Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (4): 600-606.doi: 10.3969/j.issn.2095-4344.2375

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Material selection, theoretical design and biomimetic function of artificial periosteum

Chang Wenliao, Zhao Jie, Sun Xiaoliang, Wang Kun, Wu Guofeng, Zhou Jian, Li Shuxiang, Sun Han   

  1. First People’s Hospital of Changzhou, Changzhou 213000, Jiangsu Province, China
  • Received:2020-03-02 Revised:2020-03-07 Accepted:2020-04-18 Online:2021-02-08 Published:2020-11-23
  • Contact: Sun Han, Attending physician, First People’s Hospital of Changzhou, Changzhou 213000, Jiangsu Province, China
  • About author:Chang Wenliao, Master candidate, Physician, First People’s Hospital of Changzhou, Changzhou 213000, Jiangsu Province, China
  • Supported by:
    the Basic Applied Research Project of Changzhou, No. CJ20180063; the Youth Program of National Natural Science Foundation of China, No. 31800806

Abstract: BACKGROUND: Periosteum, as the storage site and recruitment scaffold of progenitor cells and growth factors, plays an important role in the blood supply of bone tissue and the formation and regeneration of bone. Thus, it has become a research hotspot in recent years to develop an artificial periosteum material which can simulate natural periosteum both in structure and function.
OBJECTIVE: To review the research progress of artificial periosteum material and its application in clinical treatment.
METHODS: The relevant documents published by PubMed database up to February 2020 were searched by computer with the search term of “periodium, tissue engineering, artificial, regeneration, repair”.
RESULTS AND CONCLUSION: The artificial periosteum simulates the structure and function of natural periosteum through three elements: scaffolds, cells and factors, which provide a new possibility for the clinical treatment of periosteal tissue repair and bone regeneration. At present, the artificial periosteum can be divided into cell-sheet periosteum material, acellular-scaffold periosteum material and artificially synthetic scaffold periosteum material. Cell-sheet artificial periosteum is relatively simple to prepare and is a kind of tissue engineering periosteum material which has been put into clinical use earlier. Acellular-scaffold artificial periosteum can keep its natural structure or element to the greatest extent. The material of artificially synthetic scaffold is rich and convenient, and has a low incidence of anti-rejection. These materials all showed good osteogenic effect. However, at present, the bionic research on the structure and function of artificial periosteum is still in its infancy, and further improvement is still needed in material selection, theoretical design and other aspects, so as to make it more mature in biological bionic function.

Key words: bone, materials, periosteum, tissue engineering, artificial periosteum, regenerative medicine, defect repair, review

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