Chinese Journal of Tissue Engineering Research ›› 2018, Vol. 22 ›› Issue (14): 2251-2258.doi: 10.3969/j.issn.2095-4344.0754

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Repair materials for bone defects: present status, needs and future developments

Zhou Si-jia1, Jiang Wen-xue2, You Jia2   

  1. 1Tianjin Medical University, Tianjin 300072, China; 2Department of Orthopaedics, Tianjin First Center Hospital, Tianjin 300192, China
  • Received:2017-12-28 Online:2018-05-18 Published:2018-05-18
  • Contact: Jiang Wen-xue, Chief physician, Master’s supervisor, Department of Orthopaedics, Tianjin First Center Hospital, Tianjin 300192, China
  • About author:Zhou Si-jia, Master candidate, TianJin Medical University, Tianjin 300072, China


BACKGROUND: Great development has been made in the research of various repair materials and tissue-engineered bone, and different materials exhibit a strong ability to repair bone defects.

OBJECTIVE: To review the research status and progress of repair materials for bone defects.
METHODS: PubMed, PMC, CBM, CNKI and WanFang databases were used online to retrieve the relative articles regarding repair materials for bone defects published from June 2007 to June 2017. The key words were “biomaterials, bone repair materials, bone substitute, bone tissue engineering, bone defect, bone repair” in English and Chinese, respectively. Finally, 66 eligible articles were included, while the unrelated and repeated ones were excluded.
RESULTS AND CONCLUSION: The main repair materials for bone defects include autologous bone, allogeneic bone, xenogeneic bone, demineralized bone matrix, bioceramics, metal materials, polymer materials, tissue-engineered bone and relative derived composites. Different materials have shown certain advantages and

disadvantages. Clinicians should make an optimal choice in view of the characteristics of materials. Although there is a great progress in the studies of repair materials for bone defects, further investigations are warranted on how to produce highly biomimetic materials, optimize cell adhesion and migration, precisely control the expression and release of related genes and growth factors, validate clinical safety, and provide medical evidence in clinical practice.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Biocompatible Materials, Review, Tissue Engineering

CLC Number: