中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (32): 5204-5209.doi: 10.12307/2021.225

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨关节炎形成过程中细胞焦亡的作用与机制

智佳佳1，杜朝政1，王宇泽2   

  1. 1山西医科大学，山西省太原市   030001；2山西医科大学第二医院骨科，山西省太原市   030001

  • 收稿日期:2020-09-03 修回日期:2020-09-05 接受日期:2020-10-16 出版日期:2021-11-18 发布日期:2021-07-26
  • 通讯作者: 王宇泽，博士，副主任医师，山西医科大学第二医院骨科，山西省太原市 030001
  • 作者简介:智佳佳，男，1993年生，山西省太原市人，汉族，山西医科大学在读硕士，主要从事骨与软骨损伤的研究。
  • 基金资助:
    山西省青年科技研究基金(201901D211505)，项目负责人：王宇泽

Pyroptosis in the progression of osteoarthritis

Zhi Jiajia1, Du Chaozheng1, Wang Yuze2   

  1. 1Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 2Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2020-09-03 Revised:2020-09-05 Accepted:2020-10-16 Online:2021-11-18 Published:2021-07-26
  • Contact: Wang Yuze, MD, Associate chief physician, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • About author:Zhi Jiajia, Master candidate, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Supported by:
    Shanxi Youth Science and Technology Research Fund, No. 201901D211505 (to WYZ)

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摘要：

文题释义：
细胞焦亡：又称细胞炎性坏死，是一种程序性细胞死亡，表现为细胞不断胀大直至细胞膜破裂，导致细胞内容物的释放进而激活强烈的炎症反应。细胞焦亡是机体一种重要的天然免疫反应，在抗击感染中发挥重要作用。细胞焦亡涉及两个途径：caspase-1介导的典型途径和caspase-4、caspase-5、caspase-11介导的非典型途径。
细胞凋亡：是指为维持内环境稳定，由基因控制的细胞自主的有序的死亡。细胞凋亡与细胞坏死不同，细胞凋亡不是一件被动的过程，而是主动过程，它涉及一系列基因的激活、表达以及调控等的作用；它并不是病理条件下自体损伤的一种现象，而是为更好地适应生存环境而主动争取的一种死亡过程。
背景：研究发现，在骨关节炎的病理进展中，细胞焦亡参与其中并发挥作用。
目的：了解当前细胞焦亡在骨关节炎中的最新研究进展，并探讨他们的关系，为骨关节炎的研究和诊疗提供新的靶点。
方法：从CNKI、万方数据、维普、ScienceDirect、Nature、Springer、PubMed等数据库进行相关文献的检索。中文检索词：骨关节炎、细胞焦亡、核苷酸结合寡聚化结构域样受体蛋白3、核因子κB、半胱天冬酶、白细胞介素、gasdermin D；英文检索词：osteoarthritis(OA)，pyroptosis，nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)，Nuclear factor kappa B(NF-κB)，caspase，interleukin(IL)，gasdermin D(GSDMD)。从被检索出的文献中根据入选标准进行筛选，最终纳入相关文献61篇。
结果与结论：细胞焦亡与骨关节炎中的软骨降解、炎症反应和滑膜的破坏等都有一定的关系。在细胞焦亡激活过程中，所涉及到的一些蛋白和细胞因子均存在差异性表达，如NLRs、caspases、白细胞介素和GSDMD等，虽然已有研究显示它们与骨关节炎的病理发展存在着一定的关系，但其在骨关节炎中的作用机制还未完全了解。

https://orcid.org/0000-0001-9785-3162 (智佳佳  ) 
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


关键词: 骨关节炎, 细胞焦亡, 核苷酸结合寡聚化结构域样受体蛋白3, 核因子κB, 半胱天冬酶, 白细胞介素, gasdermin D

Abstract: BACKGROUND: Recently, it has been discovered that pyroptosis is involved and plays a role in the pathological progress of osteoarthritis.
OBJECTIVE: To understand the latest research progress in the role of cell pyroptosis in osteoarthritis, and to explore their relationship, so as to provide a new target for the research, diagnosis and treatment of osteoarthritis.
METHODS: Relevant literatures were retrieved from databases such as CNKI, WanFang, VIP, ScienceDirect, Nature, Springer, and PubMed. The Chinese and English search terms included osteoarthritis (OA), pyroptosis, nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), nuclear factor kappa B (NF-κB), caspase, interleukin (IL), and gasdermin D (GSDMD). According to the inclusion criteria, 61 relevant literatures were included for further analysis.
RESULTS AND CONCLUSION: Pyroptosis is certainly related to the degradation of cartilage, inflammation, and synovial damage in osteoarthritis. Some proteins and cytokines involved in the activation of pyroptosis activation are differentially expressed, such as NLRs, caspases, interleukins and GSDMD. Although these proteins and cytokines are known to be involved in the pathological progress of osteoarthritis, their mechanism underlying osteoarthritis has not been completely understood.

Key words: osteoarthritis, pyroptosis, nucleotide-binding oligomerization domain-like receptor protein 3, nuclear factor kappa B, caspase, interleukin, gasdermin D

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