Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (21): 3372-3378.doi: 10.3969/j.issn.2095-4344.2682

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Research progress and development space of microRNA in the process of intervertebral disc degeneration

Hu Baoyang1, 2, Yang Xuejun2   

  1. 1Inner Mongolia Medical University, Hohhot 010020, Inner Mongolia Autonomous Region, China; 2Department of Thoracolumbar Spine Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • Received:2019-12-02 Revised:2019-12-05 Accepted:2020-01-10 Online:2020-07-28 Published:2020-04-17
  • Contact: Yang Xuejun, Master, Chief physician, Department of Thoracolumbar Spine Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • About author:Hu Baoyang, Master candidate, Physician, Inner Mongolia Medical University, Hohhot 010020, Inner Mongolia Autonomous Region, China; Department of Thoracolumbar Spine Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81960406

Abstract:

BACKGROUND: Full-understanding of the mechanism of microRNA (miRNA) in the process of intervertebral disc degeneration at the cellular and molecular levels can provides new idea for the early prevention or treatment of a series of spinal diseases to intervertebral disc degeneration.

OBJECTIVE: To summarize the research status of the role of miRNA in the cause and mechanism of intervertebral disc degeneration.

METHODS: A computed-based online retrieval of PubMed, Wanfang and CNKI databases was conducted with the keywords of “miRNA, intervertebral disc degeneration, extracellular matrix, apoptosis, autophagy, cartilage endplate, nucleus pulposus, fibrous ring” in English and Chinese, respectively. Finally 58 eligible articles were included for review.

RESULTS AND CONCLUSION: The role of miRNA in intervertebral disc degeneration has been widely studied, and some of the specific mechanisms have been verified. Most of the studies are limited to the nucleus pulposus, and there are few reports on cartilage endplate and annulus fibrosus. With the in-depth study of miRNA, there is still much space for clinical research.

Key words: miRNA, intervertebral disc degeneration, extracellular matrix, apoptosis, autophagy, cartilage endplate, nucleus pulposus, fibrous ring

CLC Number: