Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (43): 7023-7028.doi: 10.3969/j.issn.2095-4344.2015.43.025

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A wound dressing made of nanosilver and bacterial cellulose 

Nan Fang1, Lai Chen2, Xi Ting-fei1, 2   

  1. 1School of Medical Laboratory & Life Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China; 2Biomedical Engineering Research Center, Shenzhen Institute of Peking University, Shenzhen 518057, Guangdong Province, China
  • Received:2015-08-06 Online:2015-10-15 Published:2015-10-15
  • Contact: Xi Ting-fei, Researcher, Doctoral supervisor, School of Medical Laboratory & Life Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China; Biomedical Engineering Research Center, Shenzhen Institute of Peking University, Shenzhen 518057, Guangdong Province, China
  • About author:Nan Fang, Studying for master’s degree, School of Medical Laboratory & Life Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
  • Supported by:

    the Basic Research Project of Shenzhen City, No. JCYJ20130402164725011

Abstract:

BACKGROUND: In recent years, bacterial cellulose modified by nano-composite technology has been endowed with new properties.
OBJECTIVE: To review the combination of bacterial cellulose and nanosilver to prepare wound dressing.
METHODS: A computer-online search was performed in PubMed (2013-01/2015-04) and CNKI (2007-01/2015-04) databases to retrieve studies on bacterial cellulose, nanosilver and their compound method and application using the key words of “bacterial cellulose, nano-silver” in English and Chinese, respectively.
RESULTS AND CONCLUSION: Bacterial cellulose/nano-silver compound can be prepared by three methods: solution impregnation, in situ composite and biocomposite. Solution impregnation method can lower the concentration of nanosilver ions in the fiber matrix to highly control the release of silver ions, but the genetic toxicity and biocompatibility are unclear. In situ composite method can reduce the damage to the mesh structure of cellulose on which silver ions can be bonded firmly to reduce the toxic damage to cells, but the reducing agent used has a higher toxicity, which is difficult to remove. Biocomposite method cannot produce toxic substance, which is friendly to the environment, and the synthetic biomaterials have less harm to the human body and can be controlled highly. 
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Nanostructures, CellulosevBiological Dressings, Tissue Engineering