中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (6): 1305-1311.doi: 10.12307/2025.317

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

不同运动强度与骨关节炎发病风险的效应分析

马浩宇,乔鸿超,郝茜茜,史冬博   

  1. 太原理工大学体育学院,山西省晋中市  030600
  • 收稿日期:2024-03-05 接受日期:2024-04-19 出版日期:2025-02-28 发布日期:2024-06-24
  • 通讯作者: 史冬博,教授,研究生导师,太原理工大学体育学院,山西省晋中市 030600
  • 作者简介:马浩宇,男,1998年生,山西省太原市人,汉族,太原理工大学在读硕士,主要从事体育运动与健康促进方面的研究。

Causal effects of different exercise intensities on the risk of osteoarthritis 

Ma Haoyu, Qiao Hongchao, Hao Qianqian, Shi Dongbo   

  1. College of Physical Education, Taiyuan University of Technology, Jinzhong 030600, Shanxi Province, China
  • Received:2024-03-05 Accepted:2024-04-19 Online:2025-02-28 Published:2024-06-24
  • Contact: Shi Dongbo, Professor, Master’s supervisor, College of Physical Education, Taiyuan University of Technology, Jinzhong 030600, Shanxi Province, China
  • About author:Ma Haoyu, Master candidate, College of Physical Education, Taiyuan University of Technology, Jinzhong 030600, Shanxi Province, China

摘要:




文题释义:
骨关节炎:是由年龄增长、肥胖、劳损、创伤、先天性畸形、关节畸形等因素引起的关节软骨退化损伤、关节边缘和软骨下骨反应性增生,属于退行性病变的一种,多见于中老年人,好发于负重关节和活动量较多的关节(如颈椎、腰椎、膝关节、髋关节等)。
孟德尔随机化:是一种用于病因推断的流行病学数据分析方法。在非实验数据中,孟德尔随机化使用遗传变异作为工具变量来估计感兴趣的暴露因素与所关注的结果之间的因果关系。

背景:越来越多的证据表明不同运动强度与骨关节炎风险之间存在关联,但这可能受到混杂和反向因果关系的影响,结论尚未统一。
目的:应用孟德尔随机化探索不同运动强度与骨关节炎的因果关联。
方法:选取与不同运动强度相关联的全基因组关联研究数据,以阈值P < 5×10-8筛选工具变量,采用孟德尔随机化5种分析方法评估暴露与结局风险的因果关系,以逆方差加权法作为主要分析方法。使用选定的工具变量来评估不同运动强度与骨关节炎的因果关联,并进行敏感性分析与反向孟德尔随机化分析。
结果与结论:①逆方差加权法分析结果显示,低强度运动对膝骨关节炎的保护效应显著(OR=0.14,95%CI:0.06-0.32,P < 0.001),久坐行为(例如电视观看)是膝骨关节炎和髋骨关节炎的危险因素(OR=2.24,95%CI:1.74-2.88,P < 0.001;OR=1.34,95%CI:1.01-1.78,P=0.04)。对于骨关节炎与不同运动强度的反向孟德尔随机化分析发现,骨关节炎与低强度运动呈负相关性,与电视观看呈正相关。②分析结果显示,不同运动强度与骨关节炎风险存在双向因果关系。


关键词: 运动强度, 骨关节炎, 孟德尔随机化, 因果关联, 膝骨关节炎, 髋骨关节炎

Abstract:
BACKGROUND:
Increasing evidence supports the association between different exercise intensities and the risk of osteoarthritis, but this may be affected by confounding and reverse causality, and the conclusions have not been unified.
OBJECTIVE: To explore the causal association between different exercise intensities and osteoarthritis using Mendelian randomization method.
METHODS: Data from genome-wide association studies associated with different exercise intensities were selected, and instrumental variables were screened with a threshold of P < 5×10-8. Causal associations between exposure and risk of outcome were assessed using five analysis methods of Mendelian randomization with inverse variance weighting as the primary analysis method. Selected instrumental variables were used to assess causal associations between different exercise intensities and osteoarthritis, and sensitivity analyses with inverse Mendelian randomization were performed.
RESULTS AND CONCLUSION: In the analysis results of the inverse variance weighting method, low-intensity exercise showed a significant protective effect on knee osteoarthritis [odds ratio (OR)=0.14, 95% confidence interval (CI): 0.06-0.32, P < 0.001], while sedentary behavior without exercise intensity, such as watching TV, was confirmed to be a risk factor for knee osteoarthritis and hip osteoarthritis (OR=2.24, 95% CI: 1.74-2.88, P < 0.001; OR=1.34, 95% CI: 1.01-1.78, P=0.04). Through the reverse Mendelian randomization analysis of osteoarthritis to different exercise intensities, it was found that osteoarthritis was negatively correlated with low-intensity exercise and positively correlated with watching TV. The analysis results show that there is a two-way causal relationship between different exercise intensity and osteoarthritis risk.

Key words: exercise intensity, osteoarthritis, Mendelian randomization, causal association, knee osteoarthritis, hip osteoarthritis

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