中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (32): 6072-6076.doi: 10.3969/j.issn.1673-8225.2011.32.042

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

诱导骨髓间充质干细胞分化移植后的心脏电生理特性

刘博武，吕安林，燕学波，黄  炜，候  婧，李  垚   

  1. 解放军第四军医大学西京医院心内科，陕西省西安市  710032
  • 收稿日期:2011-02-18 修回日期:2011-03-22 出版日期:2011-08-06 发布日期:2011-08-06
  • 通讯作者: 吕安林，副主任医师，副教授，主要从事冠状动脉粥样硬化与医学组织工程方面的研究，第四军医大学西京医院心内科，陕西省西安市 710032
  • 作者简介:刘博武★，男，1985年生，硕士，主要从事心脏电生理特性与医学组织工程方面的研究。

Cardiac electrophysiological characteristics after transplantation of differentiated bone marrow mesenchymal stem cells

Liu Bo-wu, Lü An-lin, Yan Xue-bo, Huang Wei, Hou Jing, Li Yao   

  1. Department of Cardiology, Xijing Hospital Affiliated to Fourth Military Medical University, Xi’an  710032, Shaanxi Province, China
  • Received:2011-02-18 Revised:2011-03-22 Online:2011-08-06 Published:2011-08-06
  • Contact: Lü An-lin, Associate chief physician, Associate professor, Department of Cardiology, Xijing Hospital Affiliated to Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China lvanlin@fmmu.edu.cn
  • About author:Liu Bo-wu★, Master, Department of Cardiology, Xijing Hospital Affiliated to Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China liubowu@fmmu.edu.cn

PDF

418

被引次数

2

摘要：

背景：随着生物技术的发展，使用骨髓间充质干细胞修复心肌梗死后或者心肌肥厚心肌组织的电生理学成为当今研究热点。
目的：概述骨髓间充质干细胞向心肌细胞诱导分化移植后的电生理特征的研究进展。
方法：应用计算机检索PubMed数据库，Springer Link数据库，Science Direct数据库，CNKI数据库2000-01/2010-10文献，检索词分别为“bone marrow mesenchymal stem cells, cardiac/heart, electrophysiology/ electrophysiological characteristics”和“骨髓间充质干细胞，心脏，电生理”。选择骨髓间充质干细胞向心肌细胞诱导分化移植后的电生理特征的文章，无论观察对象是人或者动物均纳入检索标准。排除重复研究或Meta分析类文章。
结果与结论：收集到208篇相关文献，排除162篇不符合标准的文献，共纳入46篇符合标准的文献。经分析得出以下结论：骨髓间充质干细胞诱导分化移植后，在动物试验模型中和心肌梗死或心肌肥厚的患者中均可有效的改善心功能，为心肌病的临床治疗提供了崭新的策略。而移植后所生成的心肌样细胞在改善心脏功能的同时，对心脏电生理也产生了一定的影响。

关键词: 骨髓间充质干细胞, 诱导, 分化, 移植, 电生理特性

Abstract:

BACKGROUND: With the development of biotechnology, the electrophysiology of repairing heart tissues of myocardial infarction or myocardial hypertrophy by using bone marrow mesenchymal stem cell has become a hot spot.
OBJECTIVE: To overview the research progress of cardiac electrophysiological characteristics after transplantation of induced differentiation of bone marrow mesenchymal stem cells into cardiomyocytes.
METHODS: The databases of PubMed, Springer Link, Science Direct and CNKI were retrieved for papers published from January 2000 to October 2010 with the key words of “bone marrow mesenchymal stem cells, cardiac/heart, electrophysiology/electrophysiological characteristics”. The relevant articles concerning cardiac electrophysiological characteristics of induce differentiation and transplantation of bone marrow stem cells were collected.
RESULTS AND CONCLUSION: Totally 208 papers have been searched. Preliminary screening by reading abstracts to exclude 162 papers that study purpose do not coincident with this review either contents duplicated, and internalized 46 papers at last. Bone marrow mesenchymal stem cells after induced differentiation and transplantation could improve heart function of animal experimental model and myocardial infarction or myocardial hypertrophy patients. Although the cardiomyocyte-like cells from bone marrow mesenchymal stem cells could help to improve heart function, the cardiac electrophysiological characteristics may be influenced by them.

中图分类号: