中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (41): 7752-7761.doi: 10.3969/j.issn.2095-4344.2012.41.031

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

内皮祖细胞与缺血性脑血管疾病的治疗

赵 瑞，黄清海，赵文元，洪 波，许 奕，刘建民   

  1. 上海长海医院神经外科，全军脑血管病研究所，上海市 200433
  • 收稿日期:2012-02-06 修回日期:2012-07-19 出版日期:2012-10-07 发布日期:2012-10-07
  • 通讯作者: 刘建民，教授，主任医师，博士研究生导师，上海长海医院神经外科，全军脑血管病研究所，上海市 200433 chstroke@163.com
  • 作者简介:赵瑞☆，男，1979年生，安徽省淮北市人，汉族，2007年解放军第二军医大学毕业，博士，主治医师，主要从事脑血管病的基础研究。 z_ray1979@126.com

Application of endothelial progenitor cells in the treatment of ischemic cerebrovascular disease

Zhao Rui, Huang Qing-hai, Zhao Wen-yuan, Hong Bo, Xu Yi, Liu Jian-min   

  1. Department of Neurosurgery, Changhai Hospital of Shanghai, Shanghai 200433, China
  • Received:2012-02-06 Revised:2012-07-19 Online:2012-10-07 Published:2012-10-07
  • Contact: Liu Jian-min, Professor, Chief physician, Doctoral supervisor, Department of Neurosurgery, Changhai Hospital of Shanghai, Shanghai 200433, China chstroke@163.com
  • About author:Zhao Rui☆, M.D., Attending physician, Department of Neurosurgery, Changhai Hospital of Shanghai, Shanghai 200433, China z_ray1979@126.com

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489

被引次数

2

摘要：

背景：近年来大量基础研究发现，在成年机体的骨髓及外周血中均能找到内皮祖细胞，其在成体病理条件下对血管再生与新生过程起着重要作用。脑梗死发生后，在缺血部位存在着新血管形成，而此过程同样存在着内皮祖细胞的参与，内皮祖细胞的增加以及最大程度参与到新血管组织中，这些很可能是脑血管疾病治疗的一条重要途径。
目的：以文献资料分析法探讨分析内皮祖细胞的特性和作用，及其在缺血性脑血管疾病中的应用进展。
方法：检索SCI数据库、CNKI数据库2002至2011年有关内皮祖细胞与缺血性脑血管疾病治疗的相关文献，检索词为“内皮祖细胞(endothelial progenitor cells, EPCs)；前体细胞(precursor cell)；脑卒中(stroke)；脑缺血(brain ischemia, cerebral ischemia)；脑梗死(cerebral infarction，CI)；缺血性脑血管病(ischemic cerebral vascuIar disease)”，以文字和图表形式进行结果的统计和计量分析，描述其分布特征。
结果与结论：内皮祖细胞是成年个体骨髓中的前体细胞，能迁移至外周血并分化为成熟血管内皮细胞，具有良好的增殖潜能，并参与血管内皮修复、缺血器官的新血管形成。根据内皮祖细胞的生物特性与作用，目前国内外研究发现内皮祖细胞能防治脑动脉粥样硬化，参与脑缺血后血管再生，预测评估脑缺血病情，以及对脑出血后具有一定的治疗作用。因此，内皮祖细胞在缺血性脑血管疾病治疗中展现出广泛的应用前景。

关键词: 内皮祖细胞, 前体细胞, 脑卒中, 脑缺血, 脑梗死, 缺血性脑血管病, 脑血管病, 文献计量

Abstract:

BACKGROUND: Previous studies have found that bone marrow and peripheral blood endothelial progenitor cells play an important role in angiogenesis in the adult under pathological conditions. There was the formation of new blood vessels in the ischemic area after cerebral infarction, so endothelial progenitor cells were also involved in this process. The increase of endothelial progenitor cells numbers, as well as the maximum degree of participation in the organization of new blood vessels, provides an important way for the treatment of cerebrovascular disease.
OBJECTIVE: To multivariately analyze the literature on the application of endothelial progenitor cells in the treatment of cerebrovascular disease through SCI database and CNKI database in order to understand the trend of endothelial progenitor cells in the treatment of cerebrovascular disease, the characteristics of endothelial progenitor cells, and the role of data analysis and its application in patients with cerebrovascular disease progress.
METHODS: A retrieval was performed for the literature of the application of endothelial progenitor cells in the treatment of cerebrovascular disease, using key words “endothelial progenitor cells, precursor cell, stroke, brain ischemia or cerebral ischemia, cerebral infarction, ischemic cerebral vascuIar disease” during 2002-01 and 2011-12 in Scopus database and CNKI database. The retrieval results were analyzed, and the trends were described in words and graphics.
RESULTS AND CONCLUSION: Endothelial progenitor cells are bone marrow precursor cells in adults, which can migrate to the peripheral blood and differentiate into mature endothelial cells. They have proliferative potential and can participate in the vascular endothelial repair and new blood vessel formation in ischemic organs. According to the biological properties and role of endothelial progenitor cells, the present study found that endothelial progenitor cells can prevent cerebral artery atherosclerosis, and angiogenesis after focal cerebral ischemia, the forecast evaluation of cerebral ischemic disease, and cerebral hemorrhage after treatment. Thus, endothelial progenitor cells in the treatment of cerebrovascular disease show a wide range of applications.

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