中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (3): 413-416.doi: 10.3969/j.issn.1673-8225.2011.03.008

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

钛质外科网和纳米仿生骨在颈椎前路减压融合中的应用

杨朝垒，王利民，刘屹林，谭宏宇，王卫东   

  1. 郑州大学第一附属医院骨科，河南省郑州市  450052
  • 收稿日期:2010-08-14 修回日期:2010-10-15 出版日期:2011-01-15 发布日期:2011-01-15
  • 通讯作者: 王利民，硕士，教授，硕士生导师，郑州大学第一附属医院骨科，河南省郑州市 450052 gu2ke@yahoo.com.cn
  • 作者简介:杨朝垒★，男，1984年生，河南省平顶山市人，汉族，郑州大学第一附属医院在读硕士，主要从事骨关节、脊柱疾患方面的研究。 chauly2003@163.com
  • 基金资助:

    国家科技支撑计划课题----活性纳米复合生物材料制品手术示范与临床应用(2007BAE13B00 )。

A comparison between titanium surgical mesh and bionic nano-bone in anterior cervical decompression and fusion

Yang Chao-lei, Wang Li-min, Liu Yi-lin, Tan Hong-yu, Wang Wei-dong   

  1. Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou   450052, Henan Province, China
  • Received:2010-08-14 Revised:2010-10-15 Online:2011-01-15 Published:2011-01-15
  • Contact: Wang Li-min, Master, Professor, Master’s supervisor, Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China gu2ke@yahoo.com.cn
  • About author:Yang Chao-lei★, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China chauly2003@163.com
  • Supported by:

    the National Science & Technology Pillar Program of China, No. 2007BAE13B00*

PDF

381

被引次数

5

摘要：

背景：纳米羟基磷灰石/聚酰胺作为新型植骨材料，应用于颈椎前路减压融合中，不仅可以减少患者取骨带来的并发症，而且具有稳定的植骨融合率。
目的：比较钛网和纳米羟基磷灰石/聚酰胺应用于颈椎前路减压融合治疗脊髓型颈椎病的临床效果。
方法：对确诊的48例脊髓型颈椎病患者行颈前路椎体次全切减压融合钛板内固定。其中26例行钛网植骨，22例行纳米羟基磷灰石/聚酰胺仿生骨植骨，采用JOA评分法评价神经功能的恢复，测量cobb角评价融合节段曲度。
结果与结论：48例患者均获得随访，随访时间6~14个月。置入后3个月JOA评分较置入前明显改善，两组对比JOA评分差异无显著性意义；置入后3，6个月钛网组及仿生骨组融合节段cobb角相对于置入后即刻变化差异有显著性意义，两组对比差异无显著性意义；置入后3个月钛网组2例患者出现钛网沉降，融合节段椎间高度丢失。结果表明纳米羟基磷灰石/聚酰胺仿生骨作为颈椎前路融合植骨材料，融合率高，可以有效保持颈椎生理曲度及椎间高度，长期效果有待进一步观察。

关键词: 颈椎病, 钛质外科网, 纳米羟基磷灰石/聚酰胺, 前路植骨融合, 生物相容性

Abstract:

BACKGROUND: Nano-hydroxyapatite/polyamide as a new bone graft material is used in anterior cervical decompression and fusion, it not only reduces the complications after bone removal, and exhibits a stable graft fusion rate.
OBJECTIVE: To study clinical effect of titanium surgical mesh versus nano-hydroxyapatite and polyamide composite (n-HA/PA66) in anterior cervical decompression and fusion for treatment of cervical sondylotic myelopathy.
METHODS: A total of 48 cases of cervical spondylotic myelopathy were treated with anterior cervical subtotal corpectomy and fusion, titanium locking plates fixation, 26 with titanium surgical mesh, 22 with n-HA/PA66. The JOA grading system was done to evaluate neural functional restoration, and Cobb’s angle was measured to evaluate the change of cervical curvature. 
RESULTS AND CONCLUSION: All 48 patients were operated successfully and followed up for 6-14 months. The JOA grading scores were greatly improved in both groups at 3 months postoperation compared with before operation, without significant differences between two groups; at 3 and 6 months postoperation, the Cobb’s angle of all patients had significant differences compared with immediately after operation, without significant differences between two groups; 2 cases were evidenced subsidence of titanium surgical mesh and loss of vertebral height after three months of operation. N-HA/PA66 bionic bone as a graft of anterior cervical fusion has good fusion rate, and could effectively maintain the biological alignment and cervical intervertebral height. The long-term effects depend on further follow-up.

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