中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (49): 9291-9294.doi: 10.3969/j.issn.1673-8225.2011.49.040

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植治疗糖尿病

李  雪，陈  秋   

  1. 成都中医药大学附属医院内分泌科，四川省成都市   610075
  • 收稿日期:2011-05-20 修回日期:2011-06-21 出版日期:2011-12-03 发布日期:2011-12-03
  • 通讯作者: 陈秋，博士，硕士生导师，教授，主任，成都中医药大学附属医院内分泌科，四川省成都市 610075 chenqiu1969@yahoo.com.cn
  • 作者简介:李雪★，女，1985年生，四川省峨眉山市人，汉族，成都中医药大学在读硕士，主要从事干细胞移植及糖尿病方面的研究。 83908325@qq.com
  • 基金资助:

    四川省应用基础及卫生厅重点项目资助。

Stem cells transplantation for treatment of diabetes mellitus

Li Xue, Chen Qiu   

  1. Department of Endocrinology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu  610075, Sichuan Province, China
  • Received:2011-05-20 Revised:2011-06-21 Online:2011-12-03 Published:2011-12-03
  • Contact: Chen Qiu, Doctor, Master’s supervisor, Professor, Department of Endocrinology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China chenqiu1969@yahoo.com.cn
  • About author:Li Xue★, Studying for master’s degree, Department of Endocrinology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China 83908325@qq.com
  • Supported by:

    the Applied Basic Research Fund of Sichuan Province & Sichuan Health Bureau*

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摘要：

背景：干细胞移植可以从细胞和基因水平治疗糖尿病，从而达到临床治愈。
目的：综述近年来国内外干细胞移植治疗糖尿病的相关研究进展。
方法：应用计算机检索2000-01/2010-06 PubMed数据库、中国期刊全文数据库相关文章，检索词为“stem cells，diabetes mellitus，transplantation，insulin-secreting cell，treatment；干细胞，糖尿病，移植，胰岛素分泌细胞，治疗”，共纳入27篇文章进行综述。
结果与结论：糖尿病是一组由于胰岛素绝对或相对不足所引起的以慢性高血糖为特征的代谢性疾病，目前尚无根治的方法。干细胞具有极强的自我更新和多向分化潜能，可诱导分化为胰岛素分泌细胞，在体内和体外发挥调节血糖的作用，成为胰岛β细胞替代物的新资源。目前干细胞移植治疗糖尿病已在动物实验和小规模临床研究中取得了一定成果。

关键词: 糖尿病, 干细胞, 移植, 胰岛素分泌细胞, 治疗

Abstract:

BACKGROUND: Stem cells transplantation can treat diabetes mellitus on cell and gene levels to achieve clinical cure.
OBJECTIVE: To review the research progress addressing stem cells transplantation for diabetes mellitus.
METHODS: A computer based search was conducted in PubMed database and Chinese Journal Full-text database for relevant articles published from January 2000 to June 2010, with keywords of “stem cells, diabetes mellitus, transplantation, insulin-secreting cell, treatment” in English and Chinese, respectively. A total of 27 articles were reviewed.
RESULTS AND CONCLUSION: Diabetes mellitus is a group of metabolic disease characterized by chronic high blood sugar, which is caused by absolute or relative deficiency of insulin. Currently there is no treatment to cure it. Stem cells have a strong self-renewal and differentiation potential, which can be induced to differentiate into insulin-secreting cells to regulate blood sugar in vivo and in vitro, and they become the new resource of a substitute of islet β cells. At present, stem cells transplantation on treatment of diabetes mellitus has made some progress in animal experiments and small-scale clinical studies.

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