中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (26): 6868-6872.doi: 10.12307/2026.209

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

体外环境下C-Root BP材料根尖封闭性及抗力强度

周丽静，王  双，向谨姣，王会超，柴雪姣    

  1. 石家庄市第二医院口腔科，河北省石家庄市   050000
  • 接受日期:2025-09-10 出版日期:2026-09-18 发布日期:2026-03-12
  • 通讯作者: 周丽静，硕士，副主任医师，石家庄市第二医院口腔科，河北省石家庄市 050000
  • 作者简介:周丽静，女，1986年生，河北省石家庄市人，汉族，硕士，副主任医师，主要从事牙体牙髓及牙周、黏膜临床相关疾病方面的研究。
  • 基金资助:
    河北省2025年度医学研究课题(20251097)，项目负责人：周丽静

Apical sealing and resistance strength of C-Root BP material in in vitro environment

Zhou Lijing, Wang Shuang, Xiang Jinjiao, Wang Huichao, Chai Xuejiao   

  1. Department of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang 050000, Hebei Province, China
  • Accepted:2025-09-10 Online:2026-09-18 Published:2026-03-12
  • Contact: Zhou Lijing, MS, Associate chief physician, Department of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang 050000, Hebei Province, China
  • About author:Zhou Lijing, MS, Associate chief physician, Department of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang 050000, Hebei Province, China
  • Supported by:
    Hebei Province 2025 Medical Research Project, No. 20251097 (to ZLJ)

PDF

15

摘要：

文题释义：

C-Root BP材料：是一种预混合的生物陶瓷根管修复材料，核心成分包括硅酸锶、硅酸钙、氧化钽等无机化合物。C-Root BP材料具备出色的生物相容性、封闭性及骨诱导能力，适用于根管治疗中的根尖封闭与修复，是现代根尖区修复的重要选择之一。 
根尖封闭性：是牙科领域评估根管治疗材料或根尖修复材料性能的核心指标，指材料在根尖孔区域形成物理与生物屏障，阻止口腔内细菌、毒素、组织液及外界物质通过根尖孔渗透至根尖周组织的能力。

背景：近年来，生物陶瓷材料因具有良好的生物相容性和封闭性能逐渐成为根尖倒充填的首选材料，其中生物陶瓷材料C-Root BP、iRoot BP Plus均具有良好的生物相容性和封闭性能。
目的：对比体外环境下C-Root BP与iRoot BP Plus材料的根尖封闭性能及抗力强度。
方法：于2022年6月至2024年6月期间，收集石家庄市第二医院口腔科因正畸或牙周病新鲜拔除的单根离体牙56颗，随机分4组处理：iRoot BP Plus组(n=16)、C-Root BP组(n=16)根管预备和消毒后分别采用iRoot BP Plus、C-Root BP材料进行根尖倒充填，阳性对照组(n=16)根管预备和消毒后使用蒸馏水进行根尖倒充填，阴性对照组(n=8)仅行根管预备和消毒(不进行根尖倒充填处理)，采用染料渗透法检测根尖封闭性；制作根管细菌渗漏体外模型，评价细菌微渗漏发生情况；采用薄片推出实验检测填充材料与牙本质之间的粘连强度，并在显微镜下观察断裂形式。
结果与结论：①染料染色7 d后，阳性对照组染料渗透长度大于iRoot BP Plus组、C-Root BP组(P < 0.05)，iRoot BP Plus组和C-Root BP组染料渗透长度比较差异无显著性意义(P > 0.05)；②经过90 d培养，阳性对照组细菌微渗漏发生率高于iRoot BP Plus组、C-Root BP组(P < 0.05)，iRoot BP Plus组和C-Root BP组细菌微渗漏发生率比较差异无显著性意义(P > 0.05)；③C-Root BP组填充材料与牙本质之间的粘连强度大于iRoot BP Plus组(P < 0.05)，两组断裂面断裂形式比较差异无显著性意义(P > 0.05)；④结果表明，采用C-Root BP和iRoot BP Plus材料进行根尖倒充填可产生相似的根尖封闭效果，并且断裂形式也基本一致，但C-Root BP材料具有良好的粘连强度。
https://orcid.org/0009-0009-8036-9599 (周丽静) 

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: C-Root BP, iRoot BP Plus, 根尖倒充填, 根尖封闭性, 抗力强度, 细菌, 根管治疗, 生物材料

Abstract: BACKGROUND: In recent years, bioceramic materials have become the preferred materials for retrograde apical filling due to their excellent biocompatibility and sealing properties. The bioceramic materials C-Root BP and iRoot BP Plus both exhibit excellent biocompatibility and sealing properties.
OBJECTIVE: To compare the apical sealing performance and resistance strength of C-Root BP and iRoot BP Plus materials in vitro. 
METHODS: From June 2022 to June 2024, 56 freshly extracted single detached teeth at the Department of Stomatology, Shijiazhuang Second Hospital due to orthodontics or periodontal disease were collected and randomly divided into four groups. The iRoot BP Plus group (n=16) and C-Root BP group (n=16) were respectively treated with iRoot BP Plus and C-Root BP materials for root tip filling. The positive control group (n=16) was treated with distilled water for root tip filling, while the negative control group (n=8) was not treated with root tip filling and only underwent routine root canal preparation and disinfection. Dye penetration method was used to detect the apical sealing. A root canal bacterial leakage model was made in vitro, and bacterial microleakage was evaluated. The adhesion strength between the filling material and dentin was measured by wafer extrusion test, and the fracture form was observed under a microscope. 
RESULTS AND CONCLUSION: (1) After 7 days of dye staining, the dye penetration length of the positive control group was greater than that of the iRoot BP Plus group and C-Root BP group (P < 0.05). There was no significant difference in dye penetration length between the iRoot BP Plus group and the C-Root BP group (P > 0.05). (2) After 90 days of cultivation, the incidence of bacterial microleakage in the positive control group was higher than that in the iRoot BP Plus group and C-Root BP group (P < 0.05), while there was no significant difference in the incidence of bacterial microleakage between the iRoot BP Plus group and C-Root BP group (P > 0.05). (3) The adhesion strength between the filling material and dentin in the C-Root BP group was greater than that in the iRoot BP Plus group (P < 0.05), and there was no significant difference in the fracture surface pattern between the two groups (P > 0.05). (4) These findings indicate that the use of C-Root BP and iRoot BP Plus materials for root tip filling can produce similar root tip sealing effects, and the fracture mode is also basically the same. However, C-Root BP material has good adhesion strength.


Key words: C-Root BP, iRoot BP Plus, retrograde root tip filling, apical sealing, resistance strength, bacteria, root canal treatment, biomaterial

中图分类号: