中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (3): 461-464.doi: 10.3969/j.issn.1673-8225.2011.03.020

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

TiN/Ti纳米涂层修饰镍钛合金的体外腐蚀行为

邵安良1，2，成  艳2，3，奚廷斐1，2，3，周  艺3，周  亮1，万子义3   

  1. 1温州医学院信息与工程学院，浙江省温州市  325035
    2北京大学深圳研究院生物医学工程研究中心，广东省深圳市  518057
    3北京大学前沿交叉学科研究院生物医用材料与组织工程中心，北京市  100871
  • 收稿日期:2010-11-06 修回日期:2010-12-29 出版日期:2011-01-15 发布日期:2011-01-15
  • 通讯作者: 成艳，博士，副研究员，北京大学前沿交叉学科研究院生物医用材料与组织工程中心，北京市 100871 chengyan@pku.edu.cn 并列通讯作者：奚廷斐，教授，北京大学前沿交叉学科研究院生物医用材料与组织工程中心，北京市 100871 xitingfei@pku.edu.cn
  • 作者简介:邵安良★，男，1984年生，浙江省宁波市人，汉族，温州医学院信息与工程学院在读硕士，主要从事生物医用材料的研究。 shaoanliang1984@hotmail.com
  • 基金资助:

    国家重大基础研究项目(973)：具有纳米修饰的心血管植入器件(2009CB930004)；国家自然科学基金：构建生物相容性良好的镍钛合金血管支架表面若干关键问题的探索(30870623)。

In vitro corrosion behavior of nano-multilayered TiN/Ti coated NiTi alloy

Shao An-liang1,2, Cheng Yan2,3, Xi Ting-fei1,2,3, Zhou Yi3, Zhou Liang1, Wan Zi-yi3   

  1. 1School of Information & Engineering, Wenzhou Medical College, Wenzhou  325035, Zhejiang Province, China
    2Biomedical Engineering Research Center, Shenzhen Institution of Peking University, Shenzhen  518057, Guangdong Province, China
    3Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing  100871, China
  • Received:2010-11-06 Revised:2010-12-29 Online:2011-01-15 Published:2011-01-15
  • Contact: Cheng Yan, Doctor, Associate researcher, Biomedical Engineering Research Center, Shenzhen Institution of Peking University, Shenzhen 518057, Guangdong Province, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China chengyan@pku.edu.cn Correspondence to: Xi Ting-fei, Professor, School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China; Biomedical Engineering Research Center, Shenzhen Institution of Peking University, Shenzhen 518057, Guangdong Province, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China xitingfei@pku.edu.cn
  • About author:Shao An-liang★, Studying for master’s degree, School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China; Biomedical Engineering Research Center, Shenzhen Institution of Peking University, Shenzhen 518057, Guangdong Province, China shaoanliang1984@hotmail.com
  • Supported by:

    the National Key Basic Research Program of China (973 Project), No. 2009CB930004*; the National Natural Science Foundation of China, No.30870623*

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被引次数

11

摘要：

背景：拥有超弹性、形状记忆效应及良好抗疲劳性能的镍钛合金成为封堵器支架核心部分的最佳选择，但镍钛合金含50%的镍元素，其生物相容性仍有争议。
目的：通过体外浸泡实验和电化学实验测试用于治疗先天性心脏病的封堵器镍钛合金多弧离子镀改性前后的抗腐蚀性能。
方法：利用多弧离子镀在镍钛合金表面形成具有纳米梯度的TiN/Ti多层薄膜，通过镍钛合金在PBS中静态浸泡1个月，检测镍离子浓度；采用开路电位-时间曲线和极化曲线观察镀膜前后镍钛合金抗腐蚀性能。
结果与结论：在PBS静态浸泡中镍钛合金在1个月时释放量达到顶峰，而经过多弧离子镀改性后的镍钛合金没有镍离子的释放。开路电位-时间曲线和极化曲线表明改性后的镍钛合金的抗腐蚀性得到了很大提高。

关键词: 纳米涂层, TiN/Ti, 镍钛合金, 腐蚀, 镀膜

Abstract:

BACKGROUND: A nickel-titanium alloy with super-elastic, shape memory effect and good fatigue resistance has become the optimal choice for the core component of occluder stent, but the nickel-titanium alloy containing 50% nickel has a controversial biocompatibility.
OBJECTIVE: To study anti-corrosion property of occluder nickel-titanium alloy before and after multi-arc ion plating by static immersion in vitro and electrochemical methods.
METHODS: Nano-gradient TiN/Ti multilayered films had been fabricated on nickel-titanium alloy by multi-arc ion plating. Nickel ion concentration was investigated by static immersion in PBS for one month. The anti-corrosion property of nickel-titanium alloy before and after surface modification was measured by open circuit potential-time curve and polarization curve.
RESULTS AND CONCLUSION: Nickel-titanium alloy had been released and reached the maximum values during one-month immersion period, while no nickel ion was found released from the TiN/Ti multilayered coated NiTi alloy. Open circuit potential-time curves and polarization curves show that the corrosion resistance of nickel-titanium alloy has been greatly improved after modification.

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