中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (3): 432-439.doi: 10.3969/j.issn.2095-4344.2014.03.017
• 生物材料综述 biomaterial review • 上一篇 下一篇
马文辉,张英泽
出版日期:
2014-01-15
发布日期:
2014-01-15
作者简介:
马文辉,男,1973年生,河北省石家庄市人,汉族,河北医科大学在读博士,主要从事创伤及组织工程材料研究。
基金资助:
河北省科技厅重大项目(12966116d)
Ma Wen-hui, Zhang Ying-ze
Online:
2014-01-15
Published:
2014-01-15
About author:
Ma Wen-hui, Studying for doctorate, Department of Orthopaedic Surgery, the Third Hospital of Hebei Medical University, Key Laboratory of Orthopedic Biomechanics in Hebei Province, Shijiazhuang 050051, Hebei Province, China
Supported by:
the Major Project of Hebei Science and Technology Bureau, No. 12966116d
摘要:
背景:镁是一种高强度的轻量金属,可在生物环境下降解,具有较好的生物相容性,是一种极具潜力的生物医学材料。但其在生理环境下的快速腐蚀一直是限制其临床应用的主要障碍。另外,镁在许多生物学反应及骨代谢的调节中发挥着重要作用。 目的:回顾总结镁金属的应用进展及其在体内的生理作用与机制,并对其调节骨代谢的研究进行综述。 方法:总结并归纳发表于相关核心期刊上的关于镁金属材料研究及镁调节细胞生理和骨代谢的文献。对于以镁金属作为辅助材料或未将镁作为细胞生理调节主要研究对象的文献则不予参考,另外,特别关注镁对骨代谢相关细胞生理调节的文献。 结果与结论:通过对文献的复习可知,可降解镁合金是一类具有临床应用潜力的新型生物移植材料,并且,镁是活细胞内含量最丰富的阳离子之一,是每个生物学过程所必需的一种辅助因子,镁缺乏可引起包括骨质疏松在内的多种疾病,它可通过多种机制调节骨的转化。但关于镁材料的性质及镁对机体生理活动和骨代谢的调节机制仍有许多问题尚不清楚,还需要更深入的研究。同时,了解镁离子对骨生理的影响,对于镁金属的临床应用也具有重要意义。
中图分类号:
马文辉,张英泽. 镁金属生理作用及其调节骨代谢效应[J]. 中国组织工程研究, 2014, 18(3): 432-439.
Ma Wen-hui, Zhang Ying-ze. Development in physiological regulation and bone metabolism of magnesium[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(3): 432-439.
[1]Staiger MP,Pietak AM,Huadmai J,et al.Magnesium and its alloys as orthopedic biomaterials: A review. Biomaterials.2006; 27(9):1728-1734.[2]Witte F,Hort N,Vogt C,et al.Degradable biomaterials based on magnesium corrosion.Curr Opin Solid State Mater Sci.2008; 12:63-72.[3]Hort N,Huang Y,Fechner D,et al.Magnesium alloys as implant materials – Principles of property design for Mg-RE alloys. Acta Biomaterialia.2010; 6:1714-1725.[4]Pollock TM. Weight loss with magnesium alloys. Science. 2010; 328:986-987.[5]Erbel R,Di Mario C,Bartunek J,et al.Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial.Lancet. 2007; 369:1869-1875.[6]Witte F. The history of biodegradable magnesium implants: A review. Acta Biomaterialia.2010;6(5):1680-1692.[7]Witte F,Hort N,Vogt C,et al.Degradable biomaterials based on magnesium corrosion.Curr Opin Solid State Mater Sci.2008; 12:63-72. [8]Witte F,Feyerabend F,Maier P,et al.Biodegradable magnesium-hydroxyapatite metal matrix composites. Biomaterials.2007;28(13):2163-2174.[9]Lambotte A. L'utilisation du magnésium comme matériel perdu dans l' ostéosynthèse.Bull Mem Soc Nat Chir.1932; 28:1325-1334.[10]Troitskii VV, Tsitrin DN.The resorbing metallic alloy ‘Osteosinthezit’ as material for fastening broken bone. Khirurgiia.1944;8:41-44.[11]Znamenskii MS.Metallic osteosynthesis by means of an apparatus made of resorbing metal.Khirurgiia.1945;12:60-63.[12]McBride ED.Absorbable metal in bone surgery.J Am Med Assoc.1938;111:2464-2467.[13]Troganov GB,Savitsky E,Mikhailovich T,et al. Magnesium-base alloys for use in bone surgery.US Patent no.3687135, 1972. [14]Serre CM,Papillard M,Chavassieux P,et al.In?uence of magnesium substitution on a collagen-apatite biomaterial on the production of a calcifying matrix by human osteoblasts.J Biomed Mater Res.1998; 42:626-633.[15]Zeng RC,Dietzel W,Witte F,et al.Progress and challenge for magnesium alloys as biomaterials.Adv Eng Mater.2008;10: B3-B14. [16]Gu X,Zheng Y,Cheng Y,et al.In vitro corrosion and biocompatibility of binary magnesium alloys.Biomaterials. 2009;30:484-498. [17]Witte F,Fischer J,Nellesen J,et al.In vitro and in vivo corrosion measurements of magnesium alloys.Biomaterials.2006; 27(7): 1013-1018.[18]Witte F,Kaese V,Haferkamp H,et al.In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials.2005; 26:3557-3563. [19]Kannan MB,Raman RK.In vitro degradation and mechanical integrity of calcium-containing magnesium alloys in modified-simulated body fluid. Biomaterials.2008;29(15): 2306-2314. [20]Li Z,Gu X,Lou S,et al.The development of binary Mg-Ca alloys for use as biodegradable materials within bone. Biomaterials.2008;29(10):1329-1344. [21]Zhang S,Zhang X,Zhao C,et al.Research on an Mg-Zn alloy as a degradable biomaterial.Acta Biomater.2010;6(2): 626-640. [22]Wong HM,Yeung KW,Lam KO,et al.A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. Biomaterials.2010; 31:2084-2096. [23]Xin Y,Jiang J,Huo K,et al.Corrosion resistance and cytocompatibility of biodegradable surgical magnesium alloy coated with hydrogenated amorphous silicon.J Biomed Mater Res A.2009;89:717-726. [24]Xu L,Zhang E,Yang K.Phosphating treatment and corrosion properties of Mg-Mn-Zn alloy for biomedical application.J Mater Sci Mater Med.2009; 20:859-867. [25]Zberg B,Uggowitzer PJ,Löffler JF.Mg-Zn-Ca glasses without clinically observable hydrogen evolution for biodegradable implants. Nat Mater.2009; 8:887-891.[26]Domingo JL. Aluminum and other metals in Alzheimer’s disease: A review of potential therapy with chelating agents. J Alzheimer’s Dis. 2006;10: 331-341. [27]Yun YH,Dong ZY,Lee N,et al.Revolutionizing biodegradable metals. Mater Today.2009;12:22-32. [28]Atiyeh BS,Costagliola M,Hayek SN,et al.Effect of silver on burn wound infection control and healing: Review of the literature. Burns.2007;33(2): 139-148. [29]Tie D,Feyerabend F,Müller WD,et al.Antibacterial biodegradable Mg-Ag alloys.Eur Cell Mater.2013;25:284-298. [30]Paton BE,Kaleko DM,Koval YM,et al.Influence of alloying with silver and tantalum on features of medical- purpose Ti-Ni alloy. Metallofiz Nov Tekhnol-Met Phys Adv Techn.2010;32: 1691-1703.[31]Necula BS,Apachitei I,Tichelaar FD,et al.An electron microscopical study on the growth of TiO2-Ag antibacterial coatings on Ti6Al7Nb biomedical alloy.Acta Biomaterialia. 