Calcium phosphate as a scaffold for repair of osteochondral defects

doi:10.3969/j.issn.2095-4344.2015.43.024

Abstract

Abstract:

BACKGROUND: Calcium phosphate has the similar mineral component of natural bones with good bioactivity, osteoconductivity and degradability. It has been widely used in bone defect repair and coatings of implants.

OBJECTIVE: To review the major properties of different-phase calcium phosphate and to summarize the application of calcium phosphate in scaffolds for osteochondral tissue engineering.

METHODS: A computer-based search of PubMed, CNKI and VIP database was performed for relevant articles published from January 2000 to February 2015 with the key words of “osteochondral; calcium phosphate (including hydroxyapatite, tricalcium phosphate, calcium polyphosphate); tissue engineering” in Chinese and English, respectively.

RESULTS AND CONCLUSION: Since the calcium phosphate has a variety of phases and crystalline types, a variety of materials with different structure and size can be obtained using different techniques, such as hydroxyapatite, tricalcium phosphate, calcium polyphosphate, amorphous calcium phosphate. These materials have some differences in their biological and mechanical properties, and hydroxyapatite is the most widely used. Biocomposite scaffolds with calcium phosphates appeared to have promising potential in osteochondral tissue engineering.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Calcium Phosphates, Tissue Engineering, Review

Cai Zhu-yun, Peng Fan, Zi Yun-peng, Wu Hai-shan, Qian Qi-rong . Calcium phosphate as a scaffold for repair of osteochondral defects[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(43): 7017-7022.

Figures/Tables 1

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