中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (33): 5373-5378.doi: 10.3969/j.issn.2095-4344.0672

• 干细胞综述 stem cell review • 上一篇    下一篇

间充质干细胞治疗成骨不全:是直接分化为功能细胞还是旁分泌作用

汪子涵,刘 义,鞠明艳,李 光   

  1. 天津医科大学基础医学院遗传学系,天津市 300070
  • 修回日期:2018-08-31 出版日期:2018-11-28 发布日期:2018-11-28
  • 通讯作者: 李光,教授,博士生导师,天津医科大学基础医学院遗传学系,天津市 300070
  • 作者简介:汪子涵,女,1997年生,天津市人,汉族,天津医科大学基础医学专业本科在读,主要从事干细胞治疗成骨不全相关研究。
  • 基金资助:

    国家重点研发计划(2017YFC1001904);天津市科技支撑计划(16YFZCSY00900)

Mesenchymal stem cells for treating osteogenesis imperfecta: directly differentiating into functional cells or functioning via paracrine mechanism?

Wang Zi-han, Liu Yi, Ju Ming-yan, Li Guang   

  1. Department of Genetics, School of Basic Medicine, Tianjin Medical University, Tianjin 300070, China
  • Revised:2018-08-31 Online:2018-11-28 Published:2018-11-28
  • Contact: Li Guang, Professor, Doctoral supervisor, Department of Genetics, School of Basic Medicine, Tianjin Medical University, Tianjin 300070, China
  • About author:Wang Zi-han, Department of Genetics, School of Basic Medicine, Tianjin Medical University, Tianjin 300070, China
  • Supported by:

    the National Key R&D Program of China, No. 2017YFC1001904; Tianjin City Science and Technology Support Program, No. 16YFZCSY00900

摘要:

文章快速阅读:

文题释义:
间充质干细胞:
是一类从脂肪或骨髓等组织中分离出来的、具有贴壁能力、呈集落样生长的成纤维样多能干细胞,在体内外可向成骨、成脂、成软骨等方向诱导分化,具有自我更新和免疫调节能力。
成骨不全:是一种全身性结缔组织疾病,约90%患者由Ⅰ型胶原合成及分泌异常引起,表现为常染色体显性遗传,主要累及骨骼系统,使骨骼脆性增加,反复骨折,骨关节进行性畸形,同时也可累及眼、耳、皮肤、牙齿等,出现蓝巩膜、耳聋、皮肤异常以及牙本质发育不全等临床症状。

 

摘要
背景:
传统的药物治疗和手术治疗成骨不全有诸多局限性,近年来越来越多的科学家尝试用间充质干细胞移植治疗成骨不全。
目的:旨在通过间充质干细胞治疗成骨不全进展的总结,指导动物实验,以促进其临床应用。
方法:由第一作者应用计算机检索PubMed 2000年1月至2018年6月相关文献。在标题、摘要、关键词中以“osteogenesis imperfecta,stem cells,mesenchymal stem cells,stem cells therapy,stem cells transplantation”为检索词进行检索。选择与间充质干细胞治疗成骨不全相关的文章,同一领域选择近期发表的文章。
结果与结论:间充质干细胞可以通过直接分化为功能细胞和旁分泌作用治疗成骨不全带来的骨缺损,其低免疫原性和免疫调节作用可保证移植治疗的安全性。间充质干细胞可以从根本上治疗成骨不全,并且能避免药物治疗的不良反应,具有广阔应用前景。尽管目前尚缺乏系统的间充质干细胞治疗成骨不全的有效性和安全性标准,但间充质干细胞移植治疗可以规避传统药物和手术治疗的局限性,期待更多相关研究使之趋于成熟和完善,推动间充质干细胞治疗成骨不全向临床应用转化,真正使患者受益。


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID:
0000-0002-3298-5444(李光);0000-0001-8193-7054(汪子涵)

关键词: 成骨不全, 间充质干细胞, 干细胞移植, 骨髓间充质干细胞

Abstract:

BACKGROUND: Some limitations involving drug therapies and surgical treatment exist in the traditional treatment of osteogenesis imperfecta. In recent years, a growing number of scientists attempt to treat osteogenesis imperfecta by mesenchymal stem cells transplantation.
OBJECTIVE: To summarize the mesenchymal stem cell treatment of osteogenesis imperfecta to guide relevant animal experiments, thereby promoting its clinical application.
METHODS: A computer-based online search of PubMed between January 2000 and June 2018 was performed to search related articles with the keywords of “osteogenesis imperfecta, stem cells, mesenchymal stem cells, stem cells therapy, stem cells transplantation” in English. Literatures regarding mesenchymal stem cells for treatment of osteogenesis imperfecta were selected; in the same field, the articles published lately in authoritative journals were preferred.
RESULTS AND CONCLUSION: Mesenchymal stem cells can directly differentiate into functional cells or exert paracrine effect to repair bone defects caused by osteogenesis imperfecta. The low immunogenicity and immunomodulatory capacity of mesenchymal stem cells ensure the transplantation safety in the treatment of osteogenesis imperfecta. Mesenchymal stem cells can fundamentally treat osteogenesis imperfecta, and do not produce adverse reactions that are unavoidable in the drug treatment, which have broad application prospects. Although there are currently no systematic criteria for the efficacy and safety of mesenchymal stem cells in the treatment of osteogenesis imperfecta, mesenchymal stem cell transplantation can circumvent the limitations of conventional drugs and surgical treatment. Further studies are expected to improve the treatment of osteogenesis imperfecta using mesenchymal stem cells and promote its clinical applications, as cell transplantation indeed benefits the patients. 


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Osteogenesis Imperfecta, Mesenchymal Stem Cell Transplantation, Tissue Engineering

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