2011;7:2751-2757. [32].Bosetti M,Massè A,Tobin E,et al.Silver coated materials for external fixation devices: in vitro biocompatibility and genotoxicity. Biomaterials.2002;23(3):887-892. [33]Hardes J,Streitburger A,Ahrens H,et al.The influence of elementary silver versus titanium on osteoblast behaviour in vitro using human osteosarcoma cell lines.Sarcoma.2007; 2007:26539. [34]Drake PL,Hazelwood KJ.Exposure-related health effects of silver and silver compounds: A review.Ann Occup Hyg.2005; 49:575-585.[35]Willumeit R,Fischer J,Feyerabend F,et al.Chemical surface alteration of biodegradable magnesium exposed to corrosion media.Acta Biomater.2011; 7:2704-2715. [36]Feyerabend F,Drücker H,Laipple D,et al.Ion release from magnesium materials in physiological solutions under different oxygen tensions.J Mater Sci Mater Med.2012;23: 9-24. [37]Jang Y,Collins B,Sankar J,et al.Effect of biologically relevant ions on the corrosion products formed on alloy AZ31B: An improved understanding of magnesium corrosion.Acta Biomater.2013. pii: S1742-7061(13)00144-X. doi: 10.1016/j.actbio.2013.03.026. [Epub ahead of print] [38]Rude RK,Shils ME.Magnesium. In Shils ME (ed): “Modern Nutrition in Health and Disease.” Philadelphia, PA: Lippincott, Williams and Wilkins, 2006:223-247. [39]Rude RK.Magnesium deficiency: a heterogeneous cause of disease in humans. J Bone Miner Res.1998;13(4):749-758. [40]Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine: “Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride.” Washington, DC: National Academy Press,1997:190-249. [41]Mountokalakis T,Singhellakis P,Alevizaki C,et al.Relationship between degree of renal failure and impairment of intestinal magnesium absorption. In Seelig MS (ed): “Magnesium in Health and Disease.” New York: Spectrum Publications,Inc. 1980:453-458. [42]Martin BJ.The magnesium load test: experience in elderly subjects. Aging (Milano).1990;2(3):291-296. [43]Rubin H.Central roles of Mg2+ and of MgATP2- in the regulation of protein synthesis and cell proliferation: significance for neoplastic transformation.Adv Cancer Res.2005;93:1-58. [44]Rubin H.Magnesium: The missing element in molecular views of cell proliferation control.Bioessays.2005;27:311-320.[45]Rubin H,Terasaki M,Sanui H.Major intracellular cations and growth control: Correspondence among magnesium content, protein synthesis, and the onset of DNA synthesis in Balb/c 3T3 cells.Proc Natl Acad Sci USA.1979; 76:3917-3921. [46]Rubin H,Terasaki M,Sanui H.Magnesium reverses inhibitory effects of calcium deprivation on coordinate response of 3T3 cells to serum.Proc Natl Acad Sci USA.1978;75:4379-4383. [47]Schreier MH,Staehelin T.Initiation of mammalian protein synthesis: the importance of ribosome and initiation factor quality for the efficiency of in vitro systems.J Mol Biol.1973; 73:329-349. [48]Terasaki M,Rubin H.Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis. Proc Natl Acad Sci USA.1985;82(21):7324-7326. [49]Vidair C,Rubin H.Mg2+ as activator of uridine phosphorylation and other cellular responses to growth factors.Proc Natl Acad Sci USA.2005;102: 662-666. [50]Dennis PB,Jaeschke A,Saitoh M,et al.Mammalian TOR: a homeostatic ATP sensor.Science.2001;294(5544):1102-1105. [51]Lau YT,Yassin RR,Horowitz SB.Potassium salt microinjection into Xenopus oocytes mimics gonadotropin treatment. Science. 1988;240:1231-323. [52]Achs MJ,Garfinkel D.Computer simulation of energy metabolism in anoxic perfused rat heart.Am J Physiol. 1982;232:R164-R174. [53]Grubbs RD. Effect of epidermal growth factor on Mg2+ homeostasis in BC3H-1 myocytes.Am J Physiol.1991; 260:C1158-C1164.[54]Ishijima S,Sonoda T,Tatibana M.Mitogen-induced early increase in cytosolic free Mg2+ concentration in single Swiss 3T3 fibroblasts.Am J Physiol.1991;261:C1074-C1080. [55]Trzeciakiewicz A,Opolski A,Mazur A.TRPM7: a protein responsible for magnesium homeostasis in a cell.Postepy Hig Med Dosw (Online).2005; 59:496-502. [56]Touyz RM.Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Am J Physiol Heart Circ Physiol.2008;294:H1103-1118. [57]Abed E,Moreau R.Importance of melastatin-like transient receptor potential 7 and cations (magnesium, calcium) in human osteoblast-like cell proliferation.Cell Prolif.2007;40: 849-865. [58]Chubanov V,Gudermann T,Schlingmann KP.Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch.2005;451: 228-234. [59]He Y,Yao G,Savoia C,et al.Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II.Circ Res.2005;96:207-215.[60]Clapham DE,Runnels LW,Strubing C.The TRP ion channel family.Nat Rev Neurosci.2001;2(6):387-396. [61]Harteneck C,Plant TD,Schultz G.From worm to man: three subfamilies of TRP channels.Trends Neurosci.2000; 23(4): 159-166. [62]Minke B,Cook B.TRP channel proteins and signal transduction. Physiol Rev. 2002;82(2):429-472.[63]Montell C,Birnbaumer L,Flockerzi V.The TRP channels, a remarkably functional family.Cell.2002;108(5):595-598. [64]Harteneck C.Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol.2005; 371(4):307-314. [65]Fleig A,Penner R.The TRPM ion channel subfamily: molecular, biophysical and functional features.Trends Pharmacol Sci.2004;25:633-639. [66]Nadler MJ,Hermosura MC,Inabe K,et al.LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature. 2001; 411:590-595. [67]Schmitz C,Dorovkov MV,Zhao X,et al.The channel kinases TRPM6 and TRPM7 are functionally nonredundant.J Biol Chem.2005;280:37763-37771. [68]Chubanov V,Waldegger S,Schnitzler M,et al.Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.Proc Natl Acad Sci USA.2004;101: 2894-2899. [69]Baserga R.In: The Biology of Cell Reproduction. Boston: Harvard Univ. Press,1985:138-140. [70]Wallach S.Effects of magnesium on skeletal metabolism. Magnes Trace Elem. 1990;9(1):1-14. [71]Rude RK,Kirchen ME,Gruber HE,et al.Magnesium deficiency-induced osteoporosis in the rat: Uncoupling of bone formation and bone resorption. Magnes Res.1999;12: 257-267. [72]Leidi M,Dellera F,Mariotti M,et al.High magnesium inhibits human osteoblast differentiation in vitro.Magnes Res.2011; 24(1):1-6. [73]Yun Y,Dong Z,Tan Z,et al.Development of an electrode cell impedance method to measure osteoblast cell activity in magnesium-conditioned media. Anal Bioanal Chem.2010; 396:3009-3015. [74]Rude RK.Magnesium homeostasis. In Bilezikian JB, Raisz L, Rodan G (eds): “Principles of Bone Biology,” 3rd ed. San Diego, CA: Academic Press, 2008:487-513.[75]Fatemi S,Ryzen E,Flores J,et al.Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism.J Clin Endocrinol Metab. 1991;73:1067-1072. [76]Litosch I.G protein regulation of phospholipase C activity in a membrane-solubilized system occurs through a Mg2+- and time-dependent mechanism.J Bio Chem.1991;266: 4764-4771. [77]Volpe P,Alderson-Lang BH,Nickols GA.Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release. I. Effect of Mg2+. Am J Physiol. 1990;258:C1077-C1085. [78]Northup JK,Smigel MD,Gilman AG.The guanine nucleotide activating site of the regulatory component of adenylate cyclase: Identification by ligand binding.J Biol Chem。1982; 257:11416-11423. [79]Rude RK,Adams JS,Ryzen E,et al.Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency.J Clin Endocrinol Metab.1985;61(5):933-940. [80]Risco F,Traba ML.Influence of magnesium on the in vitro synthesis of 24, 25-dihydroxyvitamin D3 and 1-α, 25-dihydroxyvitamin D3.Magnesium Res. 1992;5:5-14.[81]Saggese G,Federico G,Bertelloni S,et al.Hypomagnesemia and the parathyroid hormone-vitamin D endocrine system in children with insulin-dependent diabetes mellitus: effect of magnesium administration. J Pediatr.1991;118:220-225. [82]Welsh JJ,Weaver VM.Adaptation to low dietary calcium in magnesium-deficient rats.J Nutr.1988;118(6):729-734.[83]Christiansen P.The skeleton in primary hyperparathyroidism: a review focusing on bone remodeling, structure, mass, and fracture. APMIS Suppl. 2001;102:1-52. [84]Gruber HE,Rude RK,Wei L,et al.Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton.BMC Musculoskelet Disord.2003;17:4-7. [85]Mackie EJ.Osteoblasts: novel roles in orchestration of skeletal architecture.Int J Biochem Cell Biol.2003;35(9): 1301-1305. [86]Park JW,Kim YJ,Jang JH,et al.Osteoblast response to magnesium ion-incorporated nanoporous titanium oxide surfaces.Clin Oral Implants Res.2010;21(11):1278-1287. [87]Park JW,An CH,Jeong SH,et al.Osseointegration of commercial microstructured titanium implants incorporating magnesium: a histomorphometric study in rabbit cancellous bone. Clin Oral Implants Res. 2012;23(3):294-300.[88]Jeon SH,Kim SJ,Kim JS,et al.Immunosuppressant FK506 decreases the intracellular magnesium in the human osteoblast cell by inhibiting the ERK1/2 pathway.Life Sci. 2009;84:23-27.[89]Jeon SH,Lee MY,Kim SJ,et al.Taurine increases cell proliferation and generates an increase in [Mg2+]i accompanied by ERK 1/2 activation in human osteoblast cells.FEBS Lett.2007;22:581:5929-534.[90]Lerner UH.The role of skeletal nerve fibers in bone metabolism. Endocrinologist.2000;10:377-382.[91]McIntosh TK.Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: A review. J Am Chem Soc. 1993; 89:2719-2725.[92]Weglicki WB,Dickens BF,Wagner TL,et al.Immunoregulation by neuropeptides in magnesium deficiency: Ex vivo effect of enhanced substance P production on circulation T lymphocytes from magnesium-deficient mice. Magnes Res. 1996;9:3-11.[93]Kramer JH,Phillips TM,Weglicki WB.Magnesium-deficiency-enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade.J Mol Cell Cardiol.1997;29:97-110.[94]Malpuech-Brugere C,Nowacki W,Rock E,et al.Enhanced tumor necrosis factor-a production following endotoxin challenge in rats is an early event during magnesium deficiency.Biochimicaet Biophysica Acta.1999; 1453:35-40.[95]Nakagawa M,Oono H,Nishio A.Enhanced productrion of IL-1β and IL-6 following endotoxin challenge in rats with dietary magnesium deficiency. J Vet Med Sci.2001;6:467-469.[96]Malpuech-Brugere C,Nowacki W,Daveau M,et al.Inflammatory response following acute magnesium deficiency in the rat. Biochimica Biophysica Acta.2000; 1501:91-98.[97]Rameshwar P,Ganea D,Gascon P.Induction of IL-3 and granulocyte-macrophage colony stimulating factor by substance P in bone marrow cells in partially mediated through the release of IL-1 and IL-6.J Immunol.1994; 152: 4044-4054.[98]Miyaura C,Kusano K,Masuzawa T,et al.Endogenous bone-resorbing factors in estrogen deficiency: cooperative effect of IL-1β and IL-6.J Bone Miner Res.1995;10: 1365-1373.[99]Nanes MS.Tumor necrosis factor-a: molecular and cellular mechanism in skeletal pathology.Gene.2003;321:1-15.[100]Rude RK,Gruber HE,Wei LY,et al.Magnesium deficiency: effect on bone and mineral metabolism in the mouse.Calcif Tiss Int.2003;72:32-41.[101]Rude RK,Gruber HE,Norton HJ,et al.Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism.Osteoporosis Int. 2006; 17:1022-1032.[102]Rude RK,Gruber HE,Norton HJ,et al.Bone loss induced by dietary magnesium reduction to 10% Nutrient Requirement in rats is associated with increase release of substance P and tumor necrosis factor-a.J Nutr.2004;134:79-85.[103]Robert RK,Gruber HE,Norton HJ,et al.Dietary magnesium reduction to 25% of nutrient requirement disrupts bone and mineral metabolism in the rat. Bone.2005;37:211-219.[104]Hofbauer LC,Heufelder AE.The role of receptor activator of nuclear factor-kB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases.J Clin Endocrinol Metab.2000;85:2355-2363.[105]Manolagas SC.Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev.2000;21:115-137.[106]Rude RK,Gruber HE,Wei LY,et al.Immunolocalization of RANKL is increased and OPG decreased during dietary magnesium deficiency in the rat.Nutr Met. 2005;2:1-8. [107]Crespi R,Mariani E,Benasciutti E,et al.Magnesium-enriched hydroxyapatite versus autologous bone in maxillary sinus grafting: combining histomorphometry with osteoblast gene expression profiles ex vivo.J Periodontol.2009;80:586-593.[108]Abed E,Moreau R.Importance of melastatin-like transient receptor potential 7 and magnesium in the stimulation of osteoblast proliferation and migration by platelet-derived growth factor.Am J Physiol Cell Physiol.2009;297:C360-368.[109]Abed E,Labelle D,Martineau C,et al.Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells.Mol Membr Biol.2009;26:146-158.[110]Abed E,Moreau R.Importance of melastatin-like transient receptor potential 7 and cations (magnesium, calcium) in human osteoblast-like cell proliferation.Cell Prolif.2007;40: 849-865. |
[1] | 刘志超, 张 帆, 孙 旗, 康晓乐, 袁巧妹, 柳根哲, 陈 江. 不同静水压下人椎间盘髓核细胞的形态和活性[J]. 中国组织工程研究, 2021, 25(8): 1172-1176. |
[2] | 李 黎, 马 力. 磁性壳聚糖微球固定化乳糖酶及其酶学性质[J]. 中国组织工程研究, 2021, 25(4): 576-581. |
[3] | 王秋霏, 顾 叶, 彭育沁, 薛 峰, 巨 荣, 朱 锋, 王熠军, 耿德春, 徐耀增. 人工假体磨损颗粒作用下Wnt/β-catenin信号通路对成骨细胞的影响[J]. 中国组织工程研究, 2021, 25(24): 3894-3901. |
[4] | 唐小凯, 李伟明. Nel样分子1型蛋白在脊柱融合术后促进骨性融合的作用与机制[J]. 中国组织工程研究, 2021, 25(24): 3914-3920. |
[5] | 刘 鋆, 杨 龙, 王伟宇, 周玉虎, 吴 颖, 卢 涛, 舒莉萍, 马敏先, 叶 川. 聚3-羟基丁酸酯4-羟基丁酸酯/聚乙二醇/氧化石墨烯组织工程支架的制备和性能评价[J]. 中国组织工程研究, 2021, 25(22): 3466-3472. |
[6] | 周安琪, 唐渝菲, 吴秉峰, 向 琳. 骨膜组织工程设计:共性与个性的结合[J]. 中国组织工程研究, 2021, 25(22): 3551-3557. |
[7] | 霍 花, 程余婷, 周 倩, 齐昱晗, 伍 超, 石前会, 杨童景, 廖 健, 洪 伟. 种植体表面药物涂层对骨结合的影响[J]. 中国组织工程研究, 2021, 25(22): 3558-3564. |
[8] | 郎丽敏, 何 生, 姜增誉, 胡奕奕, 张智星, 梁敏茜. 导电复合材料在心肌梗死组织工程治疗领域的应用进展[J]. 中国组织工程研究, 2021, 25(22): 3584-3590. |
[9] | 李 震, 黄永辉, 孙继芾, 孙海涛. 黏着斑激酶诱导小鼠胚胎成纤维细胞成骨分化的作用及机制[J]. 中国组织工程研究, 2021, 25(2): 165-171. |
[10] | 魏 琴, 张 雪, 马 磊, 李志强, 寿 玺, 段明军, 吴 硕, 贾麒钰, 马 创. 血小板衍生生长因子BB诱导大鼠骨髓间充质干细胞向成骨细胞分化[J]. 中国组织工程研究, 2021, 25(19): 2953-2957. |
[11] | 郭志斌, 吴春芳, 刘子洪, 张钰英, 迟博婧, 王 宝, 马 超, 张国彬, 田发明. 辛伐他汀可刺激骨髓间充质干细胞的成骨分化[J]. 中国组织工程研究, 2021, 25(19): 2963-2968. |
[12] | 张红庆, 谢旭芳, 吴晓牧. 干细胞治疗多发性硬化及视神经脊髓炎谱系疾病的有效性和临床应用限制[J]. 中国组织工程研究, 2021, 25(19): 3049-3056. |
[13] | 姜 涛, 凌翠敏, 陈庆真, 杨冰璇, 林燕平, 邵 敏. 淫羊藿苷通过提高自噬促进成骨细胞分化防治骨质疏松[J]. 中国组织工程研究, 2021, 25(17): 2643-2649. |
[14] | 艾力麦尔旦•艾尼瓦尔, 王 玲, 古 丽, 迪丽达尔•塔西甫拉提, 王 珊, 尹宏斌. 转化生长因子β3对成骨细胞增殖和成骨能力的影响[J]. 中国组织工程研究, 2021, 25(17): 2664-2669. |
[15] | 王 亮, 郭玉兴, 吴 训, 黄 华, 袁广银, 张 雷. 新型镁合金支架材料的体外抑菌性能[J]. 中国组织工程研究, 2021, 25(16): 2506-2513. |
1.1 资料来源
1 此问题的已知信息:镁是一种极具潜力的生物医学材料,但镁金属在生理环境下的快速腐蚀一直是限制其临床应用的主要障碍。另外,镁作为一种人体必需的微量元素,在机体的许多生物学反应中发挥着重要作用。 2 文章增加的新信息:文章从镁金属的应用进展、镁在体内的生理作用及其对骨代谢的影响3个方面进行了分析、综述。可知可降解镁合金是一类具有临床应用潜力的新型生物移植材料,并且,镁是活细胞内含量最丰富的阳离子之一,是每个生物学过程所必需的一种辅助因子,镁缺乏可引起包括骨质疏松在内的多种疾病,它可通过多种机制调节骨的转化。 3 临床应用的意义:通过此综述有助于较全面地了解镁金属的生理作用和临床应用前景。但关于镁材料的性质及镁对机体生理活动和骨代谢调节的机制仍有许多问题尚不清楚,需要进一步的研究予以阐明,同时,了解镁离子对骨生理的影响,对于镁金属的临床应用也具有重要意义。
基金资助: 河北省科技厅重大项目(12966116d)
总之,镁是活细胞内含量最丰富的阳离子之一,是每个生物学过程所必需的一种辅助因子,它参与调节上百种酶的作用及各种转运蛋白和离子通道的活化。镁离子还是细胞内游离钙离子和pH值的重要调节因子,而后两者是细胞收缩、分泌、运动和增殖的主要决定因素。再者,镁还可通过多种机制调节骨的代谢。另一方面,可降解的镁合金是一类极具潜力的新型生物移植材料,其在生理环境下的降解产物也主要以离子状态存在和发挥作用。但是关于镁材料的性质及镁对机体生理活动和骨代谢调节的机制仍有许多问题尚不清楚,需要进一步的研究予以阐明,同时,了解镁离子对骨生理的影响,对于镁金属的临床应用也具有重要意义。
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||