中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (16): 2905-2908.doi: 10.3969/j.issn.1673-8225.2012.16.013

• 药物控释材料 drug delivery materials • 上一篇    下一篇

编织型复合管道支架的制备及载药性能★

张万灵1, 2,陈南梁1, 2,赵炯心3,张秀芳1,王大新4   

  1. 1东华大学纺织学院,上海市  201620;2产业用纺织品教育部工程研究中心,上海市  201620;3东华大学材料学院,上海市  201620;4扬州大学生物医学工程研究所,江苏省扬州市  225009
  • 收稿日期:2011-03-05 修回日期:2011-12-11 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 陈南梁,博士,教授, 东华大学纺织学院,上海市 201620 nlch@ dhu.edu.cn
  • 作者简介:张万灵★,男,1985年生,湖北省枣阳市人,汉族,东华大学在读硕士,主要从事生物医用纺织品研发方面的研究。 zhangwanling521@mail.dhu.edu.cn

Construction of a weaving tubular scaffold and its drug loading property

Zhang Wan-ling1, 2, Chen Nan-liang1, 2, Zhao Jiong-xin3, Zhang Xiu-fang1, Wang Da-xin4   

  1. 1College of Textiles, Donghua University, Shanghai  201620, China; 2Engineering Research Center of Technical Textile, Ministry of Education, Shanghai  201620, China; 3College of Materials Science and Engineering, Donghua University, Shanghai  201620, China; 4Institute of Biomedical Engineering, Yangzhou University, Yangzhou  225009, Jiangsu Province, China
  • Received:2011-03-05 Revised:2011-12-11 Online:2012-04-15 Published:2012-04-15
  • Contact: author: Chen Nan-liang, Doctor, Professor, College of Textiles, Donghua University, Shanghai 201620, China; Engineering Research Center of Technical Textile, Ministry of Education, Shanghai 201620, China nlch@dhu.edu.cn
  • About author:Zhang Wan-ling★, Studying for master’s degree, College of Textiles, Donghua University, Shanghai 201620, China; Engineering Research Center of Technical Textile, Ministry of Education, Shanghai 201620, China zhangwanling521@ mail.dhu.edu.cn

摘要:

背景:金属材料和一般的高分子材料制备的管道支架生物相容性和载药性能很差,可降解高分子材料制备的管道支架具有很好的生物相容性,且双层复合结构有利于提高管道支架的径向支撑力和载药性能。
目的:总结可降解高分子材料编织的双层复合管道支架的制作方法,探讨制作材料以及编织结构对管道支架的载药性能的影响。
方法:用聚对二氧环己酮编织内层管道支架,用聚乙交酯丙交酯编织外层管道支架。以紫杉醇与阿奇霉素为药剂,测试管道支架载药后质量的变化。
结果与结论:聚乙交酯丙交酯编织的单层管道支架的载药率大于聚对二氧环己酮编织的单层管道的载药率,聚乙交酯丙交酯与聚对二氧环己酮复合编织的双层管道支架的载药性能优于单层管道支架。

关键词: 复合管道支架, 可降解, 编织, 聚乙交酯丙交酯, 载药性

Abstract:

BACKGROUND: Tubular scaffolds constructed using metal materials and general polymer materials have poor biocompatibility and drug loading property. Tubular scaffolds constructed using biodegradable polymer materials have good biocompatibility; besides, their double layer structure is good for the improvement of the radial support and drug loading property.
OBJECTIVE: To expound a construction method of a weaving double-layer composite tubular scaffold using biodegradable polymer materials as well as to explore the effects of the manufacturing materials and weaving structure on the drug loading property of the tubular scaffold.
METHODS: The lining tubular scaffold was weaved using poly (p-dioxanone), while the outer tubular scaffold was weaved using poly (glycolide-co-lactide). The change in quality of the tubular scaffold from before to after drug loading was detected using paclitaxel and azithromycin.
RESULTS AND CONCLUSION: The drug loading rate of the single-storey tubular scaffold weaved using poly (glycolide-co- lactide) was higher than that of the single-storey tubular scaffold weaved using poly (p-dioxanone). The drug loading rate of the two-storey composite tubular scaffold weaved using poly (glycolide-co-lactide) and poly (p-dioxanone) was superior to that of the single-storey tubular scaffold.

中图分类号: