中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (36): 5859-5866.doi: 10.12307/2021.355
• 骨与关节综述 bone and joint review • 上一篇 下一篇
李树源1,陈雷雷2,黄林峰1,赵赫然1,吴素雯1,蒋元康1
收稿日期:
2021-02-19
修回日期:
2021-02-22
接受日期:
2021-04-15
出版日期:
2021-12-28
发布日期:
2021-09-18
通讯作者:
陈雷雷,博士,副主任医师,广州中医药大学第三附属医院,广东省广州市 510378
作者简介:
李树源,男,1991年生,山西省汾阳市人,汉族,广州中医药大学在读博士,主要从事中西医结合治疗股骨头坏死、大段骨缺损修复方面的研究。
基金资助:
Li Shuyuan1, Chen Leilei2, Huang Linfeng1, Zhao Heran1, Wu Suwen1, Jiang Yuankang1
Received:
2021-02-19
Revised:
2021-02-22
Accepted:
2021-04-15
Online:
2021-12-28
Published:
2021-09-18
Contact:
Chen Leilei, MD, Associate chief physician, Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510378, Guangdong Province, China
About author:
Li Shuyuan, Doctoral candidate, Third School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Supported by:
摘要:
文题释义:
关节置换:是治疗晚期关节疾病的一种安全有效的手段,也是发展最成功的骨科手术之一。该手术通过重建关节活动功能,减轻关节疼痛等临床症状,提高患者的生活质量。结果与结论:对这些文献进行归纳和分析后发现:①髋、膝关节假体周围感染目前没有明确的诊断和治疗标准;②当前的诊断标准对髋、膝关节假体周围感染诊断的敏感性和特异性仍然较低,需要开发更准确、更简单、更快速的诊断方法;③Ⅱ期翻修仍然是髋、膝关节假体周围感染治疗的金标准,具有适应证广、感染根除率高的优势;④近年来,针对抑制和破坏细菌生物膜的生物治疗正逐渐成为一种新兴的治疗方法,但多处于基础研究,临床应用还不普遍,其远期疗效和安全性仍有待进一步验证。
https://orcid.org/0000-0003-1405-0765 (李树源)
中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程
中图分类号:
李树源, 陈雷雷, 黄林峰, 赵赫然, 吴素雯, 蒋元康. 髋膝关节假体周围感染[J]. 中国组织工程研究, 2021, 25(36): 5859-5866.
Li Shuyuan, Chen Leilei, Huang Linfeng, Zhao Heran, Wu Suwen, Jiang Yuankang. Periprosthetic joint infection of hip and knee[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(36): 5859-5866.
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1.4 质量评估 通过上述计算机检索与手工检索,共检索到890篇文献。按入选标准进行人工筛选,排除与主题相关性差、重复及陈旧的文献,最终纳入97篇文献。纳入研究的文献包括研究原著、综述、临床试验、荟萃分析、病例报告等,文献检索流程见图1。
1.5 数据的提取 研究文献由相互独立的3人提取并通过小组多次讨论解决分歧,信息记录侧重髋膝关节置换术后PJI诊断和治疗的研究进展。
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文题释义:
关节置换:是治疗晚期关节疾病的一种安全有效的手段,也是发展最成功的骨科手术之一。该手术通过重建关节活动功能,减轻关节疼痛等临床症状,提高患者的生活质量。假体周围感染的细菌的流行病学因国家而异。美国罗斯曼研究所和德国汉堡赫利奥斯医院数据显示,美国最常见的感染菌是耐甲氧西林和甲氧西林敏感的金黄色葡萄球菌,以及耐甲氧西林和甲氧西林敏感的表皮葡萄球菌。欧洲凝固酶阴性葡萄球菌的感染率最高,其次是金黄色葡萄球菌、链球菌和肠球菌。翻修手术带来巨大的经济负担。美国住院患者样本数据库最新预测,预计到2030年,美国每年用于治疗髋膝关节PJI的费用估计为18.5亿美元,其中全髋关节置换 PJI为7.5亿美元,全膝关节置换 PJI为11亿美元。
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