中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (17): 4529-4541.doi: 10.12307/2026.139

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

铜死亡研究进展可视化分析：全球视野下的热点与前沿

李瑞颖1，夏  翃2   

  1. 1首都医科大学第四临床医学院，北京市   100176；2首都医科大学生物医学工程学院，北京市   100069

  • 收稿日期:2025-04-24 接受日期:2025-08-10 出版日期:2026-06-18 发布日期:2025-12-05
  • 通讯作者: 夏翃，博士，副教授，首都医科大学生物医学工程学院，北京市 100069
  • 作者简介:李瑞颖，女，2004年生，北京市人，汉族，首都医科大学第四临床医学院在读，主要从事眼视光医学研究。
  • 基金资助:
    2024年全国高等院校计算机基础教育研究会课题(2024-AFCEC-105)，项目负责人：夏翃；2024年首都医科大学科研创新项目(XSKY2024160)，项目负责人：夏翃

Visual analysis of cuproptosis research: global landscape of hotspots and frontiers

Li Ruiying1, Xia Hong2   

  1. 1Forth Clinical School, Capital Medical University, Beijing 100176, China; 2School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
  • Received:2025-04-24 Accepted:2025-08-10 Online:2026-06-18 Published:2025-12-05
  • Contact: Xia Hong, PhD, Associate professor, School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
  • About author:Li Ruiying, Forth Clinical School, Capital Medical University, Beijing 100176, China
  • Supported by:
    the National Research Association of Computer Basic Education in Colleges and Universities of China, No. 2024-AFCEC-105 (to XH); the Scientific Research and Innovation Project of Capital Medical University, No. XSKY2024160 (to XH)

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摘要：


文题释义：
可视化分析：将复杂的数据信息转换成易于理解的图像，以便研究者能直观地了解某一研究领域的模式、趋势、关联性等信息。
铜死亡：一种新发现的细胞死亡形式，由细胞内铜离子过载触发，在疾病特别是癌症的理解中具有重要意义，并为新的治疗策略提供了潜在方向。

背景：铜死亡作为一种新兴的细胞死亡方式，近年来受到广泛关注。然而，目前对于铜死亡的全球研究态势，尤其是在不同国家和学术群体中的研究重点与发展趋势尚缺乏系统性的认识。为了更全面地把握铜死亡领域的研究进展，亟需进行多数据库、多角度的文献计量分析。
目的：通过文献计量学方法系统分析铜死亡领域的研究现状、热点及发展趋势。
方法：采用文献计量学方法，结合CiteSpace和VOSviewer可视化分析工具，分别对国际权威的Web of Science核心合集数据库与中国知网数据库(CNKI)中2022-2024年间的1 378篇铜死亡相关文献进行分析，包括年发文量、科研合作网络、关键词共现聚类与热点变动特征以及高被引文献。通过对比分析这两个数据库的数据，旨在揭示全球视野下铜死亡研究的整体态势。
结果与结论：铜死亡研究呈现快速增长趋势，中国发文量居首，以上海交通大学、中南大学等为核心机构。研究主题集中于铜死亡机制、肿瘤治疗应用(化学动力学疗法)及与铁死亡的交叉调控。关键词突现分析表明“免疫微环境”“肿瘤治疗”是研究热点。机器学习基因预测模型和单细胞测序技术正在推动精准医学发展。英文研究多集中于机制探索和技术应用，其研究方法、技术路线和热点方向对正处于快速发展期的国内铜死亡研究具有重要的借鉴意义。尤其是在肿瘤治疗等重大疾病领域开展跨学科合作和多中心临床转化研究，有望为包括中国人群在内的恶性肿瘤等重大疾病诊疗提供更具针对性和有效性的新策略。

https://orcid.org/0009-0004-6111-3161 (李瑞颖) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 铜死亡, 文献计量学, 可视化分析, CiteSpace, VOSviewer, 研究进展, 肿瘤治疗, 免疫浸润

Abstract: BACKGROUND: Cuproptosis, as an emerging form of cell death, has garnered widespread attention in recent years. However, there is a lack of systematic understanding of the global research dynamics of cuproptosis, especially the research priorities and trends in different countries and academic communities. A multi-database, multi-faceted bibliometric analysis is urgently needed to provide a more comprehensive understanding of the research progress in the field of cuproptosis.
OBJECTIVE: To systematically analyze the research status, hotspots, and development trends in the field of cuproptosis using bibliometric methods.
METHODS: Using bibliometric methods combined with CiteSpace and VOSviewer visualization and analysis tools, we retrieved and analyzed 1 378 cuproptosis-related literature published from 2022 to 2024 in the international authoritative Web of Science core collection database and the China Knowledge Network database (CNKI). This analysis included annual publication volume, research cooperation network, keyword co-occurrence, clustering and hotspot change characteristics, and highly cited literature. By comparing and analyzing the data from these two databases, we aim to reveal the overall landscape of cuproptosis research from a global perspective.
RESULTS AND CONCLUSION: Cuproptosis research has shown a rapid growth trend, with China leading in the number of publications, where institutions such as Shanghai Jiao Tong University and Central South University serve as the core institutions. The research theme focuses on the mechanism of cuproptosis, tumor therapeutic application (chemokinetic therapy) and cross-regulation with ferroptosis. The keyword emergence analysis showed that "immune microenvironment" and "tumor therapy" are the research hotspots. Machine-learning gene prediction models and single-cell sequencing technologies are driving the development of precision medicine. Most of the English studies focus on the exploration of mechanisms and application of technologies. Their research methods, technical routes and hot directions are of great significance to the cuproptosis research in China, which is in the rapid development period. In particular, interdisciplinary cooperation and multi-center clinical translational research in the field of tumor treatment and other major diseases are expected to provide more targeted and effective new strategies for the diagnosis and treatment of malignant tumors and other major diseases, including the Chinese population.
Funding: the National Research Association of Computer Basic Education in Colleges and Universities of China, No. 2024-AFCEC-105 (to XH); the Scientific Research and Innovation Project of Capital Medical University, No. XSKY2024160 (to XH)

Key words: cuproptosis, bibliometrics, visual analysis, CiteSpace, VOSviewer, research progress, tumor therapy, immune infiltration

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