中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (34): 6440-6444.doi: 10.3969/j.issn.1673-8225.2011.34.042

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

注射型磷酸钙人工骨椎体后凸成形固化治疗骨质疏松性胸腰椎压缩骨折

崔  勇，孟庆刚，王  鹏，周晨亮，郜克巍，岳伟杰   

  1. 哈尔滨医科大学第四临床学院骨科，黑龙江省哈尔滨市 150001
  • 收稿日期:2011-02-09 修回日期:2011-03-09 出版日期:2011-08-20 发布日期:2011-08-20
  • 通讯作者: 岳伟杰，主任医师，哈尔滨医科大学第四临床医学院，黑龙江省哈尔滨市 150001 cuiyong88@yeah.net
  • 作者简介:崔勇☆，男，1972年生，黑龙江省哈尔滨市人，朝鲜族，1994年哈尔滨医科大学毕业，博士，主治医师，主要从事创伤骨科的诊断与治疗研究。 cuiyong88@yeah.net

Treatment of osteoporotic vertebral compression fractures with percutaneous kyphoplasty by calcium phosphate cement

Cui Yong, Meng Qing-gang, Wang Peng, Zhou Chen-liang, Gao Ke-wei, Yue Wei-jie   

  1. Department of Orthopedics, Fourth Clinical College, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
  • Received:2011-02-09 Revised:2011-03-09 Online:2011-08-20 Published:2011-08-20
  • Contact: Yue Wei-jie, Chief physician, Department of Orthopedics, Fourth Clinical College, Harbin Medical University, Harbin 150001, Heilongjiang Province, China cuiyong88@yeah.net
  • About author:Cui Yong☆, Doctor, Attending physician, Department of Orthopedics, Fourth Clinical College, Harbin Medical University, Harbin 150001, Heilongjiang Province, China cuiyong88@yeah.net

PDF

600

被引次数

18

摘要：

背景：椎体后凸成形目前常用的注射型聚甲基丙烯酸甲酯骨水泥椎体增强剂可达到增加椎体强度、稳定椎体、止痛的目的，但其组织相容性差，无生物降解性，容易造成使临近椎间盘或椎体发生变性、甚至骨折。
目的：观察注射型磷酸钙人工骨椎体后凸成形固化治疗骨质疏松性椎体压缩骨折的效果。
方法：选择2007-12/2010-06哈尔滨医科大学附属第四医院骨外科收治的骨质疏松性胸腰椎压缩性骨折患者20例，均采用经双侧椎弓根球囊扩张注射型磷酸钙人工骨行椎体后凸成形固化治疗。手术前后行疼痛目测类比评分，胸(腰)椎正侧位X射线片及椎体前缘高度、Cobb角检测。
结果与结论：术后病椎前缘椎体平均高度较术前平均高度恢复(3.38±1.44) mm (P < 0.05)。术后Cobb角较术前平均恢复(7.63±2.52)° (P < 0.05)，后凸矫正率为(38.90±11.28)%。术后3d及3周目测类比评分均较术前明显降低(P < 0.01)。说明经双侧椎弓根球囊扩张注射型磷酸钙人工骨行椎体后凸成形可以有效增加椎体强度、稳定椎体、明显缓解患者疼痛，是治疗骨质疏松性胸腰椎压缩骨折的有效方法。

关键词: 骨质疏松性椎体压缩骨折, 经皮椎体后凸成形, 磷酸钙, 人工骨, 骨水泥

Abstract:

BACKGROUND: Injectable polymethylmethacrylate (PMMA) with percutaneous kyphoplasty can increase vertebral strength, stabilize vertebral body, relieve pain, but its histocompatibility is poor with no biodegradability, which is easy to cause adjacent or vertebral body denaturation, even fractures.
OBJECTIVE: To observe the clinical effect of percutaneous kyphoplasty by calcium phosphate cement on osteoporotic vertebral compression fractures.
METHODS: Twenty cases of osteoporotic vertebral compression fractures were selected from the Fourth Affiliated Hospital of Harbin Medical University from 2007-12 to 2010-06. All cases were treated with injected calcium phosphate cement with percutaneoue kyphoplasty by bilateral transpedicular balloon approach. Preoperative and postoperative visual analog scale (VAS) score, X-ray, Cobb’s angle, variation of vertebral body height were measured.
RESULTS AND CONCLUSION: Average recovery height of the vertebral body was (3.38±1.44) mm (P < 0.05). The Cobb’s angle average recovery was (7.63± 2.52)° (P < 0.05). The restorations of kyphosis was (38.9±11.28)%. Preoperative VAS score was higher than that postoperative 3 days and 3 weeks (P < 0.01). Percutaneous kyphoplasty with injected calcium phosphate cement can effectively relieve the pain and treat osteoporotic vertebral compression fractures.

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