中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (25): 3687-3692.doi: 10.3969/j.issn.2095-4344.2016.25.006

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

可注射珊瑚人工骨与经皮球囊成型修复股骨头坏死

朱康华1，2，孟志斌1，黄 涛1，谭海涛1，孙 博1，庞学毅1   

  1. 1海南医学院附属医院脊柱骨病外科，海南省海口市  570102；2贵阳中医学院，贵州省贵阳市  550000
  • 收稿日期:2016-04-19 出版日期:2016-06-17 发布日期:2016-06-17
  • 通讯作者: 孟志斌，教授，海南医学院附属医院脊柱骨病外科，海南省海口市 570102
  • 作者简介:朱康华，男，1987年生，河南省平舆县人，汉族，硕士，主要从事脊柱外科，骨组织生物工程材料研究。
  • 基金资助:

    海南省科技厅重点科技项目(ZDXM20120053)

Percutaneous balloon angioplasty combined with injectable coral artificial bone repairs femoral head necrosis

Zhu Kang-hua1, 2, Meng Zhi-bin1, Huang Tao1, Tan Hai-tao1, Sun Bo1, Pang Xue-yi1   

  1. 1Department of Spinal Surgery, Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China; 2Graduate School of Guiyang University of Traditional Chinese Medicine, Guiyang 550000, Guizhou Province, China
  • Received:2016-04-19 Online:2016-06-17 Published:2016-06-17
  • Contact: Meng Zhi-bin, Professor, Department of Spinal Surgery, Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China
  • About author:Zhu Kang-hua, Master, Department of Spinal Surgery, Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China; Graduate School of Guiyang University of Traditional Chinese Medicine, Guiyang 550000, Guizhou Province, China
  • Supported by:

    the Science and Technology Key Project of Hainan Provincial Science and Technology Department, No. ZDXM20120053

PDF

494

摘要：

 文章快速阅读：

 

文题释义：
珊瑚珊瑚羟基磷灰石人工骨：天然珊瑚为一种多孔结构体，其主要成分碳酸钙为无定形结构。利用珊瑚的结构特性，将碳酸钙中的碳酸根换成磷酸根，得到珊瑚羟基磷灰石，基本过程为珊瑚在高温、高压下与磷酸长时间反应，得到珊瑚孔结构保持完好的珊瑚羟基磷灰石，该材料除保持珊瑚的孔结构外，还提高了珊瑚的硬度，而羟基磷灰石是骨组织的主要无机成分，与骨组织的相容性更好。
股骨头坏死治疗：治疗方法分为保守治疗和手术治疗，保守治疗主要是改善循环及止痛等，主要目的是减缓股骨头坏死速度，最终还是需要手术治疗；手术治疗的方法有很多，如髓芯减压、带血管蒂的骨移植等，无论是哪种方法，最终必然导致全髋或半髋置换，除此之外还有一些相关生物治疗的研究，无论哪一种方法都有一定的缺点。

 

摘要
背景：目前治疗股骨头坏死的方法有很多，如髓芯减压、骨移植及关节塑形、关节置换等，每一种方法都有自身的缺点。经皮球囊合并珊瑚人工骨为治疗股骨头坏死提供了一种新的尝试。
目的：观察可注射珊瑚人工骨合并经皮球囊成型修复股骨头坏死的有效性。
方法：将24只杜洛克仔猪随机分为实验组与对照组，均采用液氮冷冻法建立双侧股骨头坏死模型，实验组选择其中一侧行经皮球囊合并含骨髓间充质干细胞的可注射珊瑚人工骨植入治疗，对照组选择一侧行骨水泥填充治疗，另一侧均不做治疗，作为空白对照组。术后2，4，8，16周进行X射线、生物力学与组织学检测。
结果与结论：①X射线结果：术后16周，实验组有大量新骨生成，人工骨与周围边界模糊；对照组未见新生骨生成，材料与周围边界清晰；空白对照组股骨头表面发生塌陷，骨小梁紊乱，被破坏；②生物力学结果：实验组术后不同时间点的生物力学优于对照组、空白对照组(P < 0.05)；③组织学变化：术后16周，实验组珊瑚人工骨周围可见大量骨小梁及骨细胞生成，珊瑚人工骨大部分溶解；对照组骨水泥呈现无规律的状态，未见骨小梁生成；空白对照组塌陷区骨小梁连续性破坏，结构散乱；④结果表明：可注射珊瑚人工骨合并经皮球囊成型修复股骨头坏死，可促进新骨生成。

 

 ORCID: 0000-0001-5569-903X(孟志斌)

关键词: 生物材料, 骨生物材料, 可注射珊瑚人工骨, 经皮球囊后凸成形, 间充质干细胞, 股骨头坏死

Abstract:

BACKGROUND: There are many methods for the treatment of femoral head necrosis, such as core decompression, bone graft, arthroplasty and joint replacement, and each of which has its own shortcomings. So, percutaneous balloon angioplasty combined with coral artificial bone provides a new attempt for the treatment of femoral head necrosis.

 
OBJECTIVE: To observe the effect of percutaneous balloon angioplasty combined with coral artificial bone on femoral head necrosis repair.
METHODS: Twenty-four Duroc piglets were enrolled to establish bilateral femoral head necrosis models by liquid nitrogen freezing method. Then, model piglets were randomly treated with percutaneous balloon angioplasty combined with injectable coral artificial bone (experimental group) or bone cement (control group) on one affected side, and meanwhile, given no treatment on the contralateral side (blank control group). At 2, 4, 8 and 16 weeks after surgery, X-ray examination, biomechanical test and histological detection were conducted.

RESULTS AND CONCLUSION: X-ray showed that at 16 weeks after surgery, numerous new bones could be found in the experimental group and there was a fuzzy boundary between the artificial bone and surrounding tissues; no new bone formed in the control group, and the boundary was clear; in the blank control group, the surface of the femoral head collapsed, and bone trabeculae arranged disorderly, which were seriously destroyed. And in the histological detection at 16 weeks after surgery, there were numerous bone trabecula and osteoblasts around the coral bone in the experimental group, and the coral artificial bone almost dissolved; in the control group, bone cement was in an irregular shape and no bone trabecula formed; in the blank control group, bone trabecula were damaged in the collapsed area, whose structure was in disorder. Additionally, biomechanical changes in the experimental group were significantly better than those in the other two groups at different time points after surgery (P < 0.05). In conclusion, percutaneous balloon angioplasty combined with coral artificial bone can repair femoral head necrosis by promoting new bone formation.

 

 

 

Key words: Femur Head Necrosis, Stem Cells, Tissue Engineering

中图分类号: