中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (10): 1596-1603.doi: 10.3969/j.issn.2095-4344.2017.10.020

• 生物材料综述 biomaterial review • 上一篇    下一篇

周围神经损伤后瓦勒氏变性及神经导管的研究与进展

苌  彪,全  琦,孙  逊,刘若西,王  玉,卢世璧,彭  江   

  1. 解放军总医院骨科研究所,北京市再生医学重点实验室,全军战创伤重点实验室,北京市100853
  • 收稿日期:2016-11-26 出版日期:2017-04-08 发布日期:2017-05-08
  • 通讯作者: 彭江,博士,研究员,解放军总医骨科研究所,北京市再生医学重点实验室,全军战创伤重点实验室,北京市 100853
  • 作者简介:苌彪,男,1990年生,北京市人,汉族,解放军医学院在读硕士,主要从事周围神经再生研究。
  • 基金资助:

    国家自然科学基金项目(51073024;51273021);973重点项目(2014CB542201;2012CB518106);军队“十三五”医学专项(BWS13C029)

Wallerian degeneration after peripheral nerve injury: research advance in nerve conduits

Chang Biao, Quan Qi, Sun Xun, Liu Ruo-xi, Wang Yu, Lu Shi-bi, Peng Jiang   

  1. Orthopedic Institute of General Hospital of Chinese PLA, Beijing Key Lab of Regenerative Medicine, Key Laboratory of Trauma & War Injuries of Chinese PLA, Beijing 100853, China
  • Received:2016-11-26 Online:2017-04-08 Published:2017-05-08
  • Contact: Peng Jiang, M.D., Researcher, Orthopedic Institute of General Hospital of Chinese PLA, Beijing Key Lab of Regenerative Medicine, Key Laboratory of Trauma & War Injuries of Chinese PLA, Beijing 100853, China
  • About author:Chang Biao, Studying for master’s degree, Orthopedic Institute of General Hospital of Chinese PLA, Beijing Key Lab of Regenerative Medicine, Key Laboratory of Trauma & War Injuries of Chinese PLA, Beijing 100853, China
  • Supported by:

    the National Natural Science Foundation of China, No. 51073024, 51273021; the National Basic Research Program of China (973 Program), No. 2014CB542201, 2012CB518106; the Special Project of the “Thirteenth Five-year Plan” for Medicine Development of Chinese PLA, No. BWS13C029

摘要:

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文题释义:
瓦勒氏变性
:骨科名词,由于各种创伤、牵拉、缺血、高低温、电击等原因,直接使神经纤维受损中断,周围神经损伤后远段发生的轴突坏死、髓鞘分解消失和神经鞘膜增生等一系列蜕变和细胞吞噬过程,称为瓦勒氏变性Wallerian Degeneration(Waller,Augustus Volney,1816年生,英国伦敦内科医师)。
烟酰胺腺嘌呤二核苷酸(简称:辅酶Ⅰ,英语:Nicotinamide adenine dinucleotide,NAD+):作为氧化还原过程中的必需辅酶和NAD+依赖性二磷酸腺苷(ADP)核糖基转移酶(主要为ADP核糖基转移酶或聚ADP核糖基聚合酶(PARP)、环ADP核糖聚合酶(cADP合酶)、Ⅲ型组蛋白去乙酰化酶(Sirtuins))唯一能利用的物质,参与细胞物质代谢、能量合成、细胞DNA修复等多种生理活动。


背景:如何促进损伤的周围神经再生尤其是大段神经缺损是一个棘手的临床难题,亟待解决。
目的:回顾近些年瓦勒氏变性机制及神经导管的发展。
方法:检索PubMed 数据库,检索词为“peripheral nerve regeneration;Wallerian degeneration;nerve guidance conduits。根据纳入排除标准,选出有关瓦勒氏变性分子机制及神经修复的文献74篇进行探讨。
结果与结论:研究发现大鼠SARM1和同源物果蝇dSARM在促进瓦勒氏变性中起关键作用,推断烟酰胺腺嘌呤单核苷酸/烟酰胺腺嘌呤二核苷酸比例的改变可能对SARM1的激活起一定的作用。对于延迟瓦勒氏变性到底是好是坏,目前还存在争议。周围神经损伤后短时间内抑制瓦勒氏变性并积极促进再生达到周围神经损伤及时修复是未来努力的方向。

ORCID: 0000-0002-5349-9197(苌彪)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 生物材料, 材料相容性, 周围神经再生, 瓦勒氏变性, 神经导管, 国家自然科学基金

Abstract:

BACKGROUND: How to promote the regeneration after peripheral nerve injury, especially after large defects, is a difficulty to be solved.
OBJECTIVE: To review the mechanism of Wallerian degeneration and the development of nerve conduits.
METHODS: PubMed database was searched for the literatures addressing the modular mechanism of Wallerian degeneration and nerve repair using the English keywords “peripheral nerve regeneration, Wallerian degeneration, nerve guidance conduits”. A total of 74 eligible literatures were included based on the exclusion criteria.
RESULTS AND CONCLUSION: Rat SARM1 and fruit fly dSARM have been found to be highly implicated in Wallerian degeneration, indicating that the changes of nicotinamide adenine nucleotide/nicotinamide adenine dinucleotide may be related to the activated SARM1. Whether delaying Wallerian degeneration is good or bad is still in dispute. The future study should focus on the early inhibition of Wallerian degeneration and promotion of neuroregeneration following peripheral nerve injury.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Peripheral Nerves, Myelin Sheath, Cytokines, Tissue Engineering

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