Osteoblast Differentiation of Human Amnion Mesenchymal Stem Cells Seeded on Nano-Hydroxyapatite/Collagen/Poly(l-Lactide). Int J Mol Sci. 2018;19(8):2171. [89] YANG D, WAN Y. Molecular determinants for the polarization of macrophage and osteoclast. Semin Immunopathol. 2019;41(5):551-563. [90] BATOON L, MILLARD SM, RAGGATT LJ, et al. Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model. J Bone Miner Res. 2021;36(11):2214-2228. [91] JUNG YK, KANG YM, HAN S. Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis. Immune Netw. 2019;19(1):e2. [92] XU H, ZHAO H, LU C, et al. Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells. Mediators Inflamm. 2016;2016:8048170. [93] TANAKA K, YAMAGATA K, KUBO S, et al. Glycolaldehyde-modified advanced glycation end-products inhibit differentiation of human monocytes into osteoclasts via upregulation of IL-10. Bone. 2019;128:115034. [94] MUÑOZ J, AKHAVAN NS, MULLINS AP, et al. Macrophage Polarization and Osteoporosis: A Review. Nutrients. 2020;12(10):2999. [95] TOKUNAGA T, MOKUDA S, KOHNO H, et al. TGFβ1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression. Int J Mol Sci. 2020;21(3):800. [96] SUN Y, LI J, XIE X, et al. Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups. Front Immunol. 2021;12:778078. [97] BORDUKALO-NIKŠIĆ T, KUFNER V, VUKIČEVIĆ S. The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications. Front Immunol. 2022;13:869422. [98] NIU Y, WANG Z, SHI Y, et al. Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches. Bioact Mater. 2020;6(1):244-261. [99] XIE Y, HU C, FENG Y, et al. Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration. Regen Biomater. 2020;7(3):233-245. [100] ATCHA H, JAIRAMAN A, HOLT JR, et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021;12(1):3256. [101] HE XT, WU RX, XU XY, et al. Macrophage involvement affects matrix stiffness-related influences on cell osteogenesis under three-dimensional culture conditions. Acta Biomater. 2018;71:132-147. [102] SRIDHARAN R, CAVANAGH B, CAMERON AR, et al. Material stiffness influences the polarization state, function and migration mode of macrophages. Acta Biomater. 2019;89:47-59. [103] HOTCHKISS KM, REDDY GB, HYZY SL, et al. Titanium surface characteristics, including topography and wettability, alter macrophage activation. Acta Biomater. 2016;31:425-434. [104] ZHU Y, ZHANG K, ZHAO R, et al. Bone regeneration with micro/nano hybrid-structured biphasic calcium phosphate bioceramics at segmental bone defect and the induced immunoregulation of MSCs. Biomaterials. 2017;147:133-144. [105] TYLEK T, BLUM C, HRYNEVICH A, et al. Precisely defined fiber scaffolds with 40 μm porosity induce elongation driven M2-like polarization of human macrophages. Biofabrication. 2020;12(2):025007. [106] YIN Y, HE X T, WANG J, et al. Pore size-mediated macrophage M1-to-M2 transition influences new vessel formation within the compartment of a scaffold. Applied Materials Today. 2019;18:100466. [107] LI W, DAI F, ZHANG S, et al. Pore Size of 3D-Printed Polycaprolactone/Polyethylene Glycol/Hydroxyapatite Scaffolds Affects Bone Regeneration by Modulating Macrophage Polarization and the Foreign Body Response. ACS Appl Mater Interfaces. 2022;14(18):20693-20707. [108] HAMLET SM, LEE RSB, MOON HJ, et al. Hydrophilic titanium surface-induced macrophage modulation promotes pro-osteogenic signalling. Clin Oral Implants Res. 2019;30(11):1085-1096. [109] SHEN H, SHI J, ZHI Y, et al. Improved BMP2-CPC-stimulated osteogenesis in vitro and in vivo via modulation of macrophage polarization. Mater Sci Eng C Mater Biol Appl. 2021;118:111471. [110] LIU Y, YANG Z, WANG L, et al. Spatiotemporal Immunomodulation Using Biomimetic Scaffold Promotes Endochondral Ossification-Mediated Bone Healing. Adv Sci (Weinh). 2021;8(11):e2100143. [111] LI D, YANG Z, ZHAO X, et al. Osteoimmunomodulatory injectable Lithium-Heparin hydrogel with Microspheres/TGF-β1 delivery promotes M2 macrophage polarization and osteogenesis for guided bone regeneration. Chem Eng J. 2022;135:134991. [112] LI L, LI Q, GUI L, et al. Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis. Bioact Mater. 2022;19:24-37. [113] QI D, SU J, LI S, et al. 3D printed magnesium-doped β-TCP gyroid scaffold with osteogenesis, angiogenesis, immunomodulation properties and bone regeneration capability in vivo. Biomater Adv. 2022;136:212759. [114] WU J, LIU F, WANG Z, et al. The Development of a Magnesium-Releasing and Long-Term Mechanically Stable Calcium Phosphate Bone Cement Possessing Osteogenic and Immunomodulation Effects for Promoting Bone Fracture Regeneration . Front Bioeng Biotechnol. 2022;9:803723. [115] HE Y, YAO M, ZHOU J, et al. Mg(OH)2 nanosheets on Ti with immunomodulatory function for orthopedic applications. Regen Biomater. 2022;9:rbac027. [116] LIANG L, SONG D, WU K, et al. Sequential activation of M1 and M2 phenotypes in macrophages by Mg degradation from Ti-Mg alloy for enhanced osteogenesis. Biomater Res. 2022;26(1):17. [117] BAI X, LIU W, XU L, et al. Sequential macrophage transition facilitates endogenous bone regeneration induced by Zn-doped porous microcrystalline bioactive glass. J Mater Chem B. 2021;9(12):2885-2898. [118] XIN L, LIN X, ZHOU F, et al. A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomater. 2020;113:252-266. [119] CASTAÑO IM, RAFTERY RM, CHEN G, et al. Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells. Acta Biomater. 2020;109:267-279. [120] MENCÍA CASTAÑO I, CURTIN CM, DUFFY GP, et al. Harnessing an Inhibitory Role of miR-16 in Osteogenesis by Human Mesenchymal Stem Cells for Advanced Scaffold-Based Bone Tissue Engineering. Tissue Eng Part A. 2019;25(1-2):24-33. |
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1.1 资料来源
1.1.1 检索人及检索时间 第一作者于2022年6月进行检索。
1.1.2 检索文献时限 2010年1月至2022年8月。
1.1.3 检索数据库 PubMed、Web of Science和CNKI数据库。
1.1.4 检索词 英文检索词为“macrophage polarization,bone,osteogenesis,osteoimmunology,biomaterials,tissue engineering”;中文检索词为“巨噬细胞极化、骨、成骨、骨免疫学、生物材料、组织工程”。
1.1.5 检索文献类型 研究原著和综述。
1.1.6 手工检索情况 手工检索纳入文献中少数年代久远的经典参考文献。
1.1.7 检索策略 以PubMed数据库为例,见图1。
1.1.8 文献检索量 初步检索共获得中文文献126篇,英文文献734篇。
1.2 纳入和排除标准
1.2.1 纳入标准 ①论点、论据可靠且发表在权威、专业的杂志文献;②有关巨噬细胞的骨免疫学效应的文献。
1.2.2 排除标准 重复或与研究内容无关的文献。
1.3 数据提取 共检索到860篇相关文献,排除740篇,实际纳入120篇,文献检索过程见图2。
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文题释义:
巨噬细胞极化:巨噬细胞具有高度的可塑性,其在不同微环境刺激下改变其表型,这一动态且迅速的过程称为巨噬细胞极化。巨噬细胞通常极化为M1或M2两种表型,分别释放促炎或抗炎因子,发挥不同的功能。本文通过综述巨噬细胞的骨免疫学效应研究进展,证实巨噬细胞在骨组织工程中具有巨大潜力,为临床应用巨噬细胞实现骨修复提供理论支持,也为探索其他炎症相关疾病的发病机制和治疗手段提供思路。具体来说,未来可以探寻更多的巨噬细胞调控策略用于实现更佳的骨组织再生和修复,例如细胞因子、药物、miRNA以及生物材料理化性质修饰等手段的单一或联合应用,尤其是基因调控这种新兴方法。此外,由于巨噬细胞广泛的组织分布特性和显著的可塑性,在探讨人体其他组织炎症/自身免疫性疾病的发生、发展及治疗时,可以考虑巨噬细胞的作用。因此,针对上述巨噬细胞的研究方向,未来以下几个方面还需补充研究。第一,成骨细胞、破骨细胞甚至各种干细胞等对巨噬细胞的双向作用;第二,组织巨噬细胞的发育、迁移、组织定植、成熟、凋亡、被取代的具体过程;第三,影响巨噬细胞行为的关键因素及机制。最终,从长远角度看,如何把以上巨噬细胞相关的基础研究逐渐转换成人体内研究并提高研究成果在人体中的实用性是未来研究的一大重难点。
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