细胞外基质免疫调节及在组织再生中的作用

doi:10.3969/j.issn.2095-4344.2873

中国组织工程研究 ›› 2020, Vol. 24 ›› Issue (35): 5701-5707.doi: 10.3969/j.issn.2095-4344.2873

• 组织构建综述 tissue construction review • 上一篇下一篇

细胞外基质免疫调节及在组织再生中的作用

杨文箫，杨宁，刘尧

中国医科大学口腔医学院儿童口腔医学教研室，辽宁省口腔疾病重点实验室，辽宁省沈阳市 110002

收稿日期:2020-03-09 修回日期:2020-03-14 接受日期:2020-04-15 出版日期:2020-12-18 发布日期:2020-10-19
通讯作者: 刘尧，博士，副教授，中国医科大学口腔医学院儿童口腔医学教研室，辽宁省口腔疾病重点实验室，辽宁省沈阳市 110002
作者简介:杨文箫，女，1997年生，辽宁省大连市人，汉族，中国医科大学在读硕士，主要从事口腔组织再生研究。
基金资助:
国家自然科学基金(81600825)；沈阳市“高层次创新人才计划”项目(RC190480)

Immunomodulation of extracellular matrix and its role in tissue regeneration

Yang Wenxiao, Yang Ning, Liu Yao

Department of Children’s Stomatology, School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, Liaoning Province, China

Received:2020-03-09 Revised:2020-03-14 Accepted:2020-04-15 Online:2020-12-18 Published:2020-10-19
Contact: Liu Yao, MD, Associate professor, Department of Children's Stomatology, School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, Liaoning Province, China
About author:Yang Wenxiao, Master candidate, Department of Children's Stomatology, School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, Liaoning Province, China
Supported by:
the National Natural Science Foundation of China, No. 81600825; Shenyang High-Level Innovative Talent Project, No. RC190480

摘要/Abstract

摘要：

文题释义：

免疫调节：是指生物有机体依靠自身免疫系统中的免疫分子、免疫细胞、免疫组织和免疫器官，通过与机体其他功能系统，如神经系统、内分泌系统等相互调节、相互影响，识别并清除抗原性异物，维持自身生理动态平衡与相对稳定的生理功能。

免疫应答：是指机体免疫系统对抗原刺激所产生的以排除抗原为目的的生理过程。这个过程是免疫系统各部分生理功能的综合体现，包括了抗原递呈、淋巴细胞活化、免疫分子形成及免疫效应发生等一系列的生理反应。

背景：在生物有机体中，细胞外基质和机体免疫系统之间存在相互调控作用。免疫细胞参与调控细胞外基质的不断重塑过程，细胞外基质中的蛋白及细胞因子等影响免疫细胞黏附、迁移、增殖和分化等功能。

目的：从细胞外基质发出免疫调节信号、参与免疫应答、富含免疫活性因子等方面对细胞外基质的免疫调节作用与机制作以综述。

方法：作者以“细胞外基质，免疫调节，免疫微环境，组织再生，extracellular matrix，immune regulation，immune microenvironment，tissue regeneration”等为关键词对中国知网、PubMed数据库进行检索，检索2002年至2019年的相关文献，排除与文章研究目的和研究内容无关、质量较低及重复性文章，选取60篇文章进行综述。

结果与结论：细胞外基质不仅可以为组织细胞正常的生理活动提供结构支撑，其丰富的蛋白成分及免疫活性分子在机体应对外界刺激时，还发挥着不可或缺的免疫调节作用，在机体稳态和病理状态下细胞外基质均可参与机体免疫反应，同时也为组织再生提供适宜的微环境，在组织的修复和再生中发挥作用。对于重建受损或缺失的组织器官，临床上主要采用同种异体的组织或器官移植，但常因供体短缺、移植排斥等问题，不能达到很好的疗效。组织工程技术为重建受损的组织器官提供了新的方向。然而细胞外基质在组织再生中的作用机制、最优化的应用方式、细胞外基质生物支架的标准化制备及产业化等方面仍有诸多问题有待深入研究。

ORCID: 0000-0002-0155-0499(杨文箫)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: ">免疫细胞, 细胞外基质, 免疫, 免疫调节, 免疫微环境, 细胞因子, 细胞外基质蛋白, 组织再生

Abstract:

BACKGROUND: In biological organisms, there is a mutual regulation between the extracellular matrix and immune system. Immune cells are involved in the continuous remodeling of the extracellular matrix. Proteins and cytokines in the extracellular matrix influence the adhesion, migration, proliferation and differentiation of immune cells.

OBJECTIVE: To review the immunomodulatory effect and mechanism of the extracellular matrix that sends immunomodulatory signals, participates in immune response and is rich in immunoreactive factors.

METHODS: The authors searched the articles published from 2002-2019 in PubMed and CNKI with the keywords of “extracellular matrix, immune regulation, immune microenvironment; tissue regeneration” in English and Chinese, respectively. Articles irrelevant to the purpose of the present article, and articles of low quality and repeatability were excluded, and 60 articles were finally selected for review.

RESULTS AND CONCLUSION: The extracellular matrix can not only provide structural support for tissue cells in normal physiological activities, and its rich protein components and immunoreactive molecules also play an indispensable role in immune regulation when the body responds to external stimuli. The extracellular matrix can participate in the immune response in both steady-state and pathological state, provide a suitable microenvironment for tissue regeneration and play a role in tissue repair and regeneration. Allogeneic tissue or organ transplantation is mainly used in the clinical reconstruction of damaged or defected tissues and organs, but usually cannot achieve good results due to shortage of donors and transplant rejection. Tissue engineering technology provides a new direction for the reconstruction of damaged tissues and organs. However, there are still many problems to be further studied, including the mechanism of extracellular matrix in tissue regeneration, optimized application method, standardized preparation and industrialization of extracellular matrix bioscaffolds.

Key words: immune cells, extracellular matrix, immune, immunomodulation, immune microenvironment, cytokine, extracellular matrix protein, tissue regeneration

中图分类号:

杨文箫, 杨宁, 刘尧. 细胞外基质免疫调节及在组织再生中的作用[J]. 中国组织工程研究, 2020, 24(35): 5701-5707.

Yang Wenxiao, Yang Ning, Liu Yao. Immunomodulation of extracellular matrix and its role in tissue regeneration[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(35): 5701-5707.

图/表（结果） 2

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细胞外基质免疫调节及在组织再生中的作用

Immunomodulation of extracellular matrix and its role in tissue regeneration

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