中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (11): 2043-2047.doi: 10.3969/j.issn.1673-8225.2010.11.036

• 组织构建综述 tissue construction review • 上一篇    下一篇

胎盘源性生长因子在缺血性脑血管病血管再生中的作用

武  磊，罗  勇   

  1. 重庆医科大学附属第一医院神经内科，重庆市神经病学重点实验室，重庆市  400016
  • 出版日期:2010-03-12 发布日期:2010-03-12
  • 通讯作者: 罗 勇，博士，研究员，博士生导师，重庆医科大学附属第一医院神经内科，重庆市 400016 luoyong1998@163.com
  • 作者简介:武 磊，男，1982年生，山西省万荣县人，汉族，重庆医科大学在读硕士，主要从事缺血性脑血管病研究。 wulei_19821982@163.com
  • 基金资助:

    课题受重庆市卫生局中医药科研项目资助(渝中医2005-B-24)。

Role of placenta-derived growth factor in vascular regeneration of ischemic cerebrovascular diseases

Wu Lei, Luo Yong   

  1. Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing Key Laboratory of Neurology, Chongqing   400016, China
  • Online:2010-03-12 Published:2010-03-12
  • Contact: Luo Yong, Doctor, Investigator, Doctoral supervisor, Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing Key Laboratory of Neurology, Chongqing 400016, China luoyong1998@163.com
  • About author:Wu Lei, Studying for master’s degree, Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing Key Laboratory of Neurology, Chongqing 400016, China wulei_19821982@163.com
  • Supported by:

    the Scientific Research Program of Traditional Chinese Medicine of Chongqing Health Bureau, No.2005-B-24*

PDF

449

被引次数

16

摘要：

背景：关于胎盘源性生长因子在促血管生长方面的作用还没完全被理解。在胎盘源性生长因子缺陷的模型研究中，胎盘源性生长因子被认为在诱导血管新生中起到关键性的作用。
目的：总结胎盘源性生长因子及其受体在血管再生和缺血性脑血管病中的作用的研究进展。
方法：计算机检索Pubmed和中国知网1990/2009相关文献。中文关键词为“胎盘源性生长因子”；英文关键词为“PLGF，angiogensis”。纳入胎盘源性生长因子的生物特性和在血管再生中的作用相关文献，以及脑缺血后血管再生和脑缺血后胎盘源性生长因子表达的相关文献。排除重复性研究。
结果与结论：文章从胎盘源性生长因子及其受体一般生物学特性，其在血管再生中的作用，胎盘源性生长因子及受体促进血管生成的机制，以及血管内皮生长因子A、胎盘源性生长因子及其受体在脑缺血后的表达和意义等方面进行了叙述。胎盘源性生长因子具有促进病理性血管新生、动脉生成及侧支生成、造血祖细胞动员的功能。胎盘源性生长因子及受体在脑缺血血管再生中有重要的作用，其治疗缺血性脑血管病可能具有很好的临床应用前景。其具体作用和机制还需进一步的研究。

关键词: 胎盘源性生长因子, 血管内皮生长因子A, 脑缺血, 血管再生, 综述文献

Abstract:

BACKGROUND: The effect of placenta-derived growth factor (PLGF) on promoting vascular regeneration remains uncertain. In studies of models with PLGF deletion, PLGF has been considered to play critical role in inducing angiogenesis.
OBJECTIVE: To summarize the research advances in effect of PLGF and its receptor in vascular regeneration and ischemic cerebral disease.
METHODS: A computer-based online search of Pubmed and CNKI was performed for relevant articles published between 1990 and 2009 with key words of “PLGF” in Chinese and “PLGF, angiogensis” Articles related with biological characteristics of PLGF and its roles in vascular regeneration and articles related with angiogenesis and PLGF expression after cerebral ischemia were selected. Repetitive articles were excluded.
RESULTS AND CONCLUSION: The role of PLGF and its receptor in vascular regeneration, mechanism of PLGF and its receptor to promote angiogenesis, vascular endothelial growth factor A, and the expression of PLGF and its receptor in brain after cerebral ischemia were introduced. PLGF can promote pathological angiogenesis, arteriogenesis, branch formation and hemopoietic progenitor cell mobilization. PLGF and its receptor play an important role in the angiogenesis of ischemic cerebral disease and display a good clinical prospect in the treatment of ischemic cerebral disease. However, the specific role and mechanism require further study.

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