中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (3): 426-432.doi: 10.12307/2023.982

• 生物材料综述 biomaterial review • 上一篇    下一篇

软组织和硬组织再生过程中的电纺纳米纤维支架

王欣怡1,谢宪瑞2,陈玉杰1,王晓宇1,徐小青1,沈怿弘1,莫秀梅1   

  1. 1上海纳米生物材料与再生医学研究中心,东华大学,生物与医学工程学院,上海市  201600;2滨州医学院,药学院,“方剂效应与临床评价”国家中医药管理局重点研究室,山东省滨州市  256600
  • 收稿日期:2022-10-09 接受日期:2023-02-17 出版日期:2024-01-28 发布日期:2023-07-10
  • 通讯作者: 莫秀梅,博士,教授,硕士生导师,博士生导师,上海纳米生物材料与再生医学研究中心,东华大学,生物与医学工程学院,上海市 201600
  • 作者简介:王欣怡,女,2000年生,江苏省淮安市人,汉族,东华大学在读硕士,主要从事静电纺丝应用于组织再生的研究。 谢宪瑞,滨州医学院,药学院,“方剂效应与临床评价”国家中医药管理局重点研究室,山东省滨州市 256600

Electrospun nanofiber scaffolds for soft and hard tissue regeneration

Wang Xinyi1, Xie Xianrui2, Chen Yujie1, Wang Xiaoyu1, Xu Xiaoqing1, Shen Yihong1, Mo Xiumei1   

  1. 1School of Biological and Medical Engineering, Donghua University, Shanghai Nanobiomaterials and Regenerative Medicine Research Center, Shanghai 201600, China; 2Key Laboratory of “Prescription Effect and Clinical Evaluation” State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Binzhou 256600, Shandong Province, China
  • Received:2022-10-09 Accepted:2023-02-17 Online:2024-01-28 Published:2023-07-10
  • Contact: Mo Xiumei, MD, Professor, Master’s supervisor, Doctoral supervisor, School of Biological and Medical Engineering, Donghua University, Shanghai Nanobiomaterials and Regenerative Medicine Research Center, Shanghai 201600, China
  • About author:Wang Xinyi, Master candidate, School of Biological and Medical Engineering, Donghua University, Shanghai Nanobiomaterials and Regenerative Medicine Research Center, Shanghai 201600, China Xie Xianrui, Key Laboratory of “Prescription Effect and Clinical Evaluation” State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Binzhou 256600, Shandong Province, China

摘要:


文题释义:

电纺纳米纤维支架:是用静电纺丝法制备的由纳米纤维丝交织而成的组织再生用支架材料,为膜状、管状及块状等,用于皮肤、血管、神经、肌腱、骨和软骨等的组织再生。
组织再生:是机体对由某种原因引起死亡的细胞进行补偿与恢复的过程。组织不断地进行更新,称为生理性再生。


背景:目前,静电纺丝纳米纤维是天然细胞外基质的仿生材料,其包含互连孔隙的三维网络,已成功用作各种组织再生的支架,但目前仍面临着如何将生物材料扩展成三维结构以再现组织微环境的生理、化学以及机械性能的挑战。

目的:总结归纳静电纺丝的工艺、原理,探讨由此生产的静电纺丝纳米纤维在皮肤、血管、神经、骨骼、软骨和肌腱/韧带等组织再生中的应用。
方法:以“静电纺丝、电纺纳米纤维、电纺纳米纤维支架、组织再生”为中文检索词,“Electrospinning,electrospun nanofibers,electrospun nanofiber scaffolds,tissue regeneration”为英文检索词,检索Google学术、PubMed和中国知网数据库,最终纳入88篇文献进行综述分析。

结果与结论:①静电纺丝纳米纤维是天然纤维状细胞外基质的仿生材料,并包含互连孔隙的三维网络,在各种组织再生的支架领域中应用较多。②多篇文献阐述了电纺纳米支架应用于皮肤、血管、神经、骨骼、软骨和肌腱/韧带组织再生的巨大潜力,为其最终应用于临床疾病治疗,或转化为实际产品进入市场提供了坚实的理论基础。③但目前的研究成果多是基于体外的细胞实验研究成果,能否最终应用于人体尚需临床验证。④目前国内外已有多种用于各种临床需求的电纺产品商业化,表明用于软组织和硬组织再生的电纺纳米纤维支架研究领域具有重大的研究价值和应用潜力。

https://orcid.org/0000-0001-9238-6171(莫秀梅)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料口腔生物材料纳米材料缓释材料材料相容性组织工程

关键词: 静电纺丝, 纳米纤维, 电纺纳米纤维支架, 组织工程, 组织再生, 软组织再生, 硬组织再生, 综述

Abstract: BACKGROUND: Currently, electrospun nanofibers, which are biomimetic materials of natural extracellular matrix and contain a three-dimensional network of interconnected pores, have been successfully used as scaffolds for various tissue regeneration, but are still faced with the challenge of extending the biomaterials into three-dimensional structures to reproduce the physiological, chemical as well as mechanical properties of the tissue microenvironment.
OBJECTIVE: To summarize the process and principles of electrostatic spinning and to explore the applications of the resulting electrospun nanofibers in tissue regeneration of skin, blood vessels, nerves, bone, cartilage and tendons/ligaments. 
METHODS: With “electrospinning, electrospun nanofibers, electrospun nanofiber scaffolds, tissue regeneration” as the Chinese and English search terms, Google Academic Database, PubMed, and CNKI were searched, and finally 88 articles were included for review.
RESULTS AND CONCLUSION: (1) The electrospun nanofibers are a natural fibrous extracellular matrix mimetic material and contain a three-dimensional network of interconnected pores that have been successfully used as scaffolds for a variety of tissue regeneration applications. (2) Several papers have described the great potential of electrospun nanofiber scaffolds applied to the regeneration of skin, blood vessels, nerves, bones, cartilage and tendons/ligaments, providing a solid theoretical basis for its final application in clinical disease treatment, or for its transformation into practical products to enter the market. (3) However, the current research results are mostly based on cell experimental research results in vitro, and whether it can be finally applied to human body still needs clinical verification. (4) At present, many kinds of electrospun products for various clinical needs have been commercialized in and outside China, indicating that the research field of electrospun nanofiber scaffolds for soft and hard tissue regeneration has great research value and application potential.

Key words: electrostatic spinning, nanofibre, electrospun nanofiber scaffold, tissue engineering, tissue regeneration, soft tissue regeneration, hard tissue regeneration, review

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