中国组织工程研究

中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (19): 3573-3580.doi: 10.3969/j.issn.2095-4344.2013.19.024

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞治疗神经退行性疾病的前景与问题干细胞治疗神经退行性疾病的前景与问题

熊 杰1，宁丽娜1，王再领1，石学敏◇2   

  1. 1武警后勤学院附属医院中医康复理疗科，天津市 300162
    2天津中医药大学第一附属医院，天津市  300192
  • 收稿日期:2012-12-01 修回日期:2013-03-27 出版日期:2013-05-07 发布日期:2013-05-07
  • 通讯作者: 石学敏，教授，主任医师，中国工程院院士，博士生导师，天津中医药大学第一附属医院，天津市 300192 tjdrshi@msn.com
  • 作者简介:熊杰☆，女，1967年生，天津市人，汉族，1990年天津中医学院毕业，博士，教授，主任医师，硕士生导师，主要从事神经系统疾病的临床与实验研究。 drxiongjie@yahoo.com.cn

Prospects and problems of stem cells in the treatment of neurodegenerative diseases

Xiong Jie1, Ning Li-na1, Wang Zai-ling1, Shi Xue-min2   

  1. 1 Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy, Affiliated Hospital of Armed Police Logistics Institute, Tianjin  300162, China
    2 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin  300192, China
  • Received:2012-12-01 Revised:2013-03-27 Online:2013-05-07 Published:2013-05-07
  • Contact: Xiong Jie☆, M.D., Professor, Chief physician, Master’s supervisor, Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy, Affiliated Hospital of Armed Police Logistics Institute, Tianjin 300162, China drxiongjie@yahoo.com.cn
  • About author:Xiong Jie☆, M.D., Professor, Chief physician, Master’s supervisor, Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy, Affiliated Hospital of Armed Police Logistics Institute, Tianjin 300162, China drxiongjie@yahoo.com.cn

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摘要：

背景：虽然各种神经退行性疾病的人群发病率居高不下且有上升趋势，但至今仍无有效治疗方法，因此，寻求有效的治疗神经退行性疾病的途径是科学界面临的挑战。
目的：文章分析和综述了对干细胞治疗神经退行性疾病的近年研究进展及热点问题。
方法：文章对干细胞移植治疗神经退行性疾病，如阿尔茨海默病、帕金森病、脑卒中、亨廷顿病、视网膜色素变性疾病、肌萎缩性侧索硬化症、癫痫等疾病的基础与临床研究进展进行概述，探讨干细胞治疗神经退行性疾病的可行性、优势及问题。
结果与结论：干细胞治疗神经退行性疾病大部分研究还是集中在实验动物模型阶段，还没有支持干细胞临床治疗的有效证据，其安全性和有效性还没有确切临床保证和标准，临床治疗效果及不良反应都有待大宗及长期临床试验研究进一步验证。

关键词: 干细胞, 干细胞学术探讨, 干细胞移植, 神经干细胞, 中枢神经系统, 神经退行性疾病, 阿尔茨海默病, 帕金森病, 脑卒中, 亨廷顿病, 视网膜变性疾病, 肌萎缩性侧索硬化症, 癫痫, 临床研究

Abstract:

BACKGROUND: Although the incidence of neurodegenerative diseases in various populations is high and has an upward trend, so far there is no effective treatment method. So it is a challenge for scientific community to seek effective treatment method for the treatment of neurodegenerative diseases.
OBJECTIVE: To analyze and review the research progress and hot issues of stem cells for the treatment of neurodegenerative diseases.
METHODS: The basic and clinical researches on stem cells for the treatment of neurodegenerative diseases were overviewed, including Alzheimer’s disease, Parkinson’s disease, stroke, Huntington’s disease, retinitis pigmentosa, amyotrophic lateral sclerosis and epilepsy, in order to investigate the feasibility, advantages and problems of stem cells in the treatment of neurodegenerative diseases.
RESULTS AND CONCLUSION: Most of the studies on stem cells in the treatment of neurodegenerative diseases are in the stage of experimental animal models, and there is no valid evidence to support stem cell therapy. There is no exact clinical assurance and standards on the safety and efficacy of stem cells for the treatment of neurodegenerative diseases, and the clinical efficacy and adverse reactions need to be further verified with large-sample long-term clinical trials.

Key words: stem cells, stem cell academic discussion, stem cell transplantation, neural stem cells, central nervous system, neurodegenerative diseases, Alzheimer’s disease, Parkinson’s disease, stroke, Huntington’s disease, retinal degenerative diseases, amyotrophic lateral sclerosis, epilepsy, clinical study

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