中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (13): 2121-2126.doi: 10.3969/j.issn.2095-4344.1687

• 干细胞综述 stem cell review • 上一篇    下一篇

间充质干细胞源外泌体在肺部疾病中的应用与作用

钟玉兰，淦 鑫   

  1. 南昌大学第一附属医院呼吸内科，江西省南昌市 330006
  • 修回日期:2019-01-11 出版日期:2019-05-08 发布日期:2019-05-08
  • 通讯作者: 淦鑫，博士，主任医师，南昌大学第一附属医院呼吸内科，江西省南昌市 330006
  • 作者简介:钟玉兰，女，1992年生，江西省安远县人，汉族，南昌大学在读硕士，医师，主要从事慢性阻塞性肺疾病及干细胞的研究。
  • 基金资助:

    国家自然科学基金(81660009，81260004)，项目负责人：淦鑫；江西省自然科学基金(20161ACB20012)，项目负责人：淦鑫

Mesenchymal stem cell-derived exosomes in lung diseases

Zhong Yulan, Gan Xin   

  1. Department of Respiratory Medicine, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • Revised:2019-01-11 Online:2019-05-08 Published:2019-05-08
  • Contact: Gan Xin, MD, Chief physician, Department of Respiratory Medicine, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • About author:Zhong Yulan, Master candidate, Physician, Department of Respiratory Medicine, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81660009 and 81260004 (both to GX); the Natural Science Foundation of Jiangxi Province, No. 20161ACB20012 (to GX)

PDF

118

摘要：

文章快速阅读：

文题释义：
细胞外囊泡：是由多种细胞分泌的纳米级囊泡，包括直径为40-100 nm的外泌体和直径100-1 000 nm的微泡及50-4 000 nm的凋亡小体，它们是细胞间通讯的介质，被绝大多数细胞释放到细胞外微环境中并携带脂质、蛋白质、mRNA、miRNA或非编码RNA等，来自特定细胞类型的细胞外囊泡，特别是间充质干细胞外囊泡，有望成为治疗新策略。
外泌体：是一种细胞外脂质囊泡，通常直径为40-100 nm，密度为1.10-1.18 g/mL，表达特异性膜蛋白，如CD9、CD63和CD8，外泌体最独特的功能是与靶向受体细胞的特异性相互作用，这可能是细胞间通讯的基础，各种细胞衍生的外泌体参与重要的生理和病理过程。

 

摘要
背景：间充质干细胞的功能机制已成为近年来的研究热点，越来越多的证据支持间充质干细胞以旁分泌的形式介导免疫抑制以及促再生活动等。间充质干细胞来源外泌体具有与间充质干细胞类似的功能，例如修复组织损伤、抑制炎症反应和调节免疫系统。近年来对间充质干细胞来源外泌体在肺部疾病中的研究也日渐增长。
目的：综述间充质干细胞源外泌体在肺部疾病中的研究进展。
方法：以“间充质干细胞，外泌体，肺”为中文检索词，以“MSCs，exosome，lung，pulmonary，pulmonic”为英文检索词，在PubMed数据库、CNKI和万方等数据库中检索2001年9月至2018年9月发表的有关间充质干细胞源外泌体与肺部疾病的文章，排除重复及不相关文章。
结果与结论：外泌体是间充质干细胞的旁分泌效应物，并且具有其亲本细胞在一系列不同疾病模型中的重要活性，包括向多谱系分化、分泌细胞因子、促进细胞增殖和免疫调节；间充质干细胞源外泌体含有调节受体细胞功能的miRNA、蛋白质、脂质等，其作为肺部疾病的无细胞治疗剂具有若干优点，有望成为治疗肺部疾病的新策略。


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程
ORCID: 0000-0002-2459-7150(钟玉兰)

关键词: 间充质干细胞, 外泌体, 肺动脉高压, 肺癌, 支气管肺发育不良, 急性肺损伤, 急性呼吸窘迫综合征, 国家自然科学基金

Abstract:

BACKGROUND: The functional mechanisms of mesenchymal stem cells have become a research hotspot in recent years. Increasing evidence indicates the role of mesenchymal stem cells in mediating immunosuppression and promoting regeneration in a paracrine manner. Mesenchymal stem cell-derived exosomes have similar functions as mesenchymal stem cells, such as repairing tissue damage, inhibiting inflammatory responses, and modulating the immune system. Recent research on mesenchymal stem cell-derived exosomes in lung diseases has also been increasing.
OBJECTIVE: To review the research progress of mesenchymal stem cell-derived exosomes in lung diseases.
METHODS: “Mesenchymal stem cells, exosomes, lungs” were used as Chinese search terms, and “MSCs, exosome, lung, pulmonary, pulmonic” were used as English search terms. PubMed, CNKI, and WanFang databases were searched for articles concerning mesenchymal stem cell-derived exosomes and lung diseases published from September 2001 to September 2018. Duplicate and irrelevant articles were excluded.
RESULTS AND CONCLUSION: Exosomes are paracrine effectors of mesenchymal stem cells and have important activities of their parental cells in a series of different disease models, including differentiation into multiple lineages, secretion of cytokines, promotion of cell proliferation and immune regulation. Exosomes derived from mesenchymal stem cells contain miRNAs, proteins, lipids, etc., which regulate the function of receptor cells. The use of mesenchymal stem cell-derived exosomes as a cell-free therapeutic agent for lung diseases offers several advantages, which is expected to be a new therapeutic protocol for lung diseases.

Key words: Mesenchymal Stem Cells, Exosomes, Lung Diseases, Tissue Engineering

中图分类号: