中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9329-9332.

• 骨组织构建 • 上一篇    下一篇

2型糖尿病男性骨代谢生化指标与骨密度的变化

陈陵霞，苗懿德，刘杰，魏雅楠，郏蓉，宝辉，褚琳   

  1. 北京大学人民医院老年科，北京市  100044
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 作者简介:陈陵霞☆，女，1972年生，重庆市人，汉族，2001年北京大学医学部毕业，博士，副主任医师，副教授，主要从事骨质疏松症及2型糖尿病并发症方面的研究。 chenlingxia@ medmail.com.cn
  • 基金资助:

    北京大学人民医院研究与发展基金交叉课题(RDI2008-02)，课题名称：多学科联合进行骨质疏松研究。

Changes of bone metabolic biochemical markers and bone mineral density in male patients with type 2 diabetes

Chen Ling-xia, Miao Yi-de, Liu Jie, Wei Ya-nan, Jia Rong, Bao Hui, Chu Lin   

  1. Department of Geriatrics, Peking University People’s Hospital, Beijing  100044, China
  • Online:2010-12-10 Published:2010-12-10
  • About author:Chen Ling-xia☆, Doctor, Associate chief physician, Associate professor, Department of Geriatrics, Peking University People’s Hospital, Beijing 100044, China chenlingxia@medmail.com.cn
  • Supported by:

    Intercrossing Subject of Peking University People’s Hospital Research and Development, No.RDI2008-02*

PDF

496

被引次数

12

摘要：

背景：2型糖尿病患者发生骨质疏松症的概率较高，但其发生发展机制尚不明确。
目的：了解男性2型糖尿病患者骨代谢特点及骨密度的变化。
方法：纳入2008-09/2010-01北京大学人民医院老年科住院及门诊男性2型糖尿病患者97例，均符合WHO 1999年糖尿病诊断标准，并排除血肌酐升高及糖尿病肾病患者；同时纳入同期的非糖尿病男性76例。空腹采血测定血骨保护素、抗酒石酸酸性磷酸酶、骨钙素、骨碱性磷酸酶、Ⅰ型胶原C末端水平。同时收集相关临床资料及生化指标，应用Hologic双能X射线骨密度仪测定骨密度。
结果与结论：男性糖尿病患者各部位骨密度与非糖尿病者差异无显著性意义(P > 0.05)。男性糖尿病患者骨保护素及Ⅰ型胶原C末端较非糖尿病者显著升高(P < 0.05)，而骨钙素、骨碱性磷酸酶、抗酒石酸酸性磷酸酶水平与非糖尿病者差异无显著性意义(P > 0.05)。提示骨保护素及I型胶原C末端在男性2型糖尿病患者骨质疏松症的发生中有一定的作用。

关键词: 糖尿病, 骨代谢, 骨密度, 男性, 骨质疏松

Abstract:

BACKGROUND: Patients with type 2 diabetes are in high risk with osteoporosis. But the pathogenesis is not clear.
OBJECTIVE: To investigate the characteristics of bone metabolism and the changes of bone mineral density in male patients with type 2 diabetes.
METHODS: Totally 97 male patients with type 2 diabetes and 76 male patients without diabetes were included in this study. All the subjects were included from the clinic and the ward of the Department of Geriatrics in Peking University Hospital from September 2008 to January 2010. The diagnostic standards accorded with diabetes formulated by WHO (1999). Patients with high serum creatinine level or with diabetic nephropathy were excluded. The level of serum osteoprotegerin (OPG), bone gla-protein (BGP), tartrate-resistant acid phosphatase (TRAP), bone alkaline phosphatase (BAP) and C-telopeptide of type-I collagen (CTX) were measured by ELISA. Clinical data and some biochemical items were collected simultaneously. The bone mineral density was determined by dual X-ray bone densitometer. 
RESULTS AND CONCLUSION: Compared with none diabetes group, the male patients with type 2 diabetes had no difference in bone mineral density of different regions (P > 0.05). But the OPG level and CTX level increased significantly in diabetes group   (P < 0.05). BGP, BAP and TRAP had no obvious changes (P > 0.05). It indicated that BGP and CTX play roles in the pathogenesis of diabetic osteoporosis.

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