中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (6): 1580-1591.doi: 10.12307/2026.594

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

衰老在骨质疏松领域研究现状及趋势的文献可视化分析

张海文1，张  贤2，许太川1，李  超2   

  1. 1南京中医药大学，江苏省无锡市  210023；2南京中医药大学附属无锡医院，江苏省无锡市  214000


  • 收稿日期:2024-12-06 接受日期:2025-02-20 出版日期:2026-02-28 发布日期:2025-07-19
  • 通讯作者: 张贤，主任中医师，博士生导师，南京中医药大学附属无锡医院，江苏省无锡市 214000
  • 作者简介:张海文，男，2002年生，贵州省安顺市人，汉族，南京中医药大学在读硕士，主要从事中医骨伤科学(骨科退行性疾病)方面的研究。
  • 基金资助:
    国家中医药管理局国家中医优势专科建设项目(国中医药医政函[2024]90号)，项目负责人：张贤；江苏省基础研究计划资助项目(BK20231147)，项目负责人：张贤；江苏省中医药科技发展计划项目(MS2021044)，项目负责人：张贤

Bibliometric and visual analysis of the research status and trends of senescence in osteoporosis

Zhang Haiwen1, Zhang Xian2, Xu Taichuan1, Li Chao2   

  1. 1Nanjing University of Chinese Medicine, Wuxi 210023, Jiangsu Province, China; 2Affiliated Wuxi Hospital of Nanjing University of Chinese Medicine, Wuxi 214000, Jiangsu Province, China
  • Received:2024-12-06 Accepted:2025-02-20 Online:2026-02-28 Published:2025-07-19
  • Contact: Zhang Xian, Chief physician, Doctoral supervisor, Affiliated Wuxi Hospital of Nanjing University of Chinese Medicine, Wuxi 214000, Jiangsu Province, China
  • About author:Zhang Haiwen, MS candidate, Nanjing University of Chinese Medicine, Wuxi 210023, Jiangsu Province, China
  • Supported by:
    National TCM Advantageous Specialty Construction Project of National Administration of Traditional Chinese Medicine, No. [2024]90 (to ZX); Jiangsu Province Basic Research Program, No. BK20231147 (to ZX); Jiangsu Province TCM Science and Technology Development Program Project, No. MS2021044 (to ZX)

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摘要：


文题释义：
衰老：指细胞周期停止与细胞停止分裂的状态，可发生在生物体的任何阶段，包括胚胎发生、生长和发育、组织重塑以及伤口愈合过程中。随着年龄增长，衰老细胞堆积，机体会出现器官功能下降和年龄相关疾病。
文献计量学：以文献及相关特征为研究对象，采用统计与数学工具分析文献的分布规律、引用关系、研究热点及发展趋势，广泛应用于科学评价和知识图谱构建，用定量方法对文献的生产、传播和利用进行研究的一门学科。

背景：细胞衰老引起机体生理性衰退的老化过程，与骨质疏松密切相关。随着衰老研究的发展，靶向清除衰老细胞研究取得显著进展，基于此的衰老细胞疗法治疗骨质疏松症日益受到关注。当前衰老与骨质疏松的关联研究呈现多学科交叉特征，但现有综述多基于单一数据库(如PubMed)且缺乏中英文文献的系统对比分析。因此，整合多数据库资源，系统揭示衰老在骨质疏松研究领域的研究现状及热点趋势，具有重要的学术价值。
目的：总结近20年来衰老在骨质疏松领域研究的发展历程、研究现状、热点和未来趋势，以期为今后相关研究提供参考。
方法：在中国知网、万方知识平台、维普网与Web of Science核心数据库中检索衰老与骨质疏松相关性的研究文献，检索时间跨度为2004-08-01/2024-09-24，使用文献管理软件NoteExpress 4.0进行数据清洗，CiteSpace 6.3R1(Advanced)、Excel(2024)进行文献分析。
结果与结论：自2004年以来，衰老与骨质疏松相关性的研究呈现显著增长态势。文献计量分析显示(截至2024年9月)，英文文献发表1 275篇，中文文献发表151篇，其中以中国和美国的发文数量最多。从发文机构来看，梅奥医学中心居于榜首，其次是上海交通大学、加州大学系统。从核心作者来看，发文和被引最多的作者是Sundeep Khosla与Joshua Nicholas Farr，中文文献中裴凌鹏和惠伯棣最值得关注。通过排除关键词中“衰老”与“骨质疏松”及同义词后，发现细胞衰老、衰老相关分泌表型、信号通路、靶向衰老细胞清除治疗是当下的研究热点和理论前沿。
https://orcid.org/0009-0004-0354-9979(张海文)；https://orcid.org/0000-0002-2400-698X(张贤)

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 骨质疏松, 衰老, CiteSpace, 细胞衰老, 衰老相关分泌表型, 热点

Abstract: BACKGROUND: Cellular senescence, which triggers the aging process of physiological decline in the body, is closely related to osteoporosis. With the development of aging research, significant progress has been made in the study of targeted clearance of senescent cells. Accordingly, senolytic cell therapy for osteoporosis based on this has attracted increasing attention. Current research on the association between aging and osteoporosis shows the characteristic of multidisciplinary intersection. However, existing reviews are mostly based on a single database (such as PubMed) and lack a systematic comparative analysis of Chinese and English literature. Therefore, it is of great academic value to integrate resources from multiple databases and systematically reveal the research status and hot trends of aging in the field of osteoporosis research.
OBJECTIVE: To summarize the development, current status, hotspots, and future trends of research on aging in the field of osteoporosis over the past 20 years, so as to provide references for future related research.
METHODS: We searched for research literature on the correlation between aging and osteoporosis in CNKI, WanFang, VIP and Web of Science Core Database. The search time span was from August 1, 2004 to September 24, 2024. Then, we used NoteExpress 4.0 for data cleaning and CiteSpace 6.3R1 (Advanced) and Excel (2024) for literature analysis.
RESULTS AND CONCLUSION: Since 2004, research on the correlation between aging and osteoporosis has shown a significant growth trend. Bibliometric analysis shows that (as of September 2024), and 1 275 English documents and 151 Chinese documents have been published, with the highest number of publications in China and the United States. In terms of publishing institutions, the Mayo Clinic ranked first, followed by Shanghai Jiao Tong University and the University of California system. As for core authors, Sundeep Khosla and Joshua Nicholas Farr were the authors with the most publications and citations, while Pei Lingpeng and Hui Bodi were the most worthy of attention in Chinese literature. After the keywords “aging” and “osteoporosis” and their synonyms were excluded, it was found that cellular senescence, senescence-associated secretory phenotype, signaling pathways, and targeted senolytic cell clearance therapy haven been the current research hotspots and theoretical frontiers.

Key words: osteoporosis, senescence, CiteSpace;, cellular senescence, senescence-associated secretory phenotype, hotspots

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