中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (23): 5897-5905.doi: 10.12307/2026.346

• 组织构建综述 tissue construction review •    下一篇

线粒体自噬障碍介导肌肉萎缩：来自果蝇模型的启示

李子敬1，陈旭武2，欧阳昕烨3，王茂源4，5，6   

  1. 赣南医科大学，1基础医学院，2康复学院，3第一临床医学院，江西省赣州市   341000；4赣南医科大学第一附属医院，江西省赣州市   341000；  5赣州市智能康复技术创新中心，江西省赣州市   341000；6赣州市康复医学重点实验室，江西省赣州市   341000
  • 收稿日期:2025-05-26 接受日期:2025-08-29 出版日期:2026-08-18 发布日期:2025-12-30
  • 通讯作者: 王茂源，医学博士，教授，主任医师，硕士研究生导师，赣南医科大学第一附属医院，江西省赣州市 341000；赣州市智能康复技术创新中心，江西省赣州市 341000；赣州市康复医学重点实验室，江西省赣州市 341000
  • 作者简介:李子敬，男，2002年生，湖南省岳阳市人，汉族，赣南医科大学在读硕士，主要从事肌肉骨骼系统疾病相关研究。
  • 基金资助:
    赣州市科技局重大项目(2023LNS37155)，项目负责人：王茂源；国家自然科学基金项目(82060420)，项目负责人：王茂源

Mitophagy impairment mediated muscular atrophy: insights from the Drosophila model

Li Zijing1, Chen Xuwu2, Ouyang Xinye3, Wang Maoyuan4, 5, 6   

  1. 1School of Basic Medical Sciences, 2School of Rehabilitation, 3The First School of Clinical Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; 4First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; 5Ganzhou Intelligent Rehabilitation Technological Innovation Center, Ganzhou 341000, Jiangxi Province, China; 6Ganzhou Key Laboratory of Rehabilitation Medicine, Ganzhou 341000, Jiangxi Province, China
  • Received:2025-05-26 Accepted:2025-08-29 Online:2026-08-18 Published:2025-12-30
  • Contact: Wang Maoyuan, MD, Professor, Chief physician, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; Ganzhou Intelligent Rehabilitation Technological Innovation Center, Ganzhou 341000, Jiangxi Province, China; Ganzhou Key Laboratory of Rehabilitation Medicine, Ganzhou 341000, Jiangxi Province, China
  • About author:Li Zijing, MS candidate, School of Basic Medical Sciences, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
  • Supported by:
    Major Project of Ganzhou Science and Technology Bureau, No. 2023LNS37155 (to WMY); National Natural Science Foundation of China, No. 82060420 (to WMY)

PDF

27

摘要：



文题释义：
线粒体自噬：是一种通过特异性清除衰老或受损线粒体，以维持线粒体功能完整和细胞稳态的选择性自噬。
肌肉萎缩：是一种与疾病、衰老和遗传因素相关的肌肉质量和功能进行性下降的病理过程。

背景：肌肉萎缩是一种以肌肉质量和功能进行性下降为特征的病理过程，严重影响患者的生活质量。近年来，线粒体自噬作为维持细胞内稳态的重要线粒体质量控制机制，在肌肉萎缩中的作用备受关注。果蝇作为一种经典的模式生物，因其肌肉的功能结构保守、遗传操作简便等特点，成为研究肌肉萎缩与线粒体自噬机制之间联系的重要工具。
目的：综述线粒体自噬功能障碍在肌肉萎缩中的分子机制，总结相关果蝇模型在该领域的研究进展，以期为肌肉萎缩的病理机制研究和治疗策略的开发提供新的思路与方向。
方法：应用计算机检索PubMed数据库和中国知网，检索关键词为“skeletal muscle，muscle regenerate，denervation muscle atrophy，muscle atrophy，sarcopenia，drosophila，drosophila melanogaster，mitophagy，mitochondrial dysfunction”和“肌肉萎缩，骨骼肌，肌肉再生，肌少症，失神经肌萎缩，果蝇，线粒体自噬，线粒体功能障碍”，结合文献追溯法查找部分文献。检索时限为2001年1月至2025年2月，经过筛选后纳入68篇文献进行综述分析。
结果与结论：果蝇模型的研究表明线粒体自噬在肌肉萎缩的发展中扮演着关键角色，线粒体自噬功能障碍会导致受损的线粒体积聚在肌细胞内，进而引发氧化应激、能量代谢紊乱等，诱导肌细胞凋亡，加剧肌肉萎缩。此外，果蝇模型在筛选潜在治疗靶点和寻找干预策略方面展现出巨大优势，为肌肉萎缩的机制研究和治疗策略的开发提供新途径。通过总结果蝇模型的研究成果，强调了通过调控线粒体自噬机制来治疗肌肉萎缩的策略，突出了果蝇模型在线粒体自噬与肌肉萎缩的分子机制研究中具备的独特优势，未来研究应结合转化医学、高通量分子筛选技术和多组学方法进一步探索线粒体自噬与肌肉萎缩的未知分子机制和治疗新靶点。

https://orcid.org/0000-0003-1952-101X (王茂源)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 肌肉萎缩, 线粒体自噬, 果蝇, 分子机制, 病理机制, 干预策略, 综述

Abstract: BACKGROUND: Muscular atrophy is a pathological process characterized by the progressive decline in muscle mass and function, which severely affects patients’ quality of life. In recent years, the role of mitophagy, as an important mitochondrial quality control mechanism for maintaining intracellular homeostasis, has attracted significant attention in the context of muscle atrophy. Drosophila, as a classical model organism, has become a crucial tool for studying the connection between muscle atrophy and mitophagy mechanism due to its conserved muscle functional structure and straightforward genetic manipulation.
OBJECTIVE: To review the molecular mechanism of mitophagy dysfunction in muscular atrophy and to summarize the research progress of relevant Drosophila models in this field, with the aim of providing new insights and directions for the study of the pathological mechanism and the development of therapeutic strategies for muscular atrophy.
METHODS: PubMed and China National Knowledge Infrastructure databases were screened, using the keywords “skeletal muscle, muscle regenerate, denervation muscle atrophy, muscle atrophy, sarcopenia, drosophila, drosophila melanogaster, mitophagy, mitochondrial dysfunction” in English and Chinese respectively, with literature tracing methods. The search covered the period from January 2001 to February 2025. After screening, 68 articles were included for review and analysis.
RESULTS AND CONCLUSION: The studies on the Drosophila model indicate that mitophagy plays a pivotal role in the development of muscular atrophy. Mitophagy dysfunction leads to the accumulation of damaged mitochondria within muscle cells, subsequently triggers oxidative stress, energy metabolism disorders and etc., induces apoptosis, and exacerbates muscular atrophy. Furthermore, the Drosophila model exhibits significant advantages in screening potential therapeutic targets and identifying intervention strategies, which provides a new way to study the mechanism of muscle atrophy and develop therapeutic strategies in muscle atrophy. To summarize the research outcomes of the Drosophila model, the strategy of regulating mitophagy is emphasized to treat muscle atrophy; the unique advantages of the Drosophila model is highlighted in the study of the molecular mechanism of mitophagy and muscular atrophy. Future research should integrate translational medicine, high-throughput molecular screening technologies, and multi-omics approaches to further explore the unknown molecular mechanisms and novel therapeutic targets of mitophagy and muscle atrophy.

Key words: muscle atrophy, mitophagy, Drosophila, molecular mechanism, pathological mechanism, intervention strategy, review

中图分类号: