中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (30): 4901-4907.doi: 10.3969/j.issn.2095-4344.2017.30.024

• 生物材料综述 biomaterial review • 上一篇    下一篇

神经导管支架修复外周神经损伤的研究与现状

陈  勇1,2,范  林1,付  贞3,熊  艳1,王彦峰1,叶啟发1,3,秦  伟2
  

  1. 1武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,移植医学技术湖北省重点实验室,湖北省武汉市  430071;2青海大学附属医院腹部腔镜外科,青海省西宁市  810001;3中南大学湘雅三医院,卫生部移植医学工程技术研究中心,湖南省长沙市  410013
  • 收稿日期:2017-05-19 出版日期:2017-10-28 发布日期:2017-11-07
  • 通讯作者: 叶啟发,博士,主任医师,武汉大学中南医院肝胆疾病研究院,湖北省武汉市
  • 作者简介:陈勇,男,1988年生,湖北省襄阳市人,汉族,青海大学在读硕士,主要从事普通外科研究。
  • 基金资助:
    国家自然科学基金重点项目(21334005)

Repairing peripheral nerve injury with nerve conduits

Chen Yong1, 2, Fan Lin1, Fu Zhen3, Xiong Yan1, Wang Yan-feng1, Ye Qi-fa1, 3, Qin Wei2
  

  1. 1Hubei Key Laboratory of Transplantation Medicine, Center for Transplantation Medicine of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China; 2Department of Laparoscopic Surgery, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China; 3Research Center for Transplantation Medical Engineering Technology, Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
  • Received:2017-05-19 Online:2017-10-28 Published:2017-11-07
  • Contact: Ye Qi-fa, M.D., Chief physician, Hubei Key Laboratory of Transplantation Medicine, Center for Transplantation Medicine of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
  • About author:Chen Yong, Studying for master’s degree, Hubei Key Laboratory of Transplantation Medicine, Center for Transplantation Medicine of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 21334005

摘要:

文章快速阅读:

 

文题释义:
神经导管:也叫神经再生室,20世纪40年代由Weiss 等提出,用以桥接神经断端,20世纪70年代后期开始逐渐使用生物材料神经导管修复周围神经缺损。神经导管是使用自体组织或者天然、人工合成材料经过一定的加工工艺制作而成的具有一定空间、物理性能以及营养支持功能的促进神经再生的通道。
 
背景:近些年来,医学和组织工程学突飞猛进的发展为制作神经导管材料提供了更多选择。
目的:综述神经导管在外周神经损伤中的应用。
方法:由第一作者检索2010至2016年中国知网数据库和PubMed数据库,中文检索词为“神经导管,外周神经”,英文检索词为“nerve conduit,peripheral nerve”。
结果与结论:制作神经导管的材料,主要分生物型和非生物型2大类,其中生物型主要包括肌肉、羊膜、静脉、小肠黏膜下层等;非生物型材料包括壳聚糖、胶原蛋白、丝素蛋白、聚乳酸、聚己内酯、聚苯胺及硅胶管等。目前,部分材料已被批准进入临床阶段。神经导管在修复周围神经损伤的应用中还存在或多或少的问题,比如,修复缺损的长度受限,力学性能和机械性能与神经再生不完全匹配,降解速度与神经再生速度不一致,神经导管的生物相容性欠佳等。

关键词: 生物材料, 材料相容性, 神经导管, 周围神经, 壳聚糖, 神经损伤, 国家自然科学基金

Abstract:

BACKGROUND: In recent years, the rapid development of medical and tissue engineering has provided more choices for making nerve conduit preparation.
OBJECTIVE: To review the application of nerve conduits in the repair of peripheral nerve injury.
METHODS: The first author retrieved the CNKI and PubMed databases to search relevant articles published from 2010 to 2016. The key words were "nerve conduit, peripheral nerve" in Chinese and English, respectively.
RESULTS AND CONCLUSION: The nerve conduit materials are mainly classified into biotype and non-biotype. Biotype materials mainly include muscle, amniotic membrane, vein and small intestinal submucosal layer. The non-biotype materials include chitosan, collagen, silk fibroin, polylactic acid, polycaprolactone, polyaniline and silicone tubes. Some materials currently have been approved to enter the clinical stage. There are more or less problems in the clinical application of nerve conduits in the repair of peripheral nerve injury. For example, the length of a defect that can be repaired is limited; the mechanical properties and mechanical properties are not exactly matched with nerve regeneration; the degradation rate is inconsistent with the rate of nerve regeneration; and poor biocompatibility exists.

Key words: Biocompatible Materials, Peripheral Nerves, Chitosan, Tissue Engineering

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