中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (4): 617-625.doi: 10.12307/2022.101
• 生物材料综述 biomaterial review • 上一篇 下一篇
张 通1,蔡金池1,袁志发1,赵海燕2,韩兴文2,王文己2
收稿日期:
2020-08-07
修回日期:
2020-08-11
接受日期:
2020-09-19
出版日期:
2022-02-08
发布日期:
2021-12-06
通讯作者:
王文己,主任医师,博士,博士生导师,兰州大学第一医院骨科,甘肃省兰州市 730000
作者简介:
张通,男,1994年生,陕西省汉中市人,蒙古族,兰州大学第一临床医学院在读硕士,医师,主要从事骨科相关生物材料研究。
基金资助:
Zhang Tong1, Cai Jinchi1, Yuan Zhifa1, Zhao Haiyan2, Han Xingwen2, Wang Wenji2
Received:
2020-08-07
Revised:
2020-08-11
Accepted:
2020-09-19
Online:
2022-02-08
Published:
2021-12-06
Contact:
Wang Wenji, Chief physician, MD, Doctoral supervisor, Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
About author:
Zhang Tong, Master candidate, Physician, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China
Supported by:
摘要:
文题释义:
基于透明质酸的复合水凝胶:透明质酸是一种天然多糖,也是人体中常见的一种糖胺聚糖,因其生物相容性、可降解性等生物性能被制作为水凝胶广泛应用于组织工程中,尤其通过不同方法与生物因子、天然材料、合成材料、3D打印技术、多肽、机械刺激联合制成复合水凝胶,在软骨修复方面有着巨大的前景。
骨关节炎的软骨损伤:骨关节炎是一种退行性病变,软骨组织的慢性炎症通过免疫反应等机制破坏软骨的蛋白多糖及Ⅱ型胶原合成,软骨组织的自我修复因其缺乏血管而十分困难,最终导致软骨损伤。
背景:透明质酸是一种天然多糖,也是人体中常见的一种糖胺聚糖,在眼睛和关节中的浓度最高,因其生物相容性、可降解性和低免疫原性而被制成水凝胶广泛应用于组织工程中。
目的:介绍各类透明质酸复合水凝胶的特点以及在骨关节炎软骨损伤修复中的应用。
方法:以“透明质酸,水凝胶,软骨修复,骨关节炎”为中文关键词检索CNKI、万方等数据库,以“hyaluronic acid;hydrogel;Cartilage repair;osteoarthritis”为英文关键词检索PubMed、Web of science等数据库,检索1995年1月至2020年7月发表的文献,筛选后进一步分析总结。
结果与结论:透明质酸水凝胶优异的生物性能使其在骨关节炎软骨修复中得到了广泛研究,尤其是通过联合生物因子、天然材料、合成材料、3D打印技术、多肽、机械刺激等改善了透明质酸水凝胶的性能,推进了其在软骨组织工程中的应用。在未来随着化学、材料、物理、生物等多学科的综合发展,更加深入地了解透明质酸水凝胶降解的机制及探索骨关节炎的软骨损伤机制,有望设计出可以高效、无任何不良反应、更加适用软骨组织工程的透明质酸复合水凝胶。
https://orcid.org/0000-0002-9325-0230 (张通)
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程
中图分类号:
张 通, 蔡金池, 袁志发, 赵海燕, 韩兴文, 王文己. 基于透明质酸的复合水凝胶修复骨关节炎软骨损伤:应用与机制[J]. 中国组织工程研究, 2022, 26(4): 617-625.
Zhang Tong, Cai Jinchi, Yuan Zhifa, Zhao Haiyan, Han Xingwen, Wang Wenji. Hyaluronic acid-based composite hydrogel in cartilage injury caused by osteoarthritis: application and mechanism[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(4): 617-625.
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文题释义:
基于透明质酸的复合水凝胶:透明质酸是一种天然多糖,也是人体中常见的一种糖胺聚糖,因其生物相容性、可降解性等生物性能被制作为水凝胶广泛应用于组织工程中,尤其通过不同方法与生物因子、天然材料、合成材料、3D打印技术、多肽、机械刺激联合制成复合水凝胶,在软骨修复方面有着巨大的前景。
骨关节炎的软骨损伤:骨关节炎是一种退行性病变,软骨组织的慢性炎症通过免疫反应等机制破坏软骨的蛋白多糖及Ⅱ型胶原合成,软骨组织的自我修复因其缺乏血管而十分困难,最终导致软骨损伤。
透明质酸水凝胶凭借着其优异的生物相容性、生物降解性和低免疫原性而被选择作为骨关节炎软骨损伤修复中的生物支架,但仍具有机械性能差、细胞黏附性低等不足。该文通过检索国内外数据库,归纳总结国内外学者通过将透明质酸水凝胶联合生物因子、天然材料、合成材料、3D打印技术、多肽、机械刺激等制成复合水凝胶,改善了透明质酸水凝胶的性能,进一步推进了在软骨组织工程中的应用。
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