中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (46): 8589-8592.doi: 10.3969/j.issn.2095-4344.2012.46.008

• 骨组织构建 bone tissue construction • 上一篇    下一篇

人引导骨再生修复颌骨缺损的组织学观察

陈红亮1，赵承初2，孙 勇2，赵 峰2，钟 科2   

  1. 1泸州医学院口腔医学院，四川省泸州市 646000
    2解放军成都军区机关医院口腔科，四川省成都市 610011
  • 收稿日期:2012-10-15 修回日期:2012-10-20 出版日期:2012-11-11 发布日期:2013-03-16
  • 通讯作者: 孙勇，主任医师，解放军成都军区机关医院口腔科，四川省成都市 610011 chl1976sxl@163.com
  • 作者简介:陈红亮★，泸州医学院口腔医学院在读硕士。 Chl1976sxl@163.com

Guided bone regeneration repairs human mandibular bone defects: Histological observation

Chen Hong-liang1, Zhao Cheng-chu2, Sun Yong2, Zhao Feng2, Zhong Ke2   

  1. 1Stomatological School of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
    2Department of Stomatology, the Hospital Affiliated to Chengdu Military Region, Chengdu 610011, Sichuan Province, China
  • Received:2012-10-15 Revised:2012-10-20 Online:2012-11-11 Published:2013-03-16
  • Contact: Sun Yong, Chief physician, Department of Stomatology, the Hospital Affiliated to Chengdu Military Region, Chengdu 610011, Sichuan Province, China Chl1976sxl@163.com
  • About author:Chen Hong-liang★, Studying for master’s degree, Stomatological School of Luzhou Medical College, Luzhou 646000, Sichuan Province, China

PDF

690

被引次数

7

摘要：

背景：引导骨再生对于成骨的引导及成形效果在基础研究及动物实验中已得到充分肯定，但国内有关人的颌骨骨缺损后引导骨再生中新生骨的组织学观察是一个空白。
目的：应用组织学检查了解人引导骨再生修复颌骨骨缺损的成骨效果。
方法：选取引导骨再生治疗颌骨骨缺损患者19例24个部位，于治疗后6个月行种植术中，中空钻取出术区新生骨，组织学观察，评价成骨效果。
结果与结论：所取新生骨可见不同发育阶段的骨形成。近根尖段骨中主要为板层骨，而冠方新生骨主要为纤维性骨形成，内含类骨组织及软骨性骨，极少板层骨。提示人颌骨骨缺损经引导骨再生后6个月成骨效果肯定，但远期效果还有待进一步观察。

关键词: 引导骨再生, 人, 颌骨, 骨缺损, 成骨效果, 组织学, 种植体, 骨形成, 组织构建

Abstract:

BACKGROUND: Osteogenesis effects of guided bone regeneration have been verified in basic research and animal experiments. However, histological observation of bone regeneration following repair of human mandibular bone defects using guided bone regeneration is not reported in China.
OBJECTIVE: To study the osteogenesis effects of guided bone regeneration on the repair of human mandibular bone defects through histological observation.
METHODS: Twenty-four defects from 19 mandibular bone defect patients were subjected to guided bone regeneration therapy. After 6 months, dental implantation was performed. New bone tissues in the surgical area were taken using a hollow drill for histological observation and osteogenesis evaluation.
RESULTS AND CONCLUSION: Different developmental stages of bone formation were visible in new bone tissues. Lamellar bone tissues were mainly found near the root apex, while fibrous bone tissues containing osteoid tissue and cartilage bone formed at the dental crown. It indicated that there is a certain 6-month osteogenesis effect of guided bone regeneration, but the long-term effect needs further observation.

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