Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (7): 1112-1117.doi: 10.12307/2024.102

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Role of autophagy in hair regeneration

Huang Yuxin1, Liang Wenzi1, Chen Xiuwen1, Ni Na1, Zhao Yinglin2, Lin Changmin1   

  1. 1Medical College, Shantou University, Shantou 515041, Guangdong Province, China; 2Mental Health Center, Shantou University, Shantou 515065, Guangdong Province, China
  • Received:2022-12-07 Accepted:2023-03-06 Online:2024-03-08 Published:2023-07-17
  • Contact: Lin Changmin, Professor, Doctoral supervisor, Medical College, Shantou University, Shantou 515041, Guangdong Province, China
  • About author:Huang Yuxin, Master candidate, Medical College, Shantou University, Shantou 515041, Guangdong Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 007-41369023 (to LCM)

Abstract: BACKGROUND: Autophagy has become a rapidly developing research hotspot in the biomedical fields. Many researchers are actively exploring the molecular regulatory mechanism of autophagy in a variety of diseases. However, the role of autophagy in hair growth is still unknown. 
OBJECTIVE: To review the current research progress and application value of autophagy in hair growth and regeneration, to understand the role of autophagy in hair growth, to explore the pathogenesis of autophagy in pathological hair loss, and to provide new ideas for the study of drugs for hair loss.
METHODS: Using “hair follicle growth, hair growth, hair regeneration, autophagy associated proteins, autophagy activity, autophagy associated genes, autophagy” as Chinese search terms and “hair growth, hair follicle, hair regeneration, autophagy” as English search terms, PubMed and CNKI databases were searched. The research progress on autophagy, hair growth and the role of autophagy in hair growth in and outside China in recent years was reviewed and summarized. Articles incompatible with the subject content of the paper were excluded. Finally, 78 articles were included for the result analysis.
RESULTS AND CONCLUSION: (1) Autophagy is a normal metabolic process in eukaryotes with complex molecular mechanisms and functional properties, which is beneficial to cell survival and cell death. (2) Alopecia-related diseases are associated with changes in autophagy activity, which can regulate hair growth cycle. Knockout or overexpression of autophagy-related genes can change the state of hair growth. Multiple autophagy related signaling pathways have been found to be related to hair follicle growth. Activators or inhibitors of autophagy can be used to treat or prevent hair loss.

Key words: hair follicle, hair, hair regeneration, hair follicle regeneration, hair follicle growth cycle, autophagy, autophagy activity, autophagy activator, autophagy inhibitor

CLC Number